Global Health ResearchGlobal Health Researchprojectproject
Contents:Contents:GeographicGeographicPoliticalPoliticalInfrastructure and EconomyInfrastructure and EconomyCultural/Ethni...
GeographicGeographicWorld mapWorld mapClimate and geographic terrainClimate and geographic terrain
World mapWorld mapIsrael is at the eastern end of theIsrael is at the eastern end of theMediterranean Sea, bounded byMedit...
Climate and geographic terrainClimate and geographic terrainTemperatures in Israel vary widely, especially during theTempe...
PoliticalPoliticalSystem of governmentSystem of governmentAny recent or current civil, political unrestAny recent or curre...
System of governmentSystem of governmentIsrael is a parliamentary democracy, dividedIsrael is a parliamentary democracy, d...
Any recent or current civil, political unrest orAny recent or current civil, political unrest orwars and effects on countr...
Infrastructure and EconomyInfrastructure and EconomyMajor industriesMajor industriesLevel of personal incomeLevel of perso...
Major industriesMajor industriesIsrael has a well-developedIsrael has a well-developed chemicalchemicalindustryindustry wi...
Level of personal incomeLevel of personal incomeBasisBasis - Israeli residents are taxed on their worldwide income,- Israe...
Level of developmentLevel of developmentTap water is safe and drinkable in Israel, except at The Dead Sea.Tap water is saf...
Level of developmentLevel of developmentEducation in IsraelEducation in Israel refers to the comprehensive education syste...
Cultural/EthnicCultural/EthnicMain ethnic groups within countryMain ethnic groups within countryMajor religion of country ...
Main ethnic groups within countryMain ethnic groups within countryJewish 76.4% (of which Israel-bornJewish 76.4% (of which...
Major religion of country and their beliefsMajor religion of country and their beliefs(any ritual, ideas or practices that...
WhatWhat JewsJews BelieveBelieveJews believe that one person cannot die for the sins of another.Jews believe that one pers...
CultureCultureIsraeli literatureIsraeli literature is primarily poetry and prose written in Hebrew, asis primarily poetry ...
Healthcare systemHealthcare systemLevel of development and structure ofLevel of development and structure ofhealth care de...
Level of development and structureLevel of development and structureof health care delivery systemsof health care delivery...
Safety and qualitySafety and qualityIsrael has one of the most technologically advanced and highest-Israel has one of the ...
Health care providersHealth care providersProviders in the Israeli healthcare system consist of aProviders in the Israeli ...
DoctorsDoctorsIn 2010, there were 25,542 doctors inIn 2010, there were 25,542 doctors inIsrael - 3.36 doctors for every 1,...
Emergency servicesEmergency servicesEmergency medical services in Israel are provided byEmergency medical services in Isra...
CANCER RANK BY TYPECANCER RANK BY TYPE05101520253011 Breast Cancer2 Lung Cancers3 Colon-Rectum Cancers4 Pancreas Cancer5 L...
ISRAEL TOTAL DEATHS BY CAUSEISRAEL TOTAL DEATHS BY CAUSENUMBER OF DEATHSNUMBER OF DEATHS05001,0001,5002,0002,5003,0003,500...
ISRAEL TOTAL DEATHS BY CAUSEISRAEL TOTAL DEATHS BY CAUSEPERCENTAGEPERCENTAGE0246810121416181 2 3 4 5 6 7 8 9 10CAUSEPercen...
Compare summaryCompare summaryDiabetes:Diabetes: In High-income counties percentage of diabetes deathsis 2.6%, in Israel i...
Smoking StatisticsSmoking Statistics6000 people6000 people die each year in Israel from cigarettes, thats aboutdie each ye...
Top 10 causes of death inTop 10 causes of death inHigh-income countriesHigh-income countries(average statistics)(average s...
MEN IncidenceMEN Incidence020004000600080001000012000Prostate(18.6%)Colorectum(15.7%)Lung (10.8) Other(54.9%)Incidence (nu...
MEN MortalityMEN Mortality020040060080010001200140016001800Prostate(7.9%)Colorectum(13.5%)Lung(21.1%)Others(57.5%)Mortalit...
Women IncidenceWomen Incidence010002000300040005000600070008000Breast (31.8%) Colorectum(14.9%)Lung (6.1%) Others (47.2%)I...
Women MortalityWomen Mortality0500100015002000250030003500Breast (18.5%) Colorectum(12.8%)Lung (9.8%) Others (58.9%)Incide...
MENMENIsrael vs. USAIsrael vs. USA
WomenWomenIsrael vs. USAIsrael vs. USA
Pancreatic Cancer in IsraelStatistics, rankStatistics, rankSymptomsSymptomsRisk factorRisk factorEarly detection, screenin...
Statistics, rankStatistics, rankCancerIncidence Mortality 5-year prevalenceNumber (%) ASR (W) Number (%) ASR (W) Number (%...
SymtomsSymtomsCBDMPDMaPMiP(it hidden)MiPMiP-Minor Papilla;-Minor Papilla; MaPMaP-Major Papilla;-Major Papilla; MPDMPD-Majo...
