Critical appraisal of http://www.ncbi.nlm.nih.gov/pubmed/20924011

1. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: A randomized control trial ( JAMA. 2010;304(13):1455–64)

9. Subject disposition

10. Demographics and baseline characteristics (N=1282)

11. Demographics and baseline characteristics (N=1282)

12. Demographics and baseline characteristics (N=1282)

13. Demographics and baseline characteristics (N=1282)

14. Demographics and baseline characteristics (N=1282)

15. Demographics and baseline characteristics (N=1282)

16. Imputation vs casewise deletion

17. Clinical outcomes

18. Clinical outcomes

19. Clinical outcomes

23. 1a. R- Was the assignment of patients to treatments randomised ?

24. 1b. R- Were the groups similar at the start of the trial?

25. 2a. A – Aside from the allocated treatment, were groups treated equally?

26. 2b. A – Were all patients who entered the trial accounted for? – and were they analysed in the groups to which they were randomised?

27. 3. M - Were measures objective or were the patients and clinicians kept “ blind ” to which treatment was being received?

28. How large was the treatment effect?

29. How precise was the estimate of the treatment effect?