1. Mo#va#on and Background
Formula(ng and Op(mizing Thiol-Vinyl Systems As Ophthalmic Adhesives
Adora Yabut1, Devatha Nair1, Christopher Bowman1
1Department of the Chemical And Biological Engineering of the University of Colorado Boulder
A formula#on that is water-insoluble,
rela#vely hydrophilic, and degrada#on
controlled has yet to be established.
Therefore, the project goals are to:
• to find an adhesive formula(on of a
thiol-vinyl system that cures under
wet condi(ons that can ul(mately
help simplify the vitrectomy
procedures for re(nal reaMachment.
• characterize the hydrophilicity of the
network and the crosslinking densi(es
of the formula(ons.
Results
Materials and Methodology
Conclusion
• The thiol-vinyl system comprised of TMPTMP (trithiol) and TATATO
(vinyl) was found to have the least amount of swelling.
• The TMPTMP:TATATO sample’s smaller average molecular weight
distances between crosslinkings, in comparison to the other
formula(ons, formed a more (ghtly bounded polymer networks that
provided a smaller matrix for the solvent molecules to enter when the
sample was submerged in the solvent.
Future Studies
• Change the func(onality of the thiol and vinyl monomers in the materials
to control the degrada(on of the material.
• Conduct the swelling tests at body temperature to study the swelling and
degrada(on of the materials.
• Re(na: light-
sensi(ve layer
of (ssue that
lines the back
surface of eyes.
• D u e t o
liquefac(on and
trac(on, the
adhesion at the
v i t r e o r e ( n a l
interface cause
detachment.
• The data above compares the different polymer network systems: ETTMP:TATATO, PETMP+ETMMP:TATATO, and
TMPTMP:TATATO.
• Comparison of the hydrophilicity of the systems, average molecular weight between crosslinkings, and volumetric
changes are also demonstrated.
Goniometer Data
• Stoichiometric monomers formula(ons are
mixed in a hot bath, and cured via UV lamp at
5mW/cm2
• measures the contact angle that is formed
on the solid-liquid interface.
• Calculates the average molecular weight
between crosslinkings.
Acknowledgements:
• Devatha Nair
• Christopher Bowman
• Here, our
t h i o l -
v i n y l
systems
comprise
o f 3
different
t h i o l s ,
ETTMP,
PETMP, TMPTMP, that are free radically
polymerized with the vinyl TATATO.
0"
0.05"
0.1"
0.15"
0.2"
0.25"
0.3"
0.35"
0.4"
0.45"
0" 5" 10" 15" 20" 25"
VOLUME'INCREASED'(IN'DECIMALS)'
TIME'(DAYS)'
VOLUME'CHANGES'OF'THE'POLYMER'NETWORKS''
'
ETTMP"
ETTMP+PETMP:TATATO"
TMPTMP:TATATO"