1. Your Presenter: Luana DeAngelisYour Presenter: Luana DeAngelis
Director, Founder,
Patient Navigator:
• 2x Breast cancer survivor
• Generational background in
Natural Health
• Founder/Executive Director:
You Can Thrive! Foundation
• Often called as an expert by large
media outlets
• Passionate about holistic methods

2. Disclosure:
I will discuss investigational use in my presentation.
I have no conflicts of interest to disclose:
For full disclosure You Can Thrive! receives a product grant
from Young Living Oils since 2008. I am also an
independent distributor of essential oils.
Founder/Director of: You Can Thrive!
The Benefits and Considerations
of Using Therapeutic
Essential Oils in Cancer Care

3. Disclosure:
Statements made on this presentation are generally pertaining to
Young Living Essential Oils. Statements and data have not been
evaluated by the FDA. These products and information are not
intended to diagnose, treat, cure or prevent any disease. Anyone
suffering from disease or injury should consult with a physician. If
you are currently on medication, please DO NOT STOP.
These compounds are meant to support your health only.
The Benefits and Considerations
of Using Therapeutic
Essential Oils in Cancer Care

4. Summary
This presentation will provide an overview of therapeutic grade
essential oils and their efficacy to both detoxify and promote health in
the body as a whole.
• History
• How oils are produced
• What makes oils effective
• Basic science
• Promising data
• Additional uses for the oils
• Q&A at the end of the presentation.

5. • WWII: Dr. Jean Valet used essentials oils to
treat soldiers
• 1950’s: Marguerite Maury was first to give
prescribed combinations
• Late 70’s early 80’s: essentials oils became
major part of alternative holistic health
systems
“Aromatherapy” first coined in 1937 by the French chemist and
perfumer Rene Maurice Gattefosse.
Modern Medicine
Aromatherapy

6. • “Life Blood” of the plants they were
harvested from.
• Principally composed of classic organic
compounds
• Extremely Concentrated: one drop
contains 40 million-trillion molecules.
What Are Essential Oils?What Are Essential Oils?

7. Why are Essential OilsWhy are Essential Oils
So Effective?So Effective?
Ripple Effect: Takes one molecule to open
the right receptor and communicate with the
DNA to alter cellular function.
Our bodies know exactly what to do with
these oils; the body uses what it needs and
rejects the rest.

8. Limbic System Delivery

9. • Terpenes: make essential oils unique
• More active compounds within essential oils
contain more isoprene unites
• Main organic compound categories:
(each group exerts specific actions on human cells)
• Phenylpropanoids
• Monoterpenes
• Sesquiterpenes
• Antineoplastic
Organic ConstituentsOrganic Constituents

10. Therapeutic GradeTherapeutic Grade
• Optimal naturally occurring blend of constituents
to maximize desired effect.
• Shelf Life:
• Therapeutic Grade= Forever (with exceptions)
• Impure Oils= 2 year
• Can turn rancid
• Tiny percentage of oils in the world are meant for
medicine.

11. •Therapeutic Grade:
•Careful monitoring process and seed
selection.
•Grown in areas with low concentrations of
pollution
•Crops managed by hand and no pesticides or
fertilizers
ProductionProduction

13. Other Terms
•Blocking Agent: prevent carcinogens from reaching target
sites by acting as barriers
•Suppressing Agents: Suppress proteins expressed by
cancer cells that signal uncontrolled growth
Cancer | Pathways
One means of classifying inhibitors is on the basis of the time in
the carcinogenic process at which they exert their inhibitory
effects. Some PREVENT the formation of carcinogens.

14. Cancer | Cellular Stress
Masayasu Jo – Taichiro Nishikawa –
Yoshihisa Okada – Kanji Yamaguchi –
Hironori Mitsuyoshi – Kohichiroh
Yasui – Masahito Minami – Masaki
Iwai – Keizo Kagawa – Yoshito Itoh –
Toshikazu Yoshikawa
Oxidative stress is closely associated with tumor
Angiogenesis of hepatocellular (Liver) carcinoma
ORIGINAL ARTICLE – LIVER, PANCREAS AND
BILIARY TRACT
Received 22 December 2009/ Accepted 9 February
2011/ Published Online 31 March 2011

15. ORAC Designation

16. Prevention: the cure?
Normal course of
cancer progression
Cancer prevention

17. .“Monoterpenes in breast cancer chemoprevention”
The multiple antitumorgenic effects of limonene are attainable
at a high therapeutic ratio, suggesting that limonene and related
monoterpenes may be efficacious in the chemoprevention and
chemotherapy of human malignancies”.
Complete Tumor Regression –The complete regression of
mammary carcinomas by limonene appears to involve tissue
redifferentiation.
Breast Cancer Res Treat 1997 Nov-Dec;46(2-3):191-7 Crowell PL.
Abstract - Pub Med – National Library of Medicine / National Institutes of Health
D-Limonene (Citrus Peel Oil)D-Limonene (Citrus Peel Oil)

