ARZU DIDEM YALCIN

1. ARZU DIDEM YALCIN, MD. ( 姚晶愛)
Internal Medicine, Allergy and Clinical
Immunology
Academia Sinica, Genomics Research
Center, Taipei, Taiwan
adidyal@yahoo. com
adidyal@gate. sinica.edu. tw

2. Biomaterials Research - Manfred Maitz

3. Biomaterials Research - Manfred Maitz

4. Biomaterials Research - Manfred Maitz

5. Biomaterials D-dimer Research - Manfred Maitz

6. Biomaterials Research - Manfred Maitz
GROUP-1 SEVERE ASTMA
n:20
1A- BEFORE OMALIZUMAB
1B- AFTER 4TH MONTH OMALIZUMAB
1C-AFTER 8TH MONTH OMALIZUMAB
1D-AFTER 12TH MONTH OMALIZUMAB

7. Biomaterials Research - Manfred Maitz
 Figure 1: (Group I:SPA, n:20) D-Dimer levels (mean±SD). Group IA:
467.63±106.39. Group IB: 430.00 ± 92.90. Group IC: 401.21 ± 72.19. Group
ID: 377.37 ± 62.33. Group IA, using desloratadin, inhalan forte doses
steroid .We compared DD levels between groups: The significant DD
difference was observed between group-IA and group-IC (p<0.05),
(P=0.031); between group-IA and group-ID (p<0.05), (P=0.003); between
group-IB and group-ID (p<0.05), (P=0.049); a significant positive
correlation between age and ADY (p=0.043, r=0.468, p<0.05). In the
group-ID there was a significant positive correlation between DD and age
(p=0.034, r=0.488, p<0.05).

8. Biomaterials Research - Manfred Maitz
2A-1-BEFORE OMALIZUMAB-AKTIVE PHASE N:8
2A-2-BEFORE OMALIZUMAB- PASSIVE PHASE
2B-AFTER 4TH MONTH OMALIZUMAB
2C- AFTER 8TH MONTH OMALIZUMAB
2D- AFTER 12TH MONTH OMALIZUMAB

9. Biomaterials D-dRiesmeearrch - Manfred Maitz
 e 2: (Group II: CU, n:8) D-Dimer levels (mean±SD). Group
IIA-1: 506.25 ± 133.93. Group IIA-2 : 437.75 ± 54.83. Group
IIB: 408.00 ± 125.39. Group IIC: 377.38 ± 104.50. Group IID:
350.87 ± 70.60. Group IIA-2 consisted of patients whose
lesions were passive stage.
 Omalizumab was given to group IIB and IIC (225- 375 MG)
and gradually was ceased and continued with desloratadin
1x1. Group IID patients were under omalizumab medication
only.
 The significant DD difference was observed between
Group IIA-1 and Group-IID (p<0.05), (P=0.015). In the IIA-1
group there was a significant positive correlation
between DD and age (p=0.008, r=0.848, p<0.005).

10. Biomaterials D-dRiesmeearrch - Manfred Maitz
 Extrinsic pathway of coagulation is activated in responce to high
level of circulatory IgE. Best example of this purported
relationship is the correlation between higher TF expression and
vasculitis degree that has been seen in Hyper IgE Syndrome.
 After omalizumab therapy, significant decrease of the levels of
DD shows the importance of procoagulant state in allergic
patients. We also believe that DD may also have an important
role for the relationship between IgE and extrinsic pathway in
the endothelial cells.
 Mediators and cells classically involved in
procoagulant and anticoagulant pathways
altogether play a role in SPA and CU
pathophysiology and omalizumab effect.

11. Biomaterials Research - Manfred Maitz

12. Biomaterials Research - Manfred Maitz

13. Biomaterials YalRcesienar chA D- M.a nEfrveda Mlauitaztion of Homocysteine,
Eosinophil Cationic Peptide, 25(OH)
Vitamin D, and Immune Modulator OX-2
Levels in Moderate Allergic Asthma
Patients: Association with Biological
Treatment (Anti-IgE )& Disease Activity.
 25(OH)D triggers a Hcy metabolizing enzyme and data from the
Longitudinal Aging Study Amsterdam suggested a correlation
between vitamin D status and Hcy levels.In vitro and in vivo
studies showed that Hcy has an ability of influencing
inflammatory cytokine/chemokine production and it might be
through peripheral blood monocytes and monocyte-derived
macrophages. Thus, Hcy appears to have immunomodulating and
pro-inflammatory activities.
Hcy (mmol/ml) 28.98 ±3.46 23.22 ±1.87 19.17 ±3.24 p<0.05

14. Biomaterials Research - Manfred Maitz

15. Biomaterials Research - Manfred Maitz

16. Biomaterials OOUURR RREESSEEAARRCCHH GGRROORUUePsPearch - Manfred Maitz
Dr. CHANG, SAADET, BETUL, SEDA, AYKUT,
DONIC, ALFUR, ART, JAMES, REBECCA, LEO

17. Biomaterials Ignore thoseR ewsheoa rcsha y- Myaonufr eddo M naoittz suck. They said to me jerks.
I gave shred the hands of atoms
Special Theory of Relativity (1905), Relativity (1920 and 1950), General
Theory of Relativity (1916), Investigations on Theory of Brownian Movement
(1926), and The Evolution of Physics (1938). Among his non-scientific works,
About Zionism (1930),
Why War? (1933), My Philosophy (1934), and Out of My Later Years (1950).