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ABDOMINAL PAIN


A presentation by Dr. Ravi Malik
CMD Radix Hospital
IMA headquaters
DMC medical education convenor
Ex President IMA East Delhi
Chief health news analyst
INTRODUCTION
ο‚— RAP
   ο‚— 3 episodes over 3 months
   ο‚— Severe enough
   ο‚— Inter periods
ο‚— No specific cause identified
epidemilogy
ο‚— 10-12% of school aged children.
ο‚— Peak incidence at 4-6 years and at 7-12 years.
ο‚— Obesity and RAP.
ο‚— Fruit consumption and RAP.
clinical profile
ο‚— Pain in genuine
ο‚— Peri-umbilical pain
ο‚— Nausea, vomiting
ο‚— Pallor
ο‚— Headache & limb pains
ο‚— Family history
classification
β€’ Recurrent abd. pain can be organic or nonorganic.
β€’ Nonorganic(functional) abd pain
   β€’ Functional dyspepsia
   β€’ Irritable bowel syndrome
   β€’ Abdominal migraine
   β€’ Aerophagia
   β€’ Functional abdominal pain.
ο‚— Functional dyspepsia
   ο‚— Pain or discomfort in the upper abdomen
   ο‚— Stomach fullness
   ο‚— Bloating
   ο‚— Nausea
   ο‚— Retching or vomiting.
ο‚— Irritable bowel syndrome
ο‚— Abdominal migraine
   ο‚— Intense abdominal pain
   ο‚— Mid-abdomen
   ο‚— Anorexia, nausea, vomiting, pallor, headache, or sensitivity to light
   ο‚— A family history of migraine
ο‚— Functional abdominal pain syndrome
pathophysiology
Gastrointestinal motility -High levels of emotional
  stress and abnormalities in autonomic nervous system
  which regulate gastrointestinal motility may
  contribute.
Visceral hypersensitivity -The intensity of the signals
  from the gastrointestinal system is exaggerated.
  Abnormal bowel sensitivity to physiological,
  psychologic or noxious stimuli may be present. This
  may occur following illnesses that cause inflammation
  in the intestine (e.g. viral gastroenteritis) or after
  psychologically traumatic events.
Emotional stress - Patients can sometimes date the onset of
  pain to a specific stressful event, such as change in school,
  birth of a sibling or separation of parents, family member's
  illess.
ο‚— Higher levels of anxiety and depression are found in
  patients with RAP than in healthy children.
ο‚— Starting school may also trigger recurrent abdominal pain.

Psychological factors:-
ο‚— A child can develop chronic abdominal pain related to his
  or her need for attention.
ο‚— Parental response to child's pain can reinforce the child's
  behavior. If parents are worried about child's pain, the
  child may become more anxious, and the pain may worsen.
ο‚— Parents should pay attention to the child's other activities,
  this might satisfy the child's need for attention & reduce the
  abdominal pain.
etiology
                          Organic Pain (10%)    Non-organic Pain (90%)
Site                      Flanks, suprapublid   Central and often
                                                epigastric
Family History                      - VE                  + VE
Psychological History               - VE                  + VE
Headache                            - VE                  + VE
Weight Loss                         - VE                  + VE
Abnormal Signs                      - VE                  + VE
Abnormal Investigations             - VE                  + VE
Alarming Symptoms                   - VE                  + VE
rop (organic)
ο‚— GIT
   ο‚— Infections – ameba, giardia, dysentry, H. pylori
   ο‚— Inflamatery – IBD, Hepatitis, appendicitis Dietory
     intolerance – lactess
   ο‚— Constipation
   ο‚— GI reflux disease
   ο‚— Acid peptic disease
causes of rop (organic)
Urinary tract       Gynecological   Miscellaneous

Urinary tract       Ovarian cyst
infection                           Abdominal
Urinary calculi                     epilepsy
                    Endometriosis
Pelvi-ureteric                      Physical,
junction            Pelvic          emotional and
obstruction         inflammatory    sexual abuse
Chronic             disease
pancreatitis
alarm symptoms
    Features that suggest an organic disorder may include one or
    more of the following:
ο‚—   Pain that awakens the child,
ο‚—   Significant vomiting/constipation/bloating
ο‚—   Persistent right upper/lower quadrant pain
ο‚—   Unexplained fever
ο‚—   Dysphagia
ο‚—   Chronic severe diarrhea
ο‚—   G.I. blood loss
ο‚—   Unintentional weight loss or slowed growth
ο‚—   Delayed puberty
ο‚—   Pain/ bleeding with urination
ο‚—   Family H/O inflammatory bowel disease, celiac or peptic ulcer disease
alarm signs
ο‚—   Localized tenderness in right upper/lower quadrant
ο‚—   Localized fullness or mass
ο‚—   Hepatomegaly/Splenomegaly
ο‚—   Jaundice
ο‚—   Costovertebral angle tenderness
ο‚—   Arthritis
ο‚—   Spinal tenderness
ο‚—   Perianal disease
ο‚—   Unexplained physical findings
ο‚—   Pallor/Rash
ο‚—   Hernia
ο‚— Absence of alarm symptoms & signs, a normal physical
  examination, and a normal stool hemoccult test is
  sufficient for an initial diagnosis of functional
  abdominal pain.