SymptomsSymptomsPancreatic cancer does not cause symptoms in itsearliest stages. By the time symptoms are noted, theBy the...
SymptomsSymptomsPainPain - About 95% of all patients with pancreatic cancer have pain- About 95% of all patients with panc...
Risk factorsRisk factorsEpidemiological studies have identifiedenvironmental and familial risk factors for thedisease:male...
high consumption of fried/grilled/processed meatschronic pancreatitisGenetic risk factors are believed responsible for 5–1...
ScreeningScreeningThere are no sensitive non-evasive screeningmodalities or early diagnostic tests. Theseinclude:Blood tes...
PreventionPreventionPreventive advice on lifestyle habits will be given topatients and family members at risk for pancreat...
Treatment and futureTreatment and futureA clinical trial withA clinical trial with TL-118TL-118--a new treatment for--a ne...
TL-118TL-118 was initially tested in a mouse model ofwas initially tested in a mouse model ofpancreatic cancer. In these p...
http://www.slideshare.net/lyubachka121/jewish-religious-beliefs-and-practhttp://www.slideshare.net/lyubachka121/jewish-rel...
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    1. 1. Global Health ResearchGlobal Health Researchprojectproject
    2. 2. Contents:Contents:GeographicGeographicPoliticalPoliticalInfrastructure and EconomyInfrastructure and EconomyCultural/EthnicCultural/EthnicHealthcare systemHealthcare systemStatisticsStatistics
    3. 3. GeographicGeographicWorld mapWorld mapClimate and geographic terrainClimate and geographic terrain
    4. 4. World mapWorld mapIsrael is at the eastern end of theIsrael is at the eastern end of theMediterranean Sea, bounded byMediterranean Sea, bounded byLebanon to the north, Syria to theLebanon to the north, Syria to thenortheast, Jordan to the east, andnortheast, Jordan to the east, andEgypt to the southwest. It liesEgypt to the southwest. It liesbetween latitudes 29° and 34° N,between latitudes 29° and 34° N,and longitudes 34° and 36° E.and longitudes 34° and 36° E.
    5. 5. Climate and geographic terrainClimate and geographic terrainTemperatures in Israel vary widely, especially during theTemperatures in Israel vary widely, especially during thewinter. The more mountainous regions can be windy, cold,winter. The more mountainous regions can be windy, cold,and sometimes snowyand sometimes snowyMeanwhile, coastal cities, such as Tel Aviv and Haifa, haveMeanwhile, coastal cities, such as Tel Aviv and Haifa, havea typical Mediterranean climate with cool, rainy winters anda typical Mediterranean climate with cool, rainy winters andlong, hot summers.long, hot summers.The area of Beersheba and the Northern Negev has aThe area of Beersheba and the Northern Negev has asemi-arid climate with hot summers, cool winters and fewersemi-arid climate with hot summers, cool winters and fewerrainy days than the Mediterranean climate.rainy days than the Mediterranean climate.The Southern Negev and the Arava areas have desertThe Southern Negev and the Arava areas have desertclimate with very hot and dry summers, and mild wintersclimate with very hot and dry summers, and mild winterswith few days of rain.with few days of rain.The highest temperature in the continent of Asia (53.7The highest temperature in the continent of Asia (53.7°C/128.7 °F) was recorded in 1942 at Tirat Zvi kibbutz in°C/128.7 °F) was recorded in 1942 at Tirat Zvi kibbutz inthe northern Jordan river valley. From May to September,the northern Jordan river valley. From May to September,rain in Israel is rare.rain in Israel is rare.January is the coldest month, with temperatures from 5 CJanuary is the coldest month, with temperatures from 5 Cto 10 C, and August is the hottest month at 18 C to 38 C.to 10 C, and August is the hottest month at 18 C to 38 C.
    6. 6. PoliticalPoliticalSystem of governmentSystem of governmentAny recent or current civil, political unrestAny recent or current civil, political unrestor wars and effects on countryor wars and effects on country
    7. 7. System of governmentSystem of governmentIsrael is a parliamentary democracy, dividedIsrael is a parliamentary democracy, dividedinto six administrative districts.into six administrative districts.There is no formal constitution; instead, there isThere is no formal constitution; instead, there isthe Declaration of Establishment, from 1948,the Declaration of Establishment, from 1948,the Basic Laws of the parliament (the Basic Laws of the parliament ( KnessetKnesset ),),and the Israel citizenship law.and the Israel citizenship law.The head of government is the prime minister,The head of government is the prime minister,elected by popular vote for a four-year term.elected by popular vote for a four-year term.Executive power is exercised by theExecutive power is exercised by thegovernment.government.The 120 members of the Knesset also areThe 120 members of the Knesset also areelected for four years. The Knesset selects theelected for four years. The Knesset selects thepresident, who serves as chief of state.president, who serves as chief of state.The political system of the State of Israel and itsThe political system of the State of Israel and itsmain principles are set out in 11 Basic Laws.main principles are set out in 11 Basic Laws.