18. TRdonePhase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign
Phase I/II Clinical Trials Committee.
D M Vigushin, G K Poon, A Boddy, J English, G W Halbert, C Pagonis, M Jarman, R C Coombes
Department of Medical Oncology, Charing Cross Hospital, London, UK.
PURPOSE: D-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in
preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics
in patients with advanced cancer was followed by a limited phase II evaluation in breast cancer.
D-Limonene + Cancer StudiesD-Limonene + Cancer Studies
One partial response in a breast cancer patient on 8
g/m2 per day was maintained for 11 months; three
patients with colorectal carcinoma had prolonged stable
disease. There were no responses in the phase II study..
CONCLUSIONS: D-Limonene is well tolerated in
cancer patients at doses which may have clinical
activity. The favorable toxicity profile supports further
clinical evaluation.

19. Since the reactive ultimate carcinogenic forms of
chemical carcinogens are electrophiles, induction
of GST activity by anticarcinogenic compounds is
believed to be a major mechanism for carcinogen
detoxification”.
“Glutathione S-transferase (GST) catalyzes the reaction of glutathione with electrophiles
to form less toxic conjugates for excretion”
It appears that one way that essential oils
work is through more effective detoxification.
Limonene ConsiderationsLimonene Considerations

20. Clove| The most powerful antioxidant oil~ ORAC value of: 1,078,700 uTE/110G
Eugenol is an essential oil mainly found in the buds and
leaves of clove (Syzygium aromaticum (L.)
Eugenol inhibits cell proliferation and
induces apoptosis in human MCF-7 breast
cancer cells (in vitro).
The biological activities of Eugenol in
human breast cancer cells can be
correlated to its potential activity as an
estrogen receptor (ER) antagonist.

21. Results of Therapeutic Oils Studied InResults of Therapeutic Oils Studied In
Human Cancer Cell LinesHuman Cancer Cell Lines
60 Oils Tested for their anti-cancer activity. Results for oils that inhibit
cancer growth in-vitro with low normal cell toxicity
BREAST CANCER
Concentration (parts
per million)
% Cell
Inhibition
Sandalwood 100 ppm 98.10
Myrtle 200 ppm 95.20
Tsuga 200 ppm 93.10

22. Symptom Relief
• Neuropathy – Frankincense/Peppermint/ reflexology
• Hot Flashes – Peppermint on back on neck
• Fatigue – Peppermint – inhaled and on temples
• Pain- Peppermint topically
• Chemobrain- Peppermint
• Depression - Orange
• Anxiety an array of oils almost any oil will help anxiety
• Nausea- Ginger, peppermint, Fennel inhaled and/or on tongue
• Insomnia- valerian, lavender
• Courage- Frankincense, Tansy, Rosewood,

23. Internal & Experimental Use
• Certain oils can be used internally as part of a
regimen for maintaining health
• Quality is imperative
• Consult with a professional
EXPERIMENTAL USE:
• In some places in the world essential oils are being
diluted and used intravenously

24. Therapeutic Grade
Can Promote health:
•Fatigue
•Pain
•Cellular Oxidation
•Hot flashes
•Lymphadema
•Hormone Imbalance
•Anxiety
•Nausea
• Non-toxic
• Safe in clinical settings
• Safe for internal use

26. Peppermint Oil
Peppermint oil like the ‘Swiss army
knife” of oils and can be used with a
multitude of symptoms to promote health
amidst the side effects that accompany
many conventional treatment protocols.

27. EmotionalEmotional BenefitsBenefits
Lessen Anxiety
Reduce Stress
Diminish Fear
Ease Depression
Increase Feelings of Hope
Enhance Sense of Empowerment
Lavender, Valerian, Chamomile
Lavender, so many others
Valerian, Tansy, Frankincense
Jasmine, Frankincense
Sandalwood
Pepper, Sage, Nutmeg

28. Reduce Fatigue
Mitigate Nausea
Alleviate Pain
Improve Sleep
Moderate Symptoms of
Neuropathy
Enhance Mental Clarity
Physical BenefitsPhysical Benefits
Juniper, Cypress, Thyme
Peppermint
Peppermint, Wintergreen
Valerian, Lavender
Peppermint, Frankincense
Geranium, Cypress
Peppermint, Rosemary,
Lemon

