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Clinical Case
Study
BRIANNA MCKENNA
PROFESSOR LASHAWN MCKOY
MLT 2015
DECEMBER 16, 2019
Patient Introduction
Patient Introduction
▪ 45 year old female
▪ Admitted for liver failure
▪ Length of stay: 2 weeks
Phlebotomy
Phlebotomy
▪ Gold top-contains gel and clot activators, used for chemistry tests
▪ Purple top-contains EDTA, used for hematology
▪ Light blue top-contains sodium citrate, used for coagulation tests
▪ Urine cup-used for urinalysis and urine culture
Patient Results
Hematology
CBC WITH WBC DIFFERENTIAL
Complete Blood Count Results
Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4
WBC 10.6 x103/mcL 10.3 x103/mcL 12.2 x103/mcL *H 17.1 x103/mcL *H
RBC 2.28 x106/mcL *L 1.93 x106/mcL *L 2.37 x106/mcL *L 2.58 x106/mcL *L
Hgb 7.7 gm/dL *L 6.5 gm/dL *LC 7.8 gm/dL *L 8.5 gm/dL *L
Hct 22.8% *L 19.5% *L 23% *L 25% *L
MCV 100 fL 101 fL 97 fL 96.9 fL
MCH 33.8 pg *H 33.7 pg *H 32.9 pg *H 32.9 pg *H
MCHC 33.8 gm/dL 33.3 gm/dL 33.9 gm/dL 34 gm/dL
RDW Value not given 28% *H 26.7% *H 26.8% *H
Platelets 95 x103
/mcL *L 88 x103
/mcL *L 89 x103
/mcL *L 70 x103
/mcL *L
Neutrophils 8.5 x103
/mcL *H 7.8 x103
/mcL 9.4 x103
/mcL *H 13.7 x103
/mcL *H
Lymphocytes 0.4 x103
/mcL 0.5 x103
/mcL 0.6 x103
/mcL 0.7 x103
/mcL
Monocytes 1.2 x103/mcL 1.2 x103/mcL 1.5 x103/mcL *H 1.3 x103/mcL
Eosinophils 0 x103
/mcL 0 x103
/mcL 0 x103
/mcL 0 x103
/mcL
Basophils 0 x103
/mcL 0 x103
/mcL 0 x103
/mcL 0.1 x103
/mcL
Implications
▪ Anisocytosis-high RDW
▪ May be false due to WBC
▪ May be due to past transfusion
▪ Low H&H
▪ Anemia
▪ Increased Neutrophils
▪ Possible infection
▪ Decreased platelets
▪ Decreased clotting ability
Chemistry
CMP
Complete Metabolic Panel
Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4
Glucose 179 H 377 H 187 H 110 H
BUN 23 H 25 H 26 H 31 H
Creatinine 1.89 H 1.81 H 1.81 H 1.48 H
Na 132 L 131 L 129 L 132 L
K 2.8 L 2.4 LC 3 L 2.5 LC
Cl 96 L 93 L 93 L 98
CO2 18 L 24 21 20 L
Ca 6 L 5.4 LC 5.3 LC 5.5 LC
Total Bili 27 H 24.7 H 28.3 H 26.6 H
Direct Bili Not Included Not Included Not Included Not Included
Total Protein 6.2 L 5.6 L 6.5 5.6 L
Albumin 2.3 L 2.1 L 2.3 L 2 L
ALP 61 45 57 57
AST 135 H 114 H 127 H 115 H
ALT 75 H 70 H 81 H 82 H
Implications
▪ Low sodium, potassium, chloride, CO2
▪ Acid/base balance issues
▪ Increased bilirubin
▪ Liver damage
▪ Increase glucose
▪ Possible diabetes
▪ Increased BUN and creatinine
▪ Kidney damage
Coagulation
PT AND PTT
Coagulation Results
Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4
PT 18.7 H 18.4 H 16.6 H 18.9 H
PTT 46.7 H 45 H 40.8 H 45.1 H
Implications
▪ Increased PT and PTT
▪ Decreased clotting ability
▪ Matches decreased platelets
Urinalysis
Urinalysis
Analyte
Color
Clarity
SpecificGravity
Glucose
Bilirubin
Ketones
Blood
pH
Protein
Urobilinogen
Nitrite
LeukocyteEsterase
WBC
RBC
SquamousCells
RTEs
TransitionalCells
Casts
Yeast
Bacteria
Mucus
Crystals
Specimen1
Amber
Turbid
1.02
100
large
15
Small
6.5
>300
2.0
positive
moderate
51-75
6-10
few
moderate
none
3-5granular
none
many
none
none
Implications
▪ Moderate RTEs
▪ Kidney damage
▪ Bilirubin
▪ Liver damage
▪ Most positive results
▪ Urinary Tract Infection
Microbiology
URINE CULTURE
Results and Implications
▪ E. coli identified in urine
▪ Very common
▪ Susceptibility done