    8. 8. Any recent or current civil, political unrest orAny recent or current civil, political unrest orwars and effects on countrywars and effects on countryThe Israeli–Palestinian conflictThe Israeli–Palestinian conflict isisthe ongoing struggle between Israelisthe ongoing struggle between Israelisand Palestinians that began in theand Palestinians that began in theearly 20th century.early 20th century.Arab–Israeli conflictArab–Israeli conflict refers to therefers to thepolitical tension and military conflictspolitical tension and military conflictsbetween the Arab League and Israelbetween the Arab League and Israeland between Arabs and Israelis. Theand between Arabs and Israelis. Theroots of the modern Arab–Israeliroots of the modern Arab–Israeliconflict lie in the rise of Zionism andconflict lie in the rise of Zionism andArab nationalism towards the end ofArab nationalism towards the end ofthe 19th century.the 19th century.Iran–Israel relationsIran–Israel relations:: Iran may launchIran may launchpre-emptive strike on Israel, conflictpre-emptive strike on Israel, conflictcould grow into WWIIIcould grow into WWIIIGreen color shows countries, that are in Arab leagueGreen color shows countries, that are in Arab leagueYitzhakYitzhak RabinRabin and Yasser Arafatand Yasser Arafatshake hands at the signing ofshake hands at the signing ofthe Oslo Accords, with Billthe Oslo Accords, with BillClintonClinton behind them, 1993them, 1993
    9. 9. Infrastructure and EconomyInfrastructure and EconomyMajor industriesMajor industriesLevel of personal incomeLevel of personal incomeLevel of development:Level of development:1. Safe Food and Water availability1. Safe Food and Water availability2. Water/Sewer/Waste management system2. Water/Sewer/Waste management system3. Transportation and communication system3. Transportation and communication system4. Education system4. Education system5. protection system5. protection system
    10. 10. Major industriesMajor industriesIsrael has a well-developedIsrael has a well-developed chemicalchemicalindustryindustry with many of its products aimed atwith many of its products aimed atthe export market.the export market.The Dead Sea Works in Sdom is the worldsThe Dead Sea Works in Sdom is the worldsfourth largest producer and supplier offourth largest producer and supplier ofpotashpotash products.products.Israel is one of the worlds three majorIsrael is one of the worlds three majorcenters for polishedcenters for polished diamondsdiamonds..During the past two decades IsraelsDuring the past two decades Israelsindustrial sector has made a major shift toindustrial sector has made a major shift tothe areas ofthe areas of medical electronicsmedical electronics,, agro-agro-technologytechnology,, telecommunicationstelecommunications,,computercomputer hardwarehardware andand softwaresoftware..
    11. 11. Level of personal incomeLevel of personal incomeBasisBasis - Israeli residents are taxed on their worldwide income,- Israeli residents are taxed on their worldwide income,while non-residents are taxed only on their Israeli sourcedwhile non-residents are taxed only on their Israeli sourcedincome.income.Taxable IncomeTaxable Income - All income from employment and business- All income from employment and businessis taxable. Passive income from bank deposits and savings,is taxable. Passive income from bank deposits and savings,both in Israel and abroad are also taxable.both in Israel and abroad are also taxable.Capital GainsCapital Gains - Capital gains may arise on the sale of assets;- Capital gains may arise on the sale of assets;for individuals this is generally 25%.for individuals this is generally 25%.
    12. 12. Level of developmentLevel of developmentTap water is safe and drinkable in Israel, except at The Dead Sea.Tap water is safe and drinkable in Israel, except at The Dead Sea.Jews are bound by a set of dietary laws calledJews are bound by a set of dietary laws called kashrutkashrut , which,, which,among other restrictions, forbid the consumption ofamong other restrictions, forbid the consumption of pork andpork andshellfishshellfish, as well as the consumption of both meat and milk products, as well as the consumption of both meat and milk productsat the same meal. Not all Israelis observe these rules, but manyat the same meal. Not all Israelis observe these rules, but manyrestaurants do.restaurants do.The system, called Meitavit, is an end-to-endThe system, called Meitavit, is an end-to-end water and sewagewater and sewageservices management systemservices management system. Meitavit includes various SAP-based. Meitavit includes various SAP-basedcomponents including financial, logistics, procurement, inventory,components including financial, logistics, procurement, inventory,control, billing and collections, customer relationship managementcontrol, billing and collections, customer relationship management(CRM), project management and human resources.(CRM), project management and human resources.Transportation in IsraelTransportation in Israel is based mainly on private motor vehicles and busis based mainly on private motor vehicles and busservice and an expanding railway network. Demands of population growth,service and an expanding railway network. Demands of population growth,political factors, the Israel Defense Forces, tourism and increased traffic setpolitical factors, the Israel Defense Forces, tourism and increased traffic setthe pace. All facets of transportation in Israel are under the supervision ofthe pace. All facets of transportation in Israel are under the supervision ofthe Ministry of Transport and Road Safety.the Ministry of Transport and Road Safety.The Communications systemThe Communications system in Israelin Israel is the most developed in theis the most developed in theMiddle East, although it is not the biggest. Israels system consists ofMiddle East, although it is not the biggest. Israels system consists ofCoaxial cables, Optical fibers, and Microwave radio relay.Coaxial cables, Optical fibers, and Microwave radio relay.
