Rheumatic fever is a multisystem disorder that can occur as a consequence of untreated pharyngeal streptococcal infection. It develops in approximately 3% of individuals 2-3 weeks following a streptococcal infection. Rheumatic fever is diagnosed based on the updated Jones criteria, which requires two major criteria or one major and two minor criteria, along with evidence of a previous streptococcal infection. Major criteria include polyarthritis, carditis, chorea, subcutaneous nodules, and erythema marginatum. Minor criteria include fever, arthralgia, elevated acute phase reactants, prolonged PR interval, and leukocytosis.

1. BY- Dr ANMOL RAHEJA

2.  Is a multisystem disorder
Follows pharyngeal streptococcal infection.
This is the commonest cause of Acquired
Heart Disease in childhood and
adolescent .

3. It occurs in about 3% individuals who
develop pharyngeal infection with certain
serotypes of Group A.streptococci

4.  fever,
 lethargy,
 anorexia and
****symptoms caused due to involvement of
1. heart,
2. joints,
3. Skin
4. central nervous system.
These manifestations occurgenerally 2-3 weeks after streptococcal
pharyngitis.
Its diagnosis is based on updated Jone’s Criteria
Presence of two or more major criteria or one major and
atleast two minor criteria plus evidence of previous streptococcal
infection is required for the diagnosis of ARF

5.  for diagnosis of rheumatic fever
 Major criteria
 Polyarthritis
 Carditis
 Chorea
 Subcutaneous nodules
 Erythema marginatum
 Minor criteria
 Fever
 Arthralgia
 Raised ESR or CRP
 Prolonged PR interval And Leukocytosis
 ** Positive throat culture for Streptococci or elevated or Increasing streptococcal antibody titer

6. The blood examination reveals
1. leukocytosis,
2. raised ESR and CRP.
3. •Throat swab culture may be positive for group A
streptococci.•Anti-streptolysin O (ASO) titer is
raised to >200 unitsin adults or >300 unit in
children.
4. •Other antibodies like anti-deoxyribonuclease B
and anti-hyaluronidase may also be helpful in the
diagnosis.
5. •Chest radiograph,
6. ECG, and echocardiography are helpful in the
diagnosis of carditis.