ο‚— Identifying organic abnormalities by comprehensive
  investigations does not necessarily mean that the
  explanation for the symptoms is found.
ο‚— Organic and non organic causes for RAP can co-exist
  in some patients.
diagnosis
ο‚— RAP should not require an exhaustive series of diagnostic tests to rule out
  organic causes of pain.
ο‚— History – absence of alarming symptoms
ο‚— Meticulous examination
ο‚— Other associated symptoms
ο‚— Normal investigations
investigations in recurrent abdominal pain
Basic investigations (1st line investigations)
ο‚— Full blood count
ο‚— ESR/C-reactive protein
ο‚— Urine analysis & Urine culture
ο‚— Stool for ova, cysts and parasites
Second line investigations
ο‚— Plain X-ray abdomen
ο‚— LFT & KFT
ο‚— Celiac panel
ο‚— Abdominal ultrasound
ο‚— Breath hydrogen test for lactose intolerance
ο‚— Tests for Helicobacter pylori
ο‚— Barium follow through
ο‚— Esophageal manometry and pH-metry
ο‚— Upper and lower gastrointestinal endoscopy
ο‚— Intravenous urogram/micturition cystourethrogram
ο‚— Only basic urine, stool and blood examinations are
  recommended to exclude organic causes in the
  diagnosis of RAP.
ο‚— Ultrasound scanning, extensive radiographic
  evaluation and invasive investigations like endoscopy
  in these children are rarely diagnostic or cost effective.
ο‚— Presence of an abnormal test result alone does not
  pinpoint to a diagnosis unless it is clinically relevant.
abdominal pain treatment
ο‚— If the initial evaluation suggests an organic disorder, the likely causes of
  pain will be investigated and a treatment plan will be developed.
ο‚— Chronic abdominal pain in children is most often caused by a functional
  disorder.
ο‚— There are a variety of treatments that can be helpful, but no single
  treatment is best. Most experts recommend trying several treatments.
ο‚— This may require several visits with the doctor, especially if pain has been a
  problem for a long time.
ο‚— The first goal of treatment is to help the child return to
  normal activities. A second goal is to improve the
  child's pain.
ο‚— It may take some time to figure out what is causing the pain
  and find the best treatment.
ο‚— A functional disorder does not mean that the child does
  not have pain or that it's "all in their head".
ο‚— It is important to build a good relationship with the
  parents, this will allow the doctor to explore stressors, try
  various treatments, and continue the evaluation when
  necessary.
ο‚— Acknowledge that the child's pain is real and offer
  sympathy, support, and reassurance. But also take care to
  avoid reinforcing the pain by giving it undue attention.
guidelines for management of recurrent abdominal
                      pain

ο‚— Rule out organic cause
ο‚— Reassurance & education of the family.
ο‚— Discuss the apprehensions of family.
ο‚— Explore stressors.
ο‚— Acknowledge but no undue attention.
ο‚— Avoid psychological labelling.
guidelines for management of recurrent abdominal
                    pain-(II)
ο‚— Allow normal activity.
ο‚— Establish regular follow-up system of return visits to monitor the
    symptoms.
ο‚—   Be available Assure parents that you are available to see the child if
    changes occur or the parents become anxious.
ο‚—   Allow appropriate time, in an unrushed environment for them.