    13. 13. Level of developmentLevel of developmentEducation in IsraelEducation in Israel refers to the comprehensive education system of Israel. Expenditurerefers to the comprehensive education system of Israel. Expenditureon education accounts for approximately 10% of GDP, and most schools are subsidizedon education accounts for approximately 10% of GDP, and most schools are subsidizedby the state. The education system consists of three tiers: primary education (grades 1-6,by the state. The education system consists of three tiers: primary education (grades 1-6,approx. ages 6–12), middle school (grades 7-9, approx. ages 12–15) and high schoolapprox. ages 6–12), middle school (grades 7-9, approx. ages 12–15) and high school(grades 10-12, approx. ages 15–18).(grades 10-12, approx. ages 15–18). In 2012, Israel was named the second mostIn 2012, Israel was named the second mosteducated country in the world according to the Organization for Economic Cooperationeducated country in the world according to the Organization for Economic Cooperationand Developments Education at a Glance report.and Developments Education at a Glance report.Protection systemProtection system Based on its latestBased on its latestcombat experiences, the Israel Defensecombat experiences, the Israel DefenseForces (IDF) is moving forward with theForces (IDF) is moving forward with thedevelopment and fielding of activedevelopment and fielding of activeprotection systems (APS) for tanks andprotection systems (APS) for tanks andarmored infantry fighting vehicles (AIFV).armored infantry fighting vehicles (AIFV).
    14. 14. Cultural/EthnicCultural/EthnicMain ethnic groups within countryMain ethnic groups within countryMajor religion of country and their beliefsMajor religion of country and their beliefs(any ritual, ideas or practices that may influence health)(any ritual, ideas or practices that may influence health)CultureCulture
    15. 15. Main ethnic groups within countryMain ethnic groups within countryJewish 76.4% (of which Israel-bornJewish 76.4% (of which Israel-born67.1%, Europe/America-born 22.6%67.1%, Europe/America-born 22.6%Africa-born 5.9%, Asia-born 4.2%)Africa-born 5.9%, Asia-born 4.2%)non-Jewish 23.6% (mostly Arab) (datanon-Jewish 23.6% (mostly Arab) (datafrom 2004)from 2004)
    16. 16. Major religion of country and their beliefsMajor religion of country and their beliefs(any ritual, ideas or practices that may influence health)(any ritual, ideas or practices that may influence health)Religion in IsraelReligion in Israel is a central feature of the country and plays ais a central feature of the country and plays amajor role in shaping Israeli culture and lifestyle, and religion hasmajor role in shaping Israeli culture and lifestyle, and religion hasplayed a central role in Israels history.played a central role in Israels history.Israel has no entrenched constitution, but freedom of religion isIsrael has no entrenched constitution, but freedom of religion isanchored in law.anchored in law.Most citizens in the State of Israel are Jewish, and most Israeli JewsMost citizens in the State of Israel are Jewish, and most Israeli Jewspractice Judaism in some form. In the last two centuries the largestpractice Judaism in some form. In the last two centuries the largestJewish community in the world, in the United States, has dividedJewish community in the world, in the United States, has dividedinto a number of Jewish denominations.into a number of Jewish denominations.The largest and most influential of these denominations areThe largest and most influential of these denominations areOrthodox Judaism, Reform Judaism, and Conservative Judaism. AllOrthodox Judaism, Reform Judaism, and Conservative Judaism. Allof the above denominations exist, to varying degrees, in the State ofof the above denominations exist, to varying degrees, in the State ofIsrael. Nevertheless, Israelis tend to classify Jewish identity in waysIsrael. Nevertheless, Israelis tend to classify Jewish identity in waysthat are strikingly different from American Jewry.that are strikingly different from American Jewry.
    17. 17. WhatWhat JewsJews BelieveBelieveJews believe that one person cannot die for the sins of another.Jews believe that one person cannot die for the sins of another.We do not need a blood sacrifice for the forgiveness of sins.We do not need a blood sacrifice for the forgiveness of sins.Jews believe that Jesus was not the messiah.Jews believe that Jesus was not the messiah.Jews believe that God hates human sacrifices.Jews believe that God hates human sacrifices.Jews believe that one is born into the world with original purity.Jews believe that one is born into the world with original purity.Jews do not believe in original sin.Jews do not believe in original sin.Jews believe that God is one and indivisible.Jews believe that God is one and indivisible.Jews do not believe in a trinity.Jews do not believe in a trinity.Jews believe in The Satan, but not in a devil.Jews believe in The Satan, but not in a devil.There is a difference between The Satan and the devil.There is a difference between The Satan and the devil.Jews believe that God is God, and humans are humans.Jews believe that God is God, and humans are humans.God does not become human nor do humans become God.God does not become human nor do humans become God.Jews believe that "Jews for Jesus," "Messianic Jews," and "HebrewJews believe that "Jews for Jesus," "Messianic Jews," and "HebrewChristians" are no longer Jews, even if they were once Jews.Christians" are no longer Jews, even if they were once Jews.The "Jewish roots" of Christianity?The "Jewish roots" of Christianity?