29. Traditional Uses include:
•Rubbing on forehead, temples, and/or back of neck
traditionally used for headaches and hot flashes
•Inhaled & Internally nausea, dizziness or simple halitosis
•Apply topically to alleviate pain
•Diffuse, inhale to improve concentration
•Apply over stomach or ingest to promote healthy digestion
•Rub on bottoms of feet and armpits/groin to soothe fever
Folk Uses for PeppermintFolk Uses for Peppermint

30. New species of frankincense dubbed “sacra” have been found to
have a different and more potent form of Boswellic acid compounds.
.
FrankincenseFrankincense

31. FrankincenseFrankincense
can provide cancer-specific cell death

32. Activates genes responsible for suppressed cancer cell
growth and elevated cancer cell death
Frankincense & OncogenesFrankincense & Oncogenes
Gene Symbol
Time after frankincense oil exposure(hours)
0 <0.5 0.5-1 1-2 2-3
IL8 26.3 32.6 146.2 693.6 1241.4
CLK1 42.3 56.1 57.9 121.2 203.3
DLG1 48.3 41.2 31.2 71.8 37.2
H2AFX 105.6 103.3 106.6 51.0 96.1
ING4 73.7 63.0 75.3 37.2 43.6
KLF4 89.2 68.8 123.2 326.0 556.9
NEDD9 38.3 34.3 23.8 59.7 56.7
SSTR1 47.4 37.2 28.4 70.3 27.2
CDKN1A 56.3 54.5 95.7 167.4 382.9
DDIT3 346.7 316.0 523.2 735.5 1647.7
HDAC4 64.4 61.7 52.1 68.0 31.5
IL1A 63.4 44.5 72.1 124.5 252.5
IL6 190.5 235.4 337.2 563.8 1326.4
SNF1LK 40.6 38.8 48.9 95.8 286.3
IL8 26.3 32.6 146.2 693.6 1241.4
CLK1 42.3 56.1 57.9 121.2 203.3
DLG1 48.3 41.2 31.2 71.8 37.2
Growthinhibitorygenes
Cell death genes

33. FrankincenseFrankincense && Pancreatic CancerPancreatic Cancer
Purpose
“Frankincense essential oil prepared from
hydrodistillation of Boswellia sacra gum resins
induces human pancreatic cancer cell death in
cultures and in a xenograft murine model.
Conclusion
“All fractions of Frankincense essential oil from Boswellia sacra are
capable of suppressing viability and inducing apoptosis of a panel of
human pancreatic cancer cell lines.”
BMC Complement Altern Med. 2012 Dec 13;12:253. doi: 10.1186/1472-6882-12-253.
Ni X1, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK.
Author information1Department of General Surgery, Long Hua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.

34. Library/ID
Area (%)
78 o
C 0-2 hr 78 o
C 9-10 hr 78 o
C 0-12 hr 100 o
C 12 hr
trans-beta-caryophyllene 0.02 0.02 0.28 0.62
alpha-humulene 0.03 0.01 0.11 0.17
allo-aromadendrene 0.02 0.06
gamma-muurolene 0.01 0.05 0.10
germacrene D 0.02 0.09
beta-selinene 0.01 0.02 0.21 0.45
alpha-selinene 0.02 0.01 0.12 0.24
gamma-cadinene 0.04 0.07
delta-cadinene 0.01 0.05 0.14
caryophyllene oxide 0.02 0.05
trans-beta-caryophyllene 0.02 0.02 0.28 0.62
Temperature DistillationTemperature Distillation
Chemical components depend on duration and temperature of distillationChemical components depend on duration and temperature of distillation

35. Frankincense & Breast CancerFrankincense & Breast Cancer
Purpose
“Boswellia sacra essential oil induces tumor cell-specific apoptosis
and suppresses tumor aggressiveness in cultured human breast
cancer cells”
Conclusion
“Boswellia sacra essential oil represses signaling pathways and cell
cycle regulators that have been proposed as therapeutic targets for
breast cancer”
BMC Complement Altern Med. 2011 Dec 15;11:129. doi: 10.1186/1472-6882-11-129.
Suhail MM1, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin
HK.
Author information
1Al Afia Medical Complex, Salalah, Sultanate of Oman.

36. • Essential oils are a beneficial, if not critical
component of any holistic approach to caring
for, or staying healthy in the face of serious
illness.
• Essential oils can be beneficial both physically
and emotionally to enhance mental capacity to
deal with stress and illness.
• More research is needed in human subjects to
determine their use as treatment or adjunct
prevention methods for cancer.
Conclusion

37. Thrive!
Now get out there and

38. Questions?
Disclosure:
Statements made on this presentation are generally pertaining to Young
Living Essential Oils. Statements and data have not been evaluated by the
FDA. These products and information are not intended to diagnose, treat,
cure or prevent any disease. Anyone suffering from disease or injury should
consult with a physician. If you are currently on medication, please DO NOT
STOP.
These compounds are meant to support your health only