ο‚—   Make judicious use of β€œsecond opinions”
ο‚—   With this approach, approximately 30% to 60% of children have
    resolution of their pain.
ο‚—   Remainder continue to exhibit symptoms and go on to be adults with
    abdominal pain, anxiety, or other somatic disorders.
pharmacological management
ο‚— Pharmacological treatments are commonly used in an effort to manage
  symptoms despite the lack of data supporting their efficacy.
ο‚— Antispasmodics & low dose amitriptyline are used.
ο‚— Famotidine (an H2-receptor antagonist) is effective in children with
  RAP who have predominantly dyspeptic symptoms.
ο‚— Pizotifen, a serotonin antagonist, has been found to be effective when
  used prophylactically in children with abdominal migraine.
Local remedies: Many local remedies are used to alleviate symptoms in
  children with RAP. Peppermint oil found to be very effective in the
  treatment of irritable bowel syndrome in children.
dietary modifications
ο‚— Treatment trials of fibre supplements and lactose
  restricting diets reveal a 50% decrease of pain
  episodes.
ο‚— In some children, there are foods, drinks, and
  medicines that make symptoms worse.
ο‚— Common triggers include: High-fat foods, Caffeine &
  foods that increase gas (beans, onions, raisins,
  bananas, apricots, prunes, cabbage, cauliflower,
  broccoli etc.)
ο‚— Medicines that can cause upset stomach include
  aspirin and ibuprofen etc.
behavioral therapies
ο‚— Recommended for children or adolescents with functional
  abdominal pain that has severely impacted activities of
  daily living.
ο‚— Cognitive-behavioral therapy, hypnosis, biofeedback, and
  psychotherapy help to reduce a child's anxiety levels, help
  them to participate in normal activities and help the child
  to better tolerate the pain.
ο‚— They have been used with the idea that pain behaviors
  produce secondary gain (special attention, school
  avoidance, etc.) that in future reinforces the pain
  behaviors.
ο‚— A significant improvement of symptoms and fewer school
  absences in children with RAP following a short period of
  cognitive behavioral family treatment is reported.
relaxation techniques
ο‚— Older children and adolescents with functional
  abdominal pain can learn brief muscle relaxation
  techniques such as deep breathing exercises.
ο‚— These techniques should be performed for 10 minutes
  at least twice every day, and can also be used during
  times of pain.
prognosis
ο‚— Nearly half of the children with functional RAP
  experience pain as adults.
ο‚— Other studies have reported development of irritable
  bowel syndrome in 25-29% of them in later life.
Abdominal pain

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Abdominal pain

  • 1. ABDOMINAL PAIN A presentation by Dr. Ravi Malik CMD Radix Hospital IMA headquaters DMC medical education convenor Ex President IMA East Delhi Chief health news analyst
  • 2. INTRODUCTION ο‚— RAP ο‚— 3 episodes over 3 months ο‚— Severe enough ο‚— Inter periods ο‚— No specific cause identified
  • 3. epidemilogy ο‚— 10-12% of school aged children. ο‚— Peak incidence at 4-6 years and at 7-12 years. ο‚— Obesity and RAP. ο‚— Fruit consumption and RAP.
  • 4. clinical profile ο‚— Pain in genuine ο‚— Peri-umbilical pain ο‚— Nausea, vomiting ο‚— Pallor ο‚— Headache & limb pains ο‚— Family history
  • 5. classification β€’ Recurrent abd. pain can be organic or nonorganic. β€’ Nonorganic(functional) abd pain β€’ Functional dyspepsia β€’ Irritable bowel syndrome β€’ Abdominal migraine β€’ Aerophagia β€’ Functional abdominal pain.
  • 6. ο‚— Functional dyspepsia ο‚— Pain or discomfort in the upper abdomen ο‚— Stomach fullness ο‚— Bloating ο‚— Nausea ο‚— Retching or vomiting. ο‚— Irritable bowel syndrome ο‚— Abdominal migraine ο‚— Intense abdominal pain ο‚— Mid-abdomen ο‚— Anorexia, nausea, vomiting, pallor, headache, or sensitivity to light ο‚— A family history of migraine ο‚— Functional abdominal pain syndrome
  • 7. pathophysiology Gastrointestinal motility -High levels of emotional stress and abnormalities in autonomic nervous system which regulate gastrointestinal motility may contribute. Visceral hypersensitivity -The intensity of the signals from the gastrointestinal system is exaggerated. Abnormal bowel sensitivity to physiological, psychologic or noxious stimuli may be present. This may occur following illnesses that cause inflammation in the intestine (e.g. viral gastroenteritis) or after psychologically traumatic events.
