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Genetically modified organisms
            (GMO)
History


    1986 - First field trials of genetically engineered plants

    1994 - GMO Hits Grocery Stores

    1996 - GMO-Resistant Weeds

    1997 - Mandatory Labels in EU

    1999 - GMO Food Crops Dominate

    2003 - GMO-Resistant Pests

    2011 - Bt Toxin in Humans
GMO Today
Top GMO producer countries
Pros


    Herbicide and insecticide included

    Higher crop yield

    Can be grown in monoculture,
    no need for rotation

    Extra properties can be added, e.g. producing
    more vitamin A → Golden rice
Cons


    General testing do not reveal long-term effects!

    Bt toxins are produced by every cell and it's
    accumulating both in the plant and the soil

    Herbicide and insecticide resistance developed
    by weeds and insects

    Gene transfer to other organisms

    Seeds must be bought each year

    Decreasing biodiversity
The „Pusztai affair”

In 1998 Árpád Pusztai said in                        observed
                                           an interview on a World in Action programme that his group had


damage to the intestines and immune systems of rats fed the
genetically modified potatoes.

              If I had the choice
He also said, "

             I would certainly not eat it,"

and that, "I find it's very unfair to use our fellow citizens as
guinea pigs."

 In 2005, he received the   Whistleblower Award                from IALANA

          In 2009, Pusztai and his wife received the Stuttgart peace prize (Stuttgarter
          Friedenspreis)
StarLink corn controversy


 StarLink is a variety of Bt corn, intended for use in animal feed.
 U.S. regulatory authorities permitted the commercial sale of
 StarLink seed with the stipulation that crops produced must not
 be used for human consumption. This restriction was based
 on the possibility that a small number of people might develop an
 allergic reaction to the Bt protein used in StarLink that is less
 rapidly digested than the version used in other Bt varieties.
 StarLink corn was subsequently found in food destined
 for consumption by humans. An episode involving Taco Bell
 taco shells was particularly well publicized. This led to a public
 relations disaster for Aventis and the biotechnology industry as a
 whole. Sales of StarLink seed were discontinued in 2000.
Genetically modified crops safety
assessments (2011)
 We reviewed 19 studies of mammals fed with commercialized genetically modified soybean and maize
 which represent, per trait and plant, more than 80% of all environmental genetically modified organisms (GMOs)
 cultivated on a large scale, after they were modified to tolerate or produce a pesticide. We have also obtained the raw
 data of 90-day-long rat tests following court actions or official requests. The data obtained include biochemical blood
 and urine parameters of mammals eating GMOs with numerous organ weights and histopathology findings.
 Methods
 We have thoroughly reviewed these tests from a statistical and a biological point of view. Some of these tests used
 controversial protocols which are discussed and statistically significant results that were considered as not being
 biologically meaningful by regulatory authorities, thus raising the question of their interpretations.
 Results

 Several convergent data appear to  indicate liver and kidney problems                             as end points of
 GMO diet effects in the above-mentioned experiments. This was confirmed by our meta-analysis of all the in vivo
 studies published, which revealed that the kidneys were particularly affected, concentrating 43.5% of all disrupted
 parameters in males, whereas the liver was more specifically disrupted in females (30.8% of all disrupted parameters).
 Conclusions
 The 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers
 could be the onset of chronic diseases. However, no minimal length for the tests is yet obligatory for any of the GMOs
 cultivated on a large scale, and this is socially unacceptable in terms of consumer health protection. We are suggesting
 that the studies should be improved and prolonged, as well as being made compulsory, and that the sexual hormones
 should be assessed too, and moreover, reproductive and multigenerational studies ought to be conducted too.


 http://www.enveurope.com/content/23/1/10
Genetically modified crops safety
assessments (2011)
 We reviewed 19 studies of mammals fed with commercialized genetically modified soybean and maize
 which represent, per trait and plant, more than 80% of all environmental genetically modified organisms (GMOs)
 cultivated on a large scale, after they were modified to tolerate or produce a pesticide. We have also obtained the raw
 data of 90-day-long rat tests following court actions or official requests. The data obtained include biochemical blood
 and urine parameters of mammals eating GMOs with numerous organ weights and histopathology findings.
 Methods
 We have thoroughly reviewed these tests from a statistical and a biological point of view. Some of these tests used
 controversial protocols which are discussed and statistically significant results that were considered as not being
 biologically meaningful by regulatory authorities, thus raising the question of their interpretations.
 Results

 Several convergent data appear to  indicate liver and kidney problems                             as end points of
 GMO diet effects in the above-mentioned experiments. This was confirmed by our meta-analysis of all the in vivo
 studies published, which revealed that the kidneys were particularly affected, concentrating 43.5% of all disrupted
 parameters in males, whereas the liver was more specifically disrupted in females (30.8% of all disrupted parameters).
 Conclusions
 The 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers
 could be the onset of chronic diseases. However, no minimal length for the tests is yet obligatory for any of the GMOs
 cultivated on a large scale, and this is socially unacceptable in terms of consumer health protection. We are suggesting
 that the studies should be improved and prolonged, as well as being made compulsory, and that the sexual hormones
 should be assessed too, and moreover, reproductive and multigenerational studies ought to be conducted too.


