Genomic sequencing is growing at a rate of 100 million sequences a year, which translates into 40 EB by the year 2025. It is daunting to meeting the challenge of handling this level of growth and perform big data analytics. In this session, learn how one genomics company is now able to increase their sequencing capacity by 20x using NetApp Cloud Volumes for AWS. Understand how they can now perform sequencing at an extremely fast rate and complete analysis at a global scale.

1. Engineering Genomic Big
Data Analytics at A Global
Scale
© 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —
Elio Gerardi
NetApp Cloud Solutions Architect
July 17, 2018

2. Data analytics driving transformation of genomics industry
© 2018 NetApp, Inc. All rights reserved.
… while enabling
data-driven digital
transformation
MASSIVE DATA GROWTH
100 million to two billion genomes
driving 40 Exabytes of data by 2025*
EFFICIENT RESOURCE USAGE
Budget constraints driving optimization of
infrastructure with the flexibility to freely
scale as business demands
CONSTRAINED PACE OF
INNOVATION
Demand for on-demand
resources at odds with
performance requirements
2
1000GB=1TB, 1000TB=1PT, 1000PT=1EB
* Source: PLOSBiology

3. ▪ Time is money – need to process more
sequences, faster
▪ Need the flexibility of the cloud to scale for
an increasing genomic workload
▪ Need a high-performance
analytic environment
▪ Need to spend less time managing
infrastructure and control growing cost
Challenge of doing genomic sequencing at scale
3 © 2018 NetApp, Inc. All rights reserved. --- NETAPP CONFIDENTIAL ---
Using sequence data to improve health for people around the world.

4. Current cloud sequencing architecture
▪ Massive file-based data set for analysis
▪ AWS global data center locations enable
global sequencing footprint
▪ Data set supported across roll-your-own
NFS services on Amazon Elastic Compute
Cloud (EC2) and Amazon Elastic Block
Storage (EBS)
▪ Current architecture supports 48,000
parallel sequences
▪ Always looking for more performance
Reduce complexity and increase performance with NetApp Cloud Volumes
4 © 2018 NetApp, Inc. All rights reserved.
Sequencer
Output Data
NFS Servers
(Amazon EC2/Amazon EBS)
Sequencing Codes

5. NetApp
Cloud Volumes
Cloud-native file
services with fast
performance
Finally run any workload in AWS - even legacy apps – for maximum agility
Multiprotocol support in a multi-tenant service from AWS
Shift expense from CapEx to OpEx
Data protection without application performance impact
Clone Dev/Ops workspaces instantly and space-efficiently for faster releases
Replicate across geographies for global data access and protection
Get workloads to AWS cloud
months or even years sooner

6. NetApp Cloud Volumes Service overview
Cloud-native file services built to run on AWS
6 © 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —
Availability and durability
▪ High durability (7 nines)
▪ High availability (4 nines)
Scalability
▪ 100 TB per file volume
▪ 100s of shares per subscription – 1,000s of clients per share
▪ Multiple VPCs supported
Rich data management
(add-on services)
▪ NetApp Snapshot copies, restore, and clones
▪ Cross-region and hybrid-cloud backup and replication with NetApp data movers
Security
▪ Data at rest encryption
▪ Secure multitenancy, Active Directory, and (LDAP) integration export policies
▪ File share access can be restricted based on instance or IP range (through export policies)
Performance
▪ Multiple service levels (one per volume) to match application needs
▪ Low latency, consistent performance
Simple, on-demand
file share
▪ NFS v3, v4, and v4.1
▪ SMB 3.0 and 3.1.1

7. Cloud Volumes Provides Excellent Performance
7 © 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —
Cloud Volumes Cloud Volumes Value
Latency milliseconds Ability to run applications that demand high performance
Per volume
Throughput (1TB)
16MB (Standard)
65MB (Premium)
130MB (Extreme)
Control cost: No need to overprovision capacity to achieve
performance
• Performance numbers based on NetApp test environment with multiple
instances connecting to one session
Consistency
Consistent latency
across capacities
NetApp service level objectives (SLO) provide application user
expectations all the time
Flexibility
Non-disruptive
performance level
change
Flexibility to switch service levels on the fly – at any time –
without requiring a data migration.

8. ▪ File-based dataset resides on AWS-hosted
NetApp Cloud Volumes
▪ Analytics running on Amazon EC2 services;
Amazon EBS; Amazon VPC; MongoDB
▪ Saving time and money, no longer need to
manage custom infrastructure
▪ Complete cloud offering with no versions or software to
manage
▪ Cloud Volumes service offers advanced data
management—built in
High-performance, cloud-based sequence analysis
Reduce complexity and increase performance with NetApp Cloud Volumes
8 © 2018 NetApp, Inc. All rights reserved.
Cloud Volumes
Sequencer
Output Data
Sequencing Codes

9. ▪ 20X more sequencing capacity with the same
dataset compared to previous capability
▪ Able to run a large calculation in 45 minutes​
with NetApp Cloud Volumes in AWS
▪ 3x faster than previous capabilities for​ three NFS
servers and15 Amazon EBS volumes​
▪ Easy onboarding: 30TB and 2M files in place
in less than 2 days​
Results with NetApp Cloud Volumes
9 © 2018 NetApp, Inc. All rights reserved. --- NETAPP CONFIDENTIAL ---
Increasing sequencing capacity for more rapid genome results

10. Cloud Volumes Demo
10 © 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —

11. NetApp Cloud Data Services
Inspire innovation in the cloud with industry-leading data services stack
© 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —
ONTAP Data Management
Backup, Protection, Security, and so on
NetApp Cloud Controls
NetApp Cloud Insights
Cloud
Storage
Software-as-a-
Service (SaaS)
Applications
On-
Premises
11
25 years of on-
premises and
private cloud
storage solutions
• Modernize with All
Flash Arrays
• Build clouds with
hyper-converged
infrastructure (HCI)
NETAPP
DATA
FABRIC

12. 12 © 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —
Disaster
Recovery
Backup and
Archive
Analytics and
Data Lakes
DevOps
App Dev
Production
Workloads
File
Services
SaaS
Applications
Data Services that Accelerate All Your Cloud Workloads

13. Summary
▪ Sign up and try Cloud Volumes for AWS today
https://netapp.com/aws
▪ Learn more at www.netapp.com/cloudvolumes
NetApp Cloud Volumes delivering
fast performance for genomic
sequencing…
…While saving cost and
manpower in the process
Cloud-native file services with
extreme performance

14. 14
Thank You
© 2018 NetApp, Inc. All rights reserved. — NETAPP CONFIDENTIAL —