▪ Ampicillin resistance
▪ Otherwise very sensitive
Treatment
Medication List
▪ Acyclovir- Antiviral, treats viral infections
▪ Cefepime- Antibiotic, treats bacterial infections
▪ Calcium/Vitamin D- Supplement
▪ Ciprofloxacin- Antibiotic, treats bacterial infections
▪ Famotidine- Antacid, reduces stomach acid
▪ Folic Acid- supplement
▪ Glucose- nutrient
▪ Rifaximin- Antibiotic, treats diarrhea and certain liver problems
▪ Thiamine- supplement
▪ Albuterol- bronchodilator, treats/prevents bronchospasm
Diagnosis & Prognosis
Diagnosis
▪ Liver Failure
▪ Supported by increased bilirubin, increased AST & ALT
▪ Severe damage leading to organ shutdown
▪ Kidney Damage
▪ Increased BUN & creatinine, abnormal acid/base balance
▪ Anemia
▪ Low RBCs, Hgb, Hct
▪ Urinary Tract Infection
▪ Increased WBCs in urine & blood, positive E. coli in culture
Prognosis
▪ Liver failure: life threatening
▪ Depending on cause, may be reversible
▪ Often requires transplant
▪ Permanent damage can shorten life span
▪ Kidney damage: depends on severity
▪ Treatable if caught early
▪ Life threatening if progressed to kidney failure
▪ Anemia
▪ Generally good prognosis
▪ Usually treated with supplements, transfusion is severe cases
▪ UTI: very common
▪ Easily treated
▪ No lasting effects if caught early
▪ May cause permanent kidney damage if left untreated
Works Cited
Acute liver failure. (2017, August 29). Retrieved from
https://www.mayoclinic.org/diseases-conditions/acute-liver-
failure/diagnosis-treatment/drc-20352868.
Cunha, J. P. (2018, December 12). Acute Kidney Failure Treatment,
Causes & Symptoms. Retrieved from
https://www.emedicinehealth.com/acute_kidney_failure/article_e
m.htm#acute_kidney_failure_diagnosis.
Turner, J. (2019, November 5). Anemia. Retrieved from
https://www.ncbi.nlm.nih.gov/books/NBK499994/.

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Case study fall2019

  • 1. Clinical Case Study BRIANNA MCKENNA PROFESSOR LASHAWN MCKOY MLT 2015 DECEMBER 16, 2019
  • 3. Patient Introduction ▪ 45 year old female ▪ Admitted for liver failure ▪ Length of stay: 2 weeks
  • 5. Phlebotomy ▪ Gold top-contains gel and clot activators, used for chemistry tests ▪ Purple top-contains EDTA, used for hematology ▪ Light blue top-contains sodium citrate, used for coagulation tests ▪ Urine cup-used for urinalysis and urine culture
  • 7. Hematology CBC WITH WBC DIFFERENTIAL
  • 8. Complete Blood Count Results Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4 WBC 10.6 x103/mcL 10.3 x103/mcL 12.2 x103/mcL *H 17.1 x103/mcL *H RBC 2.28 x106/mcL *L 1.93 x106/mcL *L 2.37 x106/mcL *L 2.58 x106/mcL *L Hgb 7.7 gm/dL *L 6.5 gm/dL *LC 7.8 gm/dL *L 8.5 gm/dL *L Hct 22.8% *L 19.5% *L 23% *L 25% *L MCV 100 fL 101 fL 97 fL 96.9 fL MCH 33.8 pg *H 33.7 pg *H 32.9 pg *H 32.9 pg *H MCHC 33.8 gm/dL 33.3 gm/dL 33.9 gm/dL 34 gm/dL RDW Value not given 28% *H 26.7% *H 26.8% *H Platelets 95 x103 /mcL *L 88 x103 /mcL *L 89 x103 /mcL *L 70 x103 /mcL *L Neutrophils 8.5 x103 /mcL *H 7.8 x103 /mcL 9.4 x103 /mcL *H 13.7 x103 /mcL *H Lymphocytes 0.4 x103 /mcL 0.5 x103 /mcL 0.6 x103 /mcL 0.7 x103 /mcL Monocytes 1.2 x103/mcL 1.2 x103/mcL 1.5 x103/mcL *H 1.3 x103/mcL Eosinophils 0 x103 /mcL 0 x103 /mcL 0 x103 /mcL 0 x103 /mcL Basophils 0 x103 /mcL 0 x103 /mcL 0 x103 /mcL 0.1 x103 /mcL