    18. 18. CultureCultureIsraeli literatureIsraeli literature is primarily poetry and prose written in Hebrew, asis primarily poetry and prose written in Hebrew, aspart of the renaissance of Hebrew as a spoken language since thepart of the renaissance of Hebrew as a spoken language since themid-19th century, although a small body of literature is published inmid-19th century, although a small body of literature is published inother languages, such as English.other languages, such as English.Israeli musicIsraeli music contains musical influences from all over the world;contains musical influences from all over the world;Sephardic music, Hasidic melodies, Belly dancing music, GreekSephardic music, Hasidic melodies, Belly dancing music, Greekmusic, jazz, and pop rock are all part of the music scene.music, jazz, and pop rock are all part of the music scene.Ten IsraeliTen Israeli filmsfilms have been final nominees for Best Foreignhave been final nominees for Best ForeignLanguage Film at the Academy Awards since the establishment ofLanguage Film at the Academy Awards since the establishment ofIsrael. The 2009 movieIsrael. The 2009 movie AjamiAjami was the third consecutive nominationwas the third consecutive nominationof an Israeli film.of an Israeli film.Israeli cuisineIsraeli cuisine includes local dishes as well as dishes brought toincludes local dishes as well as dishes brought tothe country by Jewish immigrants from around the world. Since thethe country by Jewish immigrants from around the world. Since theestablishment of the State in 1948, and particularly since the lateestablishment of the State in 1948, and particularly since the late1970s, an Israeli fusion cuisine has developed.1970s, an Israeli fusion cuisine has developed.
    19. 19. Healthcare systemHealthcare systemLevel of development and structure ofLevel of development and structure ofhealth care delivery systemshealth care delivery systemsSafety and qualitySafety and qualityHealth care providersHealth care providersDoctorsDoctorsEmergency servicesEmergency services
    20. 20. Level of development and structureLevel of development and structureof health care delivery systemsof health care delivery systemsHealth care in IsraelHealth care in Israel is universal and participation in ais universal and participation in amedical insurance plan is compulsory.medical insurance plan is compulsory.Health careHealth care coverage is administered by a small numbercoverage is administered by a small numberof organizations, with funding from the government.of organizations, with funding from the government.Generally,Generally, health carehealth care in Israel is of high-quality and isin Israel is of high-quality and isdelivered in an efficient and effective manner. Partly as adelivered in an efficient and effective manner. Partly as aresult of this, at an overall 82 years, Israelis enjoy theresult of this, at an overall 82 years, Israelis enjoy thefourth-longest life expectancy in the world as of 2012.fourth-longest life expectancy in the world as of 2012.
    21. 21. Safety and qualitySafety and qualityIsrael has one of the most technologically advanced and highest-Israel has one of the most technologically advanced and highest-quality healthcare systems in the world.quality healthcare systems in the world.Hospitals in Israel are equipped with modern facilities and high-Hospitals in Israel are equipped with modern facilities and high-quality medical technologyquality medical technologyMedical staff are trained from four to six years in one of theMedical staff are trained from four to six years in one of thecountrys five university medical schools.countrys five university medical schools.The country is a world leader in advanced infrastructure of medicalThe country is a world leader in advanced infrastructure of medicaland paramedical researchand paramedical research
    22. 22. Health care providersHealth care providersProviders in the Israeli healthcare system consist of aProviders in the Israeli healthcare system consist of amixture of private, semi-private and public entitiesmixture of private, semi-private and public entitiesGenerally, family and primary medicine facilities are runGenerally, family and primary medicine facilities are rundirectly by Clalit Health Care Services for its membersdirectly by Clalit Health Care Services for its memberswhile the other HMOs operate their own family practicewhile the other HMOs operate their own family practiceclinics in the larger cities and contract with privatelyclinics in the larger cities and contract with privatelyoperated family practice clinics in smaller communities.operated family practice clinics in smaller communities.
    23. 23. DoctorsDoctorsIn 2010, there were 25,542 doctors inIn 2010, there were 25,542 doctors inIsrael - 3.36 doctors for every 1,000Israel - 3.36 doctors for every 1,000people. This ratio is one of the highest ofpeople. This ratio is one of the highest ofall industrialized countries.all industrialized countries.
    24. 24. Emergency servicesEmergency servicesEmergency medical services in Israel are provided byEmergency medical services in Israel are provided bythe Magen David Adom (MDA) organization, which staffsthe Magen David Adom (MDA) organization, which staffsapproximately 1,200emergency medicalapproximately 1,200emergency medicaltechnicians, paramedics, and emergency physicians,technicians, paramedics, and emergency physicians,and 10,000 volunteers.and 10,000 volunteers.The organizations operates 95 stations and a fleet ofThe organizations operates 95 stations and a fleet ofover 700 ambulances.over 700 ambulances.The majority of the fleet consists of Basic Life SupportThe majority of the fleet consists of Basic Life Support(is the level of medical care which is used for victims of(is the level of medical care which is used for victims oflife-threatening illnesses or injuries until the victims canlife-threatening illnesses or injuries until the victims canbe given full medical care at a hospital. ) ambulances.be given full medical care at a hospital. ) ambulances.
