Disease of prions

3. How do the abnormal PROTIENS are
diagnosed without having a Nucleic Acids
???????

4. Overview :-
 Symptoms of prion disease
 How are diagnosed
 Diseases in Animals
 Diseases in Humans
 Cure
 Prevention

5. Symptoms of prion disease :-
Rapidly developing DEMENTIA
Difficulty in walking
Hallucination
Muscle stiffness
Confusion
Fatigue
Difficulty in speaking

6. Howarepriondiseasesdiagnosed??????
 There is no Blood test to detect its presence
 Only some methods :-
1. Microscopic Examination of Brain Tissue
2. MRI scans of the brain
3. Samples of the fluid from spinal cord
4. Electroencephalogram , which analyze brain waves

7. Prion’s diseases :-
humans Animals
 KURU disease
 CJD
 GSS
 FFI
 Scrapie
 Mad cow disease
 Chronic wasting disease

8. Scrapie :-
 Intense itching to
make sheep scrap off
their wool
 A natural
progressive brain
disease

9. Mad cow disease:-
 Bovine Spongiform Encephalopathy
 Cattle experience progressive degeneration of nervous
system
 Affected animal show changes in temperament , aggression ,
abnormal posture
 take 2 weeks to 6 months

12.  IN 1992/ 93 1,80,000 sheep affected
 4.4 million cattle were slaughtered
 In 1995 , 178 deaths
 1 In 2000 people in uk is carrier

13. Chronic wasting disease :-
 Neurological disease
 In deer , elk and moose
 cause emaciation , abnormal behavior ,loss of
bodily function and death

15. Kuru’s disease :-
 Means “ TREMBLING ”
 Lose the ability to walk , talk
or see

16. cooking does not effect it cause it
can survive 200 c temperature for 1-
2 hours

17. Mad cow disease In humans :-
 known as Creutzfeldt-Jacob disease
 caused by BSE of animals
 Fatal neurodegenerative disease
 seizures , dementia and incoordination
 Die within 6 to 12 months after symptoms appear

19. GSS disease :-
o Gerstmann-Straussler -Scheinker
o Fatal Neurodegenerative disease
o From 20 to 60 age
o Weakness in legs , Poor reflexes ,
Slowness of thought process , Deafness ,
Abnormal eye movement , Slurred speech

20. Alzheimer disease
is a double prion
disorder

21. Ffi disease :-
 Fatal Familial Insomnia
 Rare degenerative brain
disorder
 Inability to sleep
 Which worsen leading to
physical and mental
deterioration
 effect involuntary body
processes such as regulation
of heart rate ,sweating ,
breathing , and body
temperature

22. Interesting information:-
 Familial 15%
GSS , FFI
 Sporadic 85%
CJD
 Infectious rare
KURU ,BSE

23. “ There is no cure of prions diseases
“

24. Prevention :-
 Proper sterilization of medical
equipment's
 If you have CJD then don’t donate
organs or tissues

25. ANY QUESTION
????