Immunosuppressant is a class of medicines that inhibit or decrease the intensity of the immune response in the body. Most of these medications are used to allow the body less likely to resist a transplanted organ. In solid organ transplantation, immunosuppressive agents are needed for the activation of early-stage immunosuppression, the management of late-stage immunosuppression or for the maintenance of organ rejection. The emergence of novel agents and improvements in immunosuppression regimens after transplantation are significant factors leading to this progress. However, these drugs also increase the risk of infection, cancers and specific adverse side effects specific to each agent in patients particularly in pregnant women and fertility issues. Corona virus disease being hot topic of debate is has given positive outcome to immunosuppressive drugs however need more attention in future.

1. Immunosuppresant
Student Name:- Abhishek Borkar
Class- B- pharm 3rd year
ShraddhaInstitute of PharmacyKondala zambre , Washim-444505

2. Defination :-
Immunosuppresant an agent that can
suppress or prevent the immune response
.
 Immunosuppresant are used to prevent
rejection of a transplanted organ and to
treat autoimmunsuppresent diseses such
as psoriasis .rheumatoid arthritis and
crohnic disease .

3. In transplantation the main categorie, of
immuno supresive drugs :-
Gluco Corticoids
Calcineur inhibitors
 Antimetabolic agents
Antibodies
These drugs have accomplished an elevated level of
Clinical achievement in treating Conditions such as sevex
immune rejection of organ transplants and harsh auto-
immun aliment

4. Principal of Immung suppresant Therapy :-
 immune rectivity and the probability of graft
rejection are maximum infinity and decress over
time
Use low dose of a number of drug with non -
overlaping toxicity .
Avoid over immunosuprssion drug region which
augment vulnerability to infection and malignancy

5. Classification :-
 Conventional agents :
 Conticostroids : e.g. Prednisone.
Antimetabolites eg. Mycophenolate
Calcineurin inhibitors: eg cyclosporin and Tacrolimus
mTOR inhibitors: e.g. Sirolimus & Evero limus
Antibody reagents:
IL-2 receptor antagonist antibody eg. Basiliximab
Polycolanal anti-thymocyte antibadle eg. Anti-thymocyte
globulin
Manoclonal anti-thymocyte antibodie eg. Alemtuzumab

6.  1. Prednisone:
 Manket Name. : meti conten R
 class :- Immunosuppressant
 M.O.A :- Prednison itself is in inactive foam form and should be Converted to
Prednisolon, by hepatic dehydrogenas So that glucocorticoid receptors. 11-B hydroxy
strold it can bind to
 Chief mechanism include:
inhibit PLA2.
Suppression of Cax-2
Decreasses The activity of immune system
Reduction of reactions of inflammtory Cytokinase.
modify the actions many tissue of variouous gene in many tissue

7. USES :-
1. Endocrine disorder
2. Pheumatic disorder
3. Collages disorder
4. Dermatologi disorder
5. Respiratory disorder
6. Hematologic disorder
7. GI disorder
8. prevent transplant rejection.
9. Neoplastic rejection

8. Contraindications :-
1.It is avoid Systemic fungal infection.
2.Not used when Hypersenstivity
2. Basiliximab :-
Market Name . Simulect Ⓡ
Class → Monoclonal Antibody
M.O.A - A human. That Subunit monoclonal antibody
particurly binds to the alpha The interleukin-2
reeptor.Stimulated T cells.Produc. inhibition of T cell
proliferation f differentiation, but T cells are not pun down.
Rund
P'Kinetics: Adminished I.V bolus Infusion : 25-30 minutes

9. THANK YOU ……