    25. 25. CANCER RANK BY TYPECANCER RANK BY TYPE05101520253011 Breast Cancer2 Lung Cancers3 Colon-Rectum Cancers4 Pancreas Cancer5 Lymphomas6 Stomach Cancer7 Leukemia8 Prostate Cancer9 Skin Cancers10 Ovary Cancer
    26. 26. ISRAEL TOTAL DEATHS BY CAUSEISRAEL TOTAL DEATHS BY CAUSENUMBER OF DEATHSNUMBER OF DEATHS05001,0001,5002,0002,5003,0003,5004,0004,5005,00011 Coronary Heart Disease2 Diabetes Mellitus3 Stroke4 Lung Cancers5 Colon-Rectum Cancers6 Kidney Disease7 Breast Cancer8 Alzheimers/Dementia9 Influenza & Pneumonia10 Lung Disease
    27. 27. ISRAEL TOTAL DEATHS BY CAUSEISRAEL TOTAL DEATHS BY CAUSEPERCENTAGEPERCENTAGE0246810121416181 2 3 4 5 6 7 8 9 10CAUSEPercentage1 Coronary Heart Disease2 Diabetes Mellitus3 Stroke4 Lung Cancers5 Colon-Rectum Cancers6 Kidney Disease7 Breast Cancer8 Alzheimers/Dementia9 Influenza & Pneumonia10 Lung Disease
    28. 28. Compare summaryCompare summaryDiabetes:Diabetes: In High-income counties percentage of diabetes deathsis 2.6%, in Israel it’s 8.42% (3,2 times higher). Israel is a high-income country and this statistics shows, that people of Israel canhave a genetic predisposition for this disease.Kidney:Kidney: Israel has kidney’s diseases on 6-th place, althoughaverage statistic of High-income countries doesn’t include thisdisease in top 10. It may mean, that not all water is good for drink orother diseases can occur kidney illness.Colon and rectal cancersColon and rectal cancers:: there are different causes: geneticsthere are different causes: genetics(less then 5-15% of all causes), older age, male gender, high intake(less then 5-15% of all causes), older age, male gender, high intakeof fat, alcohol or red meat, obesity, smoking and a lack of physicalof fat, alcohol or red meat, obesity, smoking and a lack of physicalexercise. In Israel these diseases are higher then in averageexercise. In Israel these diseases are higher then in averagestatistics.statistics.Breast cancer:Breast cancer: in Israel this disease 2.2 times higher then in avgstat-s. The main cause may be genetics.
    29. 29. Smoking StatisticsSmoking Statistics6000 people6000 people die each year in Israel from cigarettes, thats aboutdie each year in Israel from cigarettes, thats about 1616people a day!people a day!28%28% of Israel populationof Israel population are smokers. In 1973 smokers wereare smokers. In 1973 smokers were 42%42%of the population.of the population.Although the decrease in the amount of smokers, the starting age ofAlthough the decrease in the amount of smokers, the starting age ofthe smokers is decreasing. Today eventhe smokers is decreasing. Today even 11 years old11 years old start to smoke.start to smoke.4.5%4.5% of theof the boysboys andand 1%1% of theof the girlsgirls agedaged 11-1211-12 claim to be regularclaim to be regularsmokers.smokers.9.5%9.5% of theof the boysboys andand 6.4%6.4% of theof the girlsgirls agedaged 14-1514-15 claim to beclaim to beregular smokers.regular smokers.16%16% of theof the boysboys and 9% of theand 9% of the girlsgirls aged 16-17 claim to be regularaged 16-17 claim to be regularsmokers.smokers.90% of all smokers90% of all smokers starts smoking before they are 18.starts smoking before they are 18.90% of the Israelis90% of the Israelis support No-Smoking areas in work places.support No-Smoking areas in work places.
