GKA deel 2 college 10

Vaccinatie proeven (I) Science, 260, 1993, p.1259 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Science 1993

Vaccinatie proeven (II) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Science 1993

Adeno-based vaccine aimed at CTL: the STEP-trial ,[object Object],[object Object],Science, 21 Nov 2007  Science 1993

HIV survives drugs in T cells Balter, Science 278, 1997, 1227; Finzi et al., id. 1295-1300 ,[object Object],Tijd onder HAART (maanden) Plasma HIV-1 RNA (kopieën/ml 10 2 10 6 10 5 10 4 10 3 10 7 6 12 18 24 30 0 -8 -12

Herstel van CD4 na HAART Balter, Science 278, 1997, 1227; Finzi et al., id. 1295-1300 ,[object Object],[object Object]

Active HIV is present in resting T-cells . Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therap y, Finzi et al. Science 278,1997, 1295 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Is hidden HIV resistant to protease inhibitor? Finzi et al. Science 278,1997, 1295 ,[object Object],=========== Ritonavir Saquinavir Patient Protease inhibitor 10 ctcL 20 aagK 33 ttaL 36 atgM 46 atgM 48 gggG 54 atcI 71 gctA 82 gtcV 84 ataI 90 ttg L 1 RTV, SQV --- --- --- --- --- --- --- --- --- --- ---

Is hidden HIV resistant to protease inhibitor? Finzi et al. Science 278,1997, 1295 ,[object Object],=========== Answer: No! Ritonavir Saquinavir Patient Protease inhibitor 10 ctcL 20 aagK 33 ttaL 36 atgM 46 atgM 48 gggG 54 atcI 71 gctA 82 gtcV 84 ataI 90 ttg L 1 RTV, SQV --- --- --- --- --- --- --- --- --- --- ---

How HIV defeats the immune system Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object],[object Object],[object Object]

Time course of HIV-infection Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object]

How HIV meets the immune system (a) Nowak & Mc Michael, Sci Am 1995, 42-49

How HIV meets the immune system (b) Nowak & Mc Michael, Sci Am 1995, 42-49

Evolution of HIV: escape mutants Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Time course of HIV-infection Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object],[object Object],[object Object],[object Object],Set-point Diversity break-point

Model for progression rate Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object]

Immune dominance Nowak & Mc Michael, Sci Am 1995, 42-49 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],============

GKA deel 2 college 10

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Viewers also liked

Viewers also liked (7)

Similar to GKA deel 2 college 10

Similar to GKA deel 2 college 10 (20)

More from Biology, Utrecht University

More from Biology, Utrecht University (20)

GKA deel 2 college 10