 http://www.enveurope.com/content/23/1/10

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Gmo

  • 2. History  1986 - First field trials of genetically engineered plants  1994 - GMO Hits Grocery Stores  1996 - GMO-Resistant Weeds  1997 - Mandatory Labels in EU  1999 - GMO Food Crops Dominate  2003 - GMO-Resistant Pests  2011 - Bt Toxin in Humans
  • 4. Top GMO producer countries
  • 5. Pros  Herbicide and insecticide included  Higher crop yield  Can be grown in monoculture, no need for rotation  Extra properties can be added, e.g. producing more vitamin A → Golden rice
  • 6. Cons  General testing do not reveal long-term effects!  Bt toxins are produced by every cell and it's accumulating both in the plant and the soil  Herbicide and insecticide resistance developed by weeds and insects  Gene transfer to other organisms  Seeds must be bought each year  Decreasing biodiversity
  • 7. The „Pusztai affair” In 1998 Árpád Pusztai said in observed an interview on a World in Action programme that his group had damage to the intestines and immune systems of rats fed the genetically modified potatoes. If I had the choice He also said, " I would certainly not eat it," and that, "I find it's very unfair to use our fellow citizens as guinea pigs." In 2005, he received the Whistleblower Award from IALANA In 2009, Pusztai and his wife received the Stuttgart peace prize (Stuttgarter Friedenspreis)
  • 8. StarLink corn controversy StarLink is a variety of Bt corn, intended for use in animal feed. U.S. regulatory authorities permitted the commercial sale of StarLink seed with the stipulation that crops produced must not be used for human consumption. This restriction was based on the possibility that a small number of people might develop an allergic reaction to the Bt protein used in StarLink that is less rapidly digested than the version used in other Bt varieties. StarLink corn was subsequently found in food destined for consumption by humans. An episode involving Taco Bell taco shells was particularly well publicized. This led to a public relations disaster for Aventis and the biotechnology industry as a whole. Sales of StarLink seed were discontinued in 2000.
  • 9. Genetically modified crops safety assessments (2011) We reviewed 19 studies of mammals fed with commercialized genetically modified soybean and maize which represent, per trait and plant, more than 80% of all environmental genetically modified organisms (GMOs) cultivated on a large scale, after they were modified to tolerate or produce a pesticide. We have also obtained the raw data of 90-day-long rat tests following court actions or official requests. The data obtained include biochemical blood and urine parameters of mammals eating GMOs with numerous organ weights and histopathology findings. Methods We have thoroughly reviewed these tests from a statistical and a biological point of view. Some of these tests used controversial protocols which are discussed and statistically significant results that were considered as not being biologically meaningful by regulatory authorities, thus raising the question of their interpretations. Results Several convergent data appear to indicate liver and kidney problems as end points of GMO diet effects in the above-mentioned experiments. This was confirmed by our meta-analysis of all the in vivo studies published, which revealed that the kidneys were particularly affected, concentrating 43.5% of all disrupted parameters in males, whereas the liver was more specifically disrupted in females (30.8% of all disrupted parameters). Conclusions The 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers could be the onset of chronic diseases. However, no minimal length for the tests is yet obligatory for any of the GMOs cultivated on a large scale, and this is socially unacceptable in terms of consumer health protection. We are suggesting that the studies should be improved and prolonged, as well as being made compulsory, and that the sexual hormones should be assessed too, and moreover, reproductive and multigenerational studies ought to be conducted too. http://www.enveurope.com/content/23/1/10
  • 10. Genetically modified crops safety assessments (2011) We reviewed 19 studies of mammals fed with commercialized genetically modified soybean and maize which represent, per trait and plant, more than 80% of all environmental genetically modified organisms (GMOs) cultivated on a large scale, after they were modified to tolerate or produce a pesticide. We have also obtained the raw data of 90-day-long rat tests following court actions or official requests. The data obtained include biochemical blood and urine parameters of mammals eating GMOs with numerous organ weights and histopathology findings. Methods We have thoroughly reviewed these tests from a statistical and a biological point of view. Some of these tests used controversial protocols which are discussed and statistically significant results that were considered as not being biologically meaningful by regulatory authorities, thus raising the question of their interpretations. Results Several convergent data appear to indicate liver and kidney problems as end points of GMO diet effects in the above-mentioned experiments. This was confirmed by our meta-analysis of all the in vivo studies published, which revealed that the kidneys were particularly affected, concentrating 43.5% of all disrupted parameters in males, whereas the liver was more specifically disrupted in females (30.8% of all disrupted parameters). Conclusions The 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers could be the onset of chronic diseases. However, no minimal length for the tests is yet obligatory for any of the GMOs cultivated on a large scale, and this is socially unacceptable in terms of consumer health protection. We are suggesting that the studies should be improved and prolonged, as well as being made compulsory, and that the sexual hormones should be assessed too, and moreover, reproductive and multigenerational studies ought to be conducted too. http://www.enveurope.com/content/23/1/10