    30. 30. Top 10 causes of death inTop 10 causes of death inHigh-income countriesHigh-income countries(average statistics)(average statistics)00.080.160.240.320.40.480.560.640.720.80.880.961.041.121.21.281.361.441.52Deaths in millions % of deathsIschaemic heart diseaseStroke and other cerebrovascular diseaseTrachea, bronchus, lung cancersAlzheimer and other dementiasLower respiratory infectionsChronic obstructive pulmonary diseaseColon and rectum cancersDiabetes mellitusHypertensive heart diseaseBreast cancer
    31. 31. MEN IncidenceMEN Incidence020004000600080001000012000Prostate(18.6%)Colorectum(15.7%)Lung (10.8) Other(54.9%)Incidence (number)Incidence (number)Cancer Incidence (number)Prostate (18.6%) 2326Colorectum (15.7%) 1965Lung (10.8) 1345Other (54.9%) 10265
    32. 32. MEN MortalityMEN Mortality020040060080010001200140016001800Prostate(7.9%)Colorectum(13.5%)Lung(21.1%)Others(57.5%)Mortality (number)Mortality (number)Cancer Mortality (number)Prostate (7.9%) 415Colorectum (13.5%) 711Lung (21.1%) 1110Others (57.5%) 1619
    33. 33. Women IncidenceWomen Incidence010002000300040005000600070008000Breast (31.8%) Colorectum(14.9%)Lung (6.1%) Others (47.2%)Incidence (number)Incidence (number)Cancer Incidence (number)Breast (31.8%) 4203Colorectum (14.9%) 1963Lung (6.1%) 807Others (47.2%) 7863
    34. 34. Women MortalityWomen Mortality0500100015002000250030003500Breast (18.5%) Colorectum(12.8%)Lung (9.8%) Others (58.9%)Incidence (number)Incidence (number)Cancer Incidence (number)Breast (18.5%) 968Colorectum (12.8%) 672Lung (9.8%) 511Others (58.9%) 3083
    35. 35. MENMENIsrael vs. USAIsrael vs. USA
    36. 36. WomenWomenIsrael vs. USAIsrael vs. USA
    37. 37. Pancreatic Cancer in IsraelStatistics, rankStatistics, rankSymptomsSymptomsRisk factorRisk factorEarly detection, screening and preventionEarly detection, screening and preventionTreatment and futureTreatment and future
    38. 38. Statistics, rankStatistics, rankCancerIncidence Mortality 5-year prevalenceNumber (%) ASR (W) Number (%) ASR (W) Number (%) Prop.Pancreas 487 3.9 11.7 443 8.5 10.2 362 1.1 14.6Pancreatic cancer is not a common malignancy in Israel,but it is the third most common cause of cancer mortalityIn contrast, it ranks 6th in the United States and 13thworldwide. But pancreatic cancer ranks third in cancermortality in Israel, fourth in the U.S. and eighth worldwide.Incidence rates and trends 1980–2006 The incidence rateswere significantly higher in European-born Jews of both genders andin both the European and non-European-born males. Among Jewishmale immigrants who arrived after 1990, the incidence isinsignificantly higher than among other Israelis
    39. 39. SymtomsSymtomsCBDMPDMaPMiP(it hidden)MiPMiP-Minor Papilla;-Minor Papilla; MaPMaP-Major Papilla;-Major Papilla; MPDMPD-Major Pancreas Duct;-Major Pancreas Duct; CBDCBD-Common Bile Duct-Common Bile Duct
    40. 40. SymptomsSymptomsPancreatic cancer does not cause symptoms in itsearliest stages. By the time symptoms are noted, theBy the time symptoms are noted, thedisease has already been growing for some time.disease has already been growing for some time.Initial symptoms of pancreatic cancer tend to be ratherInitial symptoms of pancreatic cancer tend to be rathervague, so patients often ignore them for a certain lengthvague, so patients often ignore them for a certain lengthof time.of time.Decreased appetiteDecreased appetite - Most patients experience a greatly decreased- Most patients experience a greatly decreasedappetite (This may be one of the first symptoms of pancreaticappetite (This may be one of the first symptoms of pancreaticcancer).cancer).Unintended weight lossUnintended weight loss - Over time, up to 100% of patients with- Over time, up to 100% of patients withpancreatic cancer tend to fall about 10% below their ideal bodypancreatic cancer tend to fall about 10% below their ideal bodyweight.weight.
    41. 41. SymptomsSymptomsPainPain - About 95% of all patients with pancreatic cancer have pain- About 95% of all patients with pancreatic cancer have painJaundiceJaundice - Jaundice consists of a yellow discoloration of the skin,- Jaundice consists of a yellow discoloration of the skin,mucus membranes (tissue including that which lines the mouth),mucus membranes (tissue including that which lines the mouth),and whites of the eyes.and whites of the eyes. (When pancreatic cancer strikes the head of the(When pancreatic cancer strikes the head of thepancreas, jaundice may occur earlier in the disease because the tumor putspancreas, jaundice may occur earlier in the disease because the tumor putspressure on the common bile duct, the tube that connects the pancreas,pressure on the common bile duct, the tube that connects the pancreas,liver, and gallbladder to the intestine. When the cancer is located in theliver, and gallbladder to the intestine. When the cancer is located in thebody or tail of the pancreas, however, jaundice may occur later in thebody or tail of the pancreas, however, jaundice may occur later in thecourse of the disease)course of the disease)Nausea and vomitingNausea and vomiting - About 30% of patients with pancreatic cancer- About 30% of patients with pancreatic cancerexperience nausea and vomiting.experience nausea and vomiting.Dark urine, light-colored stoolDark urine, light-colored stool – Reasons like with jaundice– Reasons like with jaundiceaforesaidaforesaidDepression, mood swingsDepression, mood swings - Depression and mood swings occur in- Depression and mood swings occur innearly 30% of patients.nearly 30% of patients.Itching generalizedItching generalized - Itching, which is difficult to treat, is a common- Itching, which is difficult to treat, is a commonsymptom in patients.symptom in patients.
