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RFAP Matrix
1. RFAP™ Matrix
Powder Formulation for Extremely Insoluble Oral Drug Candidates
Nearly half of new drug candidates in development are poorly soluble compounds. Of these,
many are extremely insoluble and lack any appreciable water or oil solubility, making them
unformulatable using conventional approaches.
To overcome this high hurdle, LATITUDE Pharmaceuticals, Inc. is offering its new Rapidly-
dissolving, Free-flowing Amorphous Particle (RFAP) Matrix formulation. This approach
uses GRAS-listed materials to formulate particularly challenging compounds into a rapidly-
dissolving yet highly stable matrix. In addition to its desirable pharmaceutical properties, the
matrix is a fine, freely-flowing powder that is ideal for automated tableting.
Key Features of the RFAP Matrix:
Greatly improves oral BA
Applicable for drugs that are insoluble in oil, water
or both
Rapid dissolution
High drug loading (10-20%)
Thermodynamically stable amorphous drug form
Does not revert to crystal form (at least ~1.5 yrs)
Simple manufacturing process
Dose as powder or in capsules
Low cost of goods
Automated tableting-capable
Patent pending
LATITUDE Pharmaceuticals, Inc. | 9675 Businesspark Ave, San Diego, CA 92131 |Tel: 858-546-0924 | Fax: 858-546-0958 | www.latitudepharma.com