This is my first presentation in my masters (M.Pharm) on the gastro-retentive drug delivery system, strictly for presentation, i.e., minimal and accurate content.
2. Table of Contents
Introduction
Approaches for gastro-retentive drug delivery systems
Low density system
Bio-adhesive system
Hight Density system
Advantages
Disadvantages
Applications
3. Introduction
GRDDS stands for Gastro-retentive Drug
Delivery Systems. It is a novel drug delivery
system that can persist in the stomach for a
prolonged period of time, thereby increasing
the gastric residence time (GRT) of drugs.
4. Need for Gastro-retentive drug
delivery system:
Drug that are less soluble and degenerate in alkaline pH.
Drug that are absorbed due to variable gastric emptying
time.
6. Floating System
The Floating Density
Drug Delivery System
(FDDS) in Gastro-
Retentive Drug Delivery
Systems (GRDDS) is a
system where the bulk
density of the dosage
form is lower than that
of gastric fluids.
7. Density must be <1 g/cm3
It works on the principle of Bouyancy force
F= F bouyancy- F gravity
Based on the mechanism of buoyance , two technologies are used:
a) Non- Effervescent
b) Effervescent
8. Non-Effervescent
The Non-Effervescent system in Gastro-Retentive Drug Delivery
Systems is a type of floating drug delivery system. It includes the
blending of the medication with a gel, which swells when it interacts
with gastric fluid.
Some examples of Non-Effervescent systems include:
•Colloidal gel barrier systems
•Alginate beads
•Hollow microspheres
9. Effervescent
The Effervescent system in Gastro-Retentive Drug Delivery
Systems is a type of floating drug delivery system. It involves the
use of effervescence agents, such as sodium
bicarbonate(NaHCO₃), that generate gas (CO2) in response to
the acidic environment in the stomach.
10. Bioadhesive system
The Bioadhesive system in Gastro-Retentive Drug Delivery
Systems (GRDDS) is a type of drug delivery system that
extends the gastric retention time by adhering to the gastric
mucosa membrane
11. High density system
High Density Systems in Gastro-Retentive Drug Delivery
Systems (GRDDS) are designed to have a density greater than
the gastric contents, which allows them to sink to the
bottom of the stomach, the density is about 3 gm/cm3
12. ADVANTAGES
• This system offers improved Bioavailability.
• Safest root of administration.
• Local action can be achieved.
13. DISADVANTAGES
• This system should be administrated plenty of
water.
• Drug with solubility and stability problem are not
suitable.
