INTRODUCTIONS ADVANTAGES OF GRDDS DISADVATAGES OF GRDDS FACTORS CONTROLLING GASTRIC RETENTION OF DOSAGE FORMS APPROACHWS FOR GRDDS APPLICATIONS OF GASTROADHESIVE SYSTEM

1. KARNATAKA COLLEGE OF
PHARMACY
NOVEL DRUG DELIVEREY SYSTEM
SEMINAR TOPIC:
GASTRO-RETENTIVE DRUG
DELIVERY SYSTEM
PRESENTED BY: Mr. ABDALLAH ABDALMALK
UNDER GUIDANCE OF Dr. Usha
Email: ABDALLAHABDALMALK@YAHOO.COM
23/10/2020
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2. • INTRODUCTIONS
• ADVANTAGES OF GRDDS
• DISADVATAGES OF GRDDS
• FACTORS CONTROLLING GASTRIC RETENTION OF DOSAGE
FORMS
• APPROACHWS FOR GRDDS
• APPLICATIONS OF GASTROADHESIVE SYSTEM
CONTENTS:
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3. • Gastro-retentive drug delivery system (GRDDS) has gained immense
popularity in the field of oral drug delivery recently.
• It’s widely employed approach to retain the dosage form in the stomach for
extended period of time and release the drug slowly that can address many
challenge associated with conventional oral delivery including poor
bioavailability.
• Different innovative approaches like magnetic field assisted gastro-
retention plug type swelling system, muco-adhesion techniques, floating
system with or without effervescence are being applied to fabricate
GRDDS.
INTRODUCTIONS:
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4. 1. Enhanced bioavailability
2.Reduced frequency of dose
3.Targeted therapy for local aliments in the upper GIT.
4.Patient compliance.
5.Improved therapeutic efficacy.
ADVANTAGES OF GRDDS:
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5. 1. Requirement of high level of fluid in stomach for the delivery
system to float and work efficiently.
2.Requires present of food to delay gastric empting.
3.Drugs which undergo first pass metabolism may not be desirable
candidates for floating DDS since the slow gastric empting .
4.It will leads to alter systemic bioavailability.
5.Drugs having solubility or stability problems in the highly acidic
gastric environment or which are irritant to gastric mucosa cant
be formulated as GRDDS.
DISADVATAGES OF GRDDS:
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6. a.Density of dosage form.
b.Shape and size of dosage form
c.Food intake and nature of food
d.Effect of gender, posture and age
FACTORS CONTROLLING GASTRIC RETENTION OF DOSAGE
FORMS:
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7. 1. Floating drug delivery system
2. Mucoadhesive system
3. Swell able system
4. High density system
APPROACHES FOR GRDDS:
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Fig: types of gastro retentive drug Delivery
system

8. • Floating system can be classified into two categories each class has subclasses:
1. Effervescent
a. Gas generating system
b. Volatile liquid containing system
c. Inflatable GIDS
d. Intra gastric osmotically controlled drug delivery system
2.Non-Effervescent
a. Colloidal gel barrier system
b. Alginate beads
c. Hollow microspheres
d. Microporous compartment system.
 Floating drug delivery system:
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9. a. Gas generating system
• Intra gastric single layer floating tablets or hydrodynamically balanced
system (HBS).
1.Effervescent:
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10. b. Volatile liquid/vacuum contains system
• These system can be made to float in the stomach
becaus of floatation chamber which maybe
a vacuum or field with air or a harmless
gas, while drug reservoir is encapsulated
inside microporous compartment.
CONTIN…
Mr. Abdallah abdalmalk
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Fig: vacuum contains
system

11. c. Inflatable gastrointestinal delivery system
• In this system an inflatable chamber is
incorporated which contains liquid ether
that evaporate at body temperature to
cause the chamber to inflate in the stomach.
• The system is fabricated by loading the inflatable
chamber with drug reservoir which can be
a drug impregnated polymeric matrix then
encapsulated in a gelatine capsule.
CONTIN…
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Fig: Inflatable GIDS

12. d. Intra gastric osmotically controlled drug delivery system
• It’s comprised of an osmatic pressure-controlled drug delivery device and an inflatable
floating support in biodegradable capsule.
• I stomach the capsule quickly disintegrates to release the intrinsic osmotically
controlled drug delivery device.
CONTIN…
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Fig: Intra gastric osmotically controlled drug
delivery system

13. 1. Enhanced bioavailability
2.Sustained drug delivery reduced frequency of dose
3.Target therapy for local ailments in the upper GIT.
4.Reduced fluctuation of drug concentration.
APPLICATIONS OF GASTROADHESIVE SYSTEM:
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