    42. 42. Risk factorsRisk factorsEpidemiological studies have identifiedenvironmental and familial risk factors for thedisease:male genderagingobesitydiabetes (type 2 or hyperglycemia occurring as aparaneoplastic phenomenon)tobacco smoking
    43. 43. high consumption of fried/grilled/processed meatschronic pancreatitisGenetic risk factors are believed responsible for 5–10% of pancreatic cancer cases They include bothgenetic disorders where pancreatic involvement isnot the usual target organ and also pancreas-specific genetic mutations causing cancerRisk factorsRisk factors
    44. 44. ScreeningScreeningThere are no sensitive non-evasive screeningmodalities or early diagnostic tests. Theseinclude:Blood testsStandard and high resolution pancreas-dedicatedabdominal computed tomographyUltrasonographyAdvanced imaging techniques using magneticresonance might be useful but are not readilyavailable in Israel.
    45. 45. PreventionPreventionPreventive advice on lifestyle habits will be given topatients and family members at risk for pancreaticcancerThe meeting in August 2009, called by the PancreasSubcommittee of the Israel Gastroenterology Societydecided that EUS (endoscopic ultrasound sonography)would be their standard test for pancreatic cancerThey adopted the following standard protocol as used inan American multicenter study for examination,documentation and follow-up of these lesions and/orpatients at high risk for the disease. Similar protocols areused in Europe.
    46. 46. Treatment and futureTreatment and futureA clinical trial withA clinical trial with TL-118TL-118--a new treatment for--a new treatment formetastatic pancreatic cancer--that has been ongoing atmetastatic pancreatic cancer--that has been ongoing atthe Hadassah University Medical Center and three otherthe Hadassah University Medical Center and three otheroncology centers in Israel, has been expanded to theoncology centers in Israel, has been expanded to theUnited States.United States.TL-118TL-118. produced by Tiltan Pharma Ltd., belongs to the. produced by Tiltan Pharma Ltd., belongs to thefamily of angiogenesis-inhibiting drugs, which means itfamily of angiogenesis-inhibiting drugs, which means itinhibits new blood vessel formation in tumors and thusinhibits new blood vessel formation in tumors and thuscuts off their blood supply and growth.cuts off their blood supply and growth.AngiogenesisAngiogenesis, the process by which new blood vessels, the process by which new blood vesselsare formed, is a hallmark capability of cancer cells. Anti-are formed, is a hallmark capability of cancer cells. Anti-angiogenic therapy has, therefore, emerged as a mostangiogenic therapy has, therefore, emerged as a mostpromising strategy with solid tumors, which rely onpromising strategy with solid tumors, which rely onaggressive angiogenesis for their growth.aggressive angiogenesis for their growth.
    47. 47. TL-118TL-118 was initially tested in a mouse model ofwas initially tested in a mouse model ofpancreatic cancer. In these pre-clinical studies,pancreatic cancer. In these pre-clinical studies, TL-118TL-118monotherapy inhibited tumor growth significantly, asmonotherapy inhibited tumor growth significantly, ascompared to the standard-of-care chemotherapy.compared to the standard-of-care chemotherapy.Moreover, whenMoreover, when TL-118TL-118 therapy was combined withtherapy was combined withstandard-of-care chemotherapy, the tumors werestandard-of-care chemotherapy, the tumors wereeliminated in all the treated animals.eliminated in all the treated animals.To date, over 100 cancer patients have been treatedTo date, over 100 cancer patients have been treatedwithwith TL-118TL-118 for up to four years, according to Tiltanfor up to four years, according to TiltanPharma, jointly owned by Yissum, the HebrewPharma, jointly owned by Yissum, the HebrewUniversitys Technology Transfer Company, and otherUniversitys Technology Transfer Company, and otherinvestors from Israel and Canada.investors from Israel and Canada.
    48. 48. http://www.slideshare.net/lyubachka121/jewish-religious-beliefs-and-practhttp://www.slideshare.net/lyubachka121/jewish-religious-beliefs-and-practhttp://www.mongabay.com/history/israel/israel-the_economy.htmlhttp://www.mongabay.com/history/israel/israel-the_economy.htmlhttp://www.worldlifeexpectancy.comhttp://www.worldlifeexpectancy.comhttp://www.pas-online.org/stats.htmlhttp://www.pas-online.org/stats.htmlhttp://globocan.iarc.fr/http://globocan.iarc.fr/http://www.haaretz.com/print-edition/news/israeli-researchers-http://www.haaretz.com/print-edition/news/israeli-researchers-identify-protein-that-may-slow-down-pancreatic-cancer-1.372930identify-protein-that-may-slow-down-pancreatic-cancer-1.372930http://www.bidmc.org/YourHealth/ConditionsAZ/KneeSprain.aspx?http://www.bidmc.org/YourHealth/ConditionsAZ/KneeSprain.aspx?ChunkID=32772ChunkID=32772http://www.hadassah.org/site/apps/nlnet/content2.aspx?http://www.hadassah.org/site/apps/nlnet/content2.aspx?c=keJNIWOvElH&b=7730783&ct=12524079&notoc=1c=keJNIWOvElH&b=7730783&ct=12524079&notoc=1http://www.cancer.gov/http://www.cancer.gov/
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