  • 8. Emotional stress - Patients can sometimes date the onset of pain to a specific stressful event, such as change in school, birth of a sibling or separation of parents, family member's illess. ο‚— Higher levels of anxiety and depression are found in patients with RAP than in healthy children. ο‚— Starting school may also trigger recurrent abdominal pain. Psychological factors:- ο‚— A child can develop chronic abdominal pain related to his or her need for attention. ο‚— Parental response to child's pain can reinforce the child's behavior. If parents are worried about child's pain, the child may become more anxious, and the pain may worsen. ο‚— Parents should pay attention to the child's other activities, this might satisfy the child's need for attention & reduce the abdominal pain.
  • 9. etiology Organic Pain (10%) Non-organic Pain (90%) Site Flanks, suprapublid Central and often epigastric Family History - VE + VE Psychological History - VE + VE Headache - VE + VE Weight Loss - VE + VE Abnormal Signs - VE + VE Abnormal Investigations - VE + VE Alarming Symptoms - VE + VE
  • 10. rop (organic) ο‚— GIT ο‚— Infections – ameba, giardia, dysentry, H. pylori ο‚— Inflamatery – IBD, Hepatitis, appendicitis Dietory intolerance – lactess ο‚— Constipation ο‚— GI reflux disease ο‚— Acid peptic disease
  • 11. causes of rop (organic) Urinary tract Gynecological Miscellaneous Urinary tract Ovarian cyst infection Abdominal Urinary calculi epilepsy Endometriosis Pelvi-ureteric Physical, junction Pelvic emotional and obstruction inflammatory sexual abuse Chronic disease pancreatitis
  • 12. alarm symptoms Features that suggest an organic disorder may include one or more of the following: ο‚— Pain that awakens the child, ο‚— Significant vomiting/constipation/bloating ο‚— Persistent right upper/lower quadrant pain ο‚— Unexplained fever ο‚— Dysphagia ο‚— Chronic severe diarrhea ο‚— G.I. blood loss ο‚— Unintentional weight loss or slowed growth ο‚— Delayed puberty ο‚— Pain/ bleeding with urination ο‚— Family H/O inflammatory bowel disease, celiac or peptic ulcer disease
  • 13. alarm signs ο‚— Localized tenderness in right upper/lower quadrant ο‚— Localized fullness or mass ο‚— Hepatomegaly/Splenomegaly ο‚— Jaundice ο‚— Costovertebral angle tenderness ο‚— Arthritis ο‚— Spinal tenderness ο‚— Perianal disease ο‚— Unexplained physical findings ο‚— Pallor/Rash ο‚— Hernia
  • 14. ο‚— Absence of alarm symptoms & signs, a normal physical examination, and a normal stool hemoccult test is sufficient for an initial diagnosis of functional abdominal pain. ο‚— Identifying organic abnormalities by comprehensive investigations does not necessarily mean that the explanation for the symptoms is found. ο‚— Organic and non organic causes for RAP can co-exist in some patients.
  • 15. diagnosis ο‚— RAP should not require an exhaustive series of diagnostic tests to rule out organic causes of pain. ο‚— History – absence of alarming symptoms ο‚— Meticulous examination ο‚— Other associated symptoms ο‚— Normal investigations
  • 16. investigations in recurrent abdominal pain Basic investigations (1st line investigations) ο‚— Full blood count ο‚— ESR/C-reactive protein ο‚— Urine analysis & Urine culture ο‚— Stool for ova, cysts and parasites Second line investigations ο‚— Plain X-ray abdomen ο‚— LFT & KFT ο‚— Celiac panel ο‚— Abdominal ultrasound ο‚— Breath hydrogen test for lactose intolerance ο‚— Tests for Helicobacter pylori ο‚— Barium follow through ο‚— Esophageal manometry and pH-metry ο‚— Upper and lower gastrointestinal endoscopy ο‚— Intravenous urogram/micturition cystourethrogram
  • 17. ο‚— Only basic urine, stool and blood examinations are recommended to exclude organic causes in the diagnosis of RAP. ο‚— Ultrasound scanning, extensive radiographic evaluation and invasive investigations like endoscopy in these children are rarely diagnostic or cost effective. ο‚— Presence of an abnormal test result alone does not pinpoint to a diagnosis unless it is clinically relevant.
