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Abstract Imaging of macromolecules and organelles in the context of cells and tissues is challenging because of the different scales and big data sharing. High resolution imaging of ultrastructure using electron microscopy (EM) typically has a small field of view. Panorama EM views, which we name nanotomy (nano-anatomy), now cross orders of magnitude scales (http://www.nanotomy.org). The open-source sharing allows reuse of data for further analysis, e.g. of structures that were not the focus of the primary study. Nanotomy will likely become the future standard routine EM technique for tissue and cell imaging. In this talk I will highlight the technique and the recent database of nanotomy of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes. Research: cellbiology.nl lEM-dbase: nanotomy.org UMIC core: umic.info Presenter: Ben N. G. Giepmans, PhD, Associate Professor, Biomedical Sciences of Cells & Systems, UMC Groningen, The Netherlands Upcoming webinars schedule: https://dknet.org/about/webinar
dkNET Webinar - nPOD Nanotomy: Large-Scale Electron Microscopy Database For H...
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It is a paper published in Nature Biotechnology on 11 July 2016 that showed some novel driver genes that induce metastasis.
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Francesca MALVESTITI, Ph.D., ErCLG Citogenetica Molecolare, TOMA Advanced Biomedical Assays, S.p.A. fmalvestiti@tomalab.com Present an historical overview of the modern molecular cytogenetics Present the principal assays to detect submicroscopic copy number variations (CNV) on fetal samples Describe pros and cons of targeted vs genome-wide methods Present additional yield for pCNV by microarray analysis in anatomically normal and abnormal fetuses with normal karyotype
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