Treatment of h.pylori

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Abdallah El Gameel

Different regimen in treatment of H.pylori

Health & Medicine

Strategy of treatment
Selectivity Spectrum Duration Dose
Clarithromycin
Amoxicillin
metronidazole
Tetracycline
Levofloxacin
Bacteriostatic
??????
Bacteriostatic
Bactericidal
Bactericidal
14days
500 mg ...2T/D
500 mg ...2T/D
500 mg ...4T/D
500 mg ...2T/D
1000mg ..2T/D

Bismuth subcitrate potassium
Direct antimicrobial action
Effective against H.Pylori
525 mg …..4T/D
Strategy of treatment
Proton pump inhibitor
Omeprazole…..20mg....20T/D
Lansoprazole….30mg…20T/D

Regimen
Clarithromycin
Clarithromycin-triple therapy
Bismuth-quadruple therapy
Bismuth
Tetracycline
metronidazole

Regimen
Levofloxacin therapy
Levofloxacin Amoxicillin
Antimicrobial susceptibility test

Bismuth
Tetracycline
metronidazole
Bismuth-quadruple therapy
Regimen
Non-Bismuth-quadruple therapy
Clarithromycin
Amoxicillin
metronidazole

Regimen
Sequential therapy
Amoxicillin
Clarithromycin metronidazole

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Treatment of h.pylori

2. Recurrence….. 20% Eradication….. 80%

3. Strategy of treatment Selectivity Spectrum Duration Dose Clarithromycin Amoxicillin metronidazole Tetracycline Levofloxacin Bacteriostatic ?????? Bacteriostatic Bactericidal Bactericidal 14days 500 mg ...2T/D 500 mg ...2T/D 500 mg ...4T/D 500 mg ...2T/D 1000mg ..2T/D

4. Bismuth subcitrate potassium Direct antimicrobial action Effective against H.Pylori 525 mg …..4T/D Strategy of treatment Proton pump inhibitor Omeprazole…..20mg....20T/D Lansoprazole….30mg…20T/D

5. Regimen Clarithromycin Clarithromycin-triple therapy Bismuth-quadruple therapy Bismuth Tetracycline metronidazole

6. Regimen Levofloxacin therapy Levofloxacin Amoxicillin Antimicrobial susceptibility test

7. Bismuth Tetracycline metronidazole Bismuth-quadruple therapy Regimen Non-Bismuth-quadruple therapy Clarithromycin Amoxicillin metronidazole

8. Regimen Sequential therapy Amoxicillin Clarithromycin metronidazole

9. Regimen Levofloxacin therapy Levofloxacin Amoxicillin Antimicrobial susceptibility test