  • 9. Implications ▪ Anisocytosis-high RDW ▪ May be false due to WBC ▪ May be due to past transfusion ▪ Low H&H ▪ Anemia ▪ Increased Neutrophils ▪ Possible infection ▪ Decreased platelets ▪ Decreased clotting ability
  • 11. Complete Metabolic Panel Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4 Glucose 179 H 377 H 187 H 110 H BUN 23 H 25 H 26 H 31 H Creatinine 1.89 H 1.81 H 1.81 H 1.48 H Na 132 L 131 L 129 L 132 L K 2.8 L 2.4 LC 3 L 2.5 LC Cl 96 L 93 L 93 L 98 CO2 18 L 24 21 20 L Ca 6 L 5.4 LC 5.3 LC 5.5 LC Total Bili 27 H 24.7 H 28.3 H 26.6 H Direct Bili Not Included Not Included Not Included Not Included Total Protein 6.2 L 5.6 L 6.5 5.6 L Albumin 2.3 L 2.1 L 2.3 L 2 L ALP 61 45 57 57 AST 135 H 114 H 127 H 115 H ALT 75 H 70 H 81 H 82 H
  • 12. Implications ▪ Low sodium, potassium, chloride, CO2 ▪ Acid/base balance issues ▪ Increased bilirubin ▪ Liver damage ▪ Increase glucose ▪ Possible diabetes ▪ Increased BUN and creatinine ▪ Kidney damage
  • 14. Coagulation Results Analyte Specimen 1 Specimen 2 Specimen 3 Specimen 4 PT 18.7 H 18.4 H 16.6 H 18.9 H PTT 46.7 H 45 H 40.8 H 45.1 H
  • 15. Implications ▪ Increased PT and PTT ▪ Decreased clotting ability ▪ Matches decreased platelets
  • 18. Implications ▪ Moderate RTEs ▪ Kidney damage ▪ Bilirubin ▪ Liver damage ▪ Most positive results ▪ Urinary Tract Infection
  • 20. Results and Implications ▪ E. coli identified in urine ▪ Very common ▪ Susceptibility done ▪ Ampicillin resistance ▪ Otherwise very sensitive
  • 22. Medication List ▪ Acyclovir- Antiviral, treats viral infections ▪ Cefepime- Antibiotic, treats bacterial infections ▪ Calcium/Vitamin D- Supplement ▪ Ciprofloxacin- Antibiotic, treats bacterial infections ▪ Famotidine- Antacid, reduces stomach acid ▪ Folic Acid- supplement ▪ Glucose- nutrient ▪ Rifaximin- Antibiotic, treats diarrhea and certain liver problems ▪ Thiamine- supplement ▪ Albuterol- bronchodilator, treats/prevents bronchospasm
  • 24. Diagnosis ▪ Liver Failure ▪ Supported by increased bilirubin, increased AST & ALT ▪ Severe damage leading to organ shutdown ▪ Kidney Damage ▪ Increased BUN & creatinine, abnormal acid/base balance ▪ Anemia ▪ Low RBCs, Hgb, Hct ▪ Urinary Tract Infection ▪ Increased WBCs in urine & blood, positive E. coli in culture
  • 25. Prognosis ▪ Liver failure: life threatening ▪ Depending on cause, may be reversible ▪ Often requires transplant ▪ Permanent damage can shorten life span ▪ Kidney damage: depends on severity ▪ Treatable if caught early ▪ Life threatening if progressed to kidney failure ▪ Anemia ▪ Generally good prognosis ▪ Usually treated with supplements, transfusion is severe cases ▪ UTI: very common ▪ Easily treated ▪ No lasting effects if caught early ▪ May cause permanent kidney damage if left untreated
  • 26. Works Cited Acute liver failure. (2017, August 29). Retrieved from https://www.mayoclinic.org/diseases-conditions/acute-liver- failure/diagnosis-treatment/drc-20352868. Cunha, J. P. (2018, December 12). Acute Kidney Failure Treatment, Causes & Symptoms. Retrieved from https://www.emedicinehealth.com/acute_kidney_failure/article_e m.htm#acute_kidney_failure_diagnosis. Turner, J. (2019, November 5). Anemia. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK499994/.