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Alteplase aliquots
1. (1) College of Pharmacy Chicago Rockford
website & (2) drugs.com website
ALAA ALWAZNI,DRUG INFORMATIONCENTER
Storage instructions:
Activase:Store intact vials at room temperature (not to exceed 30°C) or under
refrigeration at 2°C to 8°C (36°F to 46°F); protect from light. Store reconstituted
solution at 2°C to 30°C and use within 8 hours. Discard any unused solution (2)
Cathflo Activase:Store intact vials at 2°C to 8°C; protectfrom light. Store
reconstituted solution at 2°C to 30°C and use within 8 hours. Discard any unused
solution.
Details, reference studies about alteplase aliquot’s storage
Alteplase
vial
Aliquot
conc.
Total
aliquot
vol.
Container Storag
e
temp.
Storage
time
Restored
function
%
References
50mg
vial
1mg/ml 2ml sterile plastic
syringe
-20°C up to 6
months
87.25 Dietcher et al
(1)
50mg
vial
1mg/ml 2.5ml 5ml sterile
vial
-20°C 1 month 81 Timoney et al
(1)
50mg
vial
1mg/ml 2ml 10ml sterile
glass vial
-20°C 26 days in all. Isaac (1)
Generali (2)
50mg
vial
1mg/ml 1ml - -30°C up to 12
months
77 Alkatheri et al
(1)
100mg
vial
0.5mg/
ml
1ml 5ml plastic
syringes
-25°C up to 14
days
over 90
for 48
hrs
Davis et al
(1) (2)
1mg/ml 2°C up to 14
days2mg/ml
50mg
vial
1mg/ml 1.5ml 2ml syringe -30°C up to 5
months
over 95 Wiernikowski
et al (1)
Generali (2)
50mg
vial
1mg/ml 1ml polypro-
pylene tube
-20°C 6 months over 95 Calis et al (1)
Generali (2)
2ml 5ml vial -70°C 14 days over 95
Alteplase (Activase®)
Storage of Aliquot