  • 18. abdominal pain treatment ο‚— If the initial evaluation suggests an organic disorder, the likely causes of pain will be investigated and a treatment plan will be developed. ο‚— Chronic abdominal pain in children is most often caused by a functional disorder. ο‚— There are a variety of treatments that can be helpful, but no single treatment is best. Most experts recommend trying several treatments. ο‚— This may require several visits with the doctor, especially if pain has been a problem for a long time.
  • 19. ο‚— The first goal of treatment is to help the child return to normal activities. A second goal is to improve the child's pain. ο‚— It may take some time to figure out what is causing the pain and find the best treatment. ο‚— A functional disorder does not mean that the child does not have pain or that it's "all in their head". ο‚— It is important to build a good relationship with the parents, this will allow the doctor to explore stressors, try various treatments, and continue the evaluation when necessary. ο‚— Acknowledge that the child's pain is real and offer sympathy, support, and reassurance. But also take care to avoid reinforcing the pain by giving it undue attention.
  • 20. guidelines for management of recurrent abdominal pain ο‚— Rule out organic cause ο‚— Reassurance & education of the family. ο‚— Discuss the apprehensions of family. ο‚— Explore stressors. ο‚— Acknowledge but no undue attention. ο‚— Avoid psychological labelling.
  • 21. guidelines for management of recurrent abdominal pain-(II) ο‚— Allow normal activity. ο‚— Establish regular follow-up system of return visits to monitor the symptoms. ο‚— Be available Assure parents that you are available to see the child if changes occur or the parents become anxious. ο‚— Allow appropriate time, in an unrushed environment for them. ο‚— Make judicious use of β€œsecond opinions” ο‚— With this approach, approximately 30% to 60% of children have resolution of their pain. ο‚— Remainder continue to exhibit symptoms and go on to be adults with abdominal pain, anxiety, or other somatic disorders.
  • 22. pharmacological management ο‚— Pharmacological treatments are commonly used in an effort to manage symptoms despite the lack of data supporting their efficacy. ο‚— Antispasmodics & low dose amitriptyline are used. ο‚— Famotidine (an H2-receptor antagonist) is effective in children with RAP who have predominantly dyspeptic symptoms. ο‚— Pizotifen, a serotonin antagonist, has been found to be effective when used prophylactically in children with abdominal migraine. Local remedies: Many local remedies are used to alleviate symptoms in children with RAP. Peppermint oil found to be very effective in the treatment of irritable bowel syndrome in children.
  • 23. dietary modifications ο‚— Treatment trials of fibre supplements and lactose restricting diets reveal a 50% decrease of pain episodes. ο‚— In some children, there are foods, drinks, and medicines that make symptoms worse. ο‚— Common triggers include: High-fat foods, Caffeine & foods that increase gas (beans, onions, raisins, bananas, apricots, prunes, cabbage, cauliflower, broccoli etc.) ο‚— Medicines that can cause upset stomach include aspirin and ibuprofen etc.
  • 24. behavioral therapies ο‚— Recommended for children or adolescents with functional abdominal pain that has severely impacted activities of daily living. ο‚— Cognitive-behavioral therapy, hypnosis, biofeedback, and psychotherapy help to reduce a child's anxiety levels, help them to participate in normal activities and help the child to better tolerate the pain. ο‚— They have been used with the idea that pain behaviors produce secondary gain (special attention, school avoidance, etc.) that in future reinforces the pain behaviors. ο‚— A significant improvement of symptoms and fewer school absences in children with RAP following a short period of cognitive behavioral family treatment is reported.
  • 25. relaxation techniques ο‚— Older children and adolescents with functional abdominal pain can learn brief muscle relaxation techniques such as deep breathing exercises. ο‚— These techniques should be performed for 10 minutes at least twice every day, and can also be used during times of pain.
  • 26. prognosis ο‚— Nearly half of the children with functional RAP experience pain as adults. ο‚— Other studies have reported development of irritable bowel syndrome in 25-29% of them in later life.