SMC-RNA BioVis Data Visualization DREAM Challenge Preview
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SMC-RNA BioVis Data Visualization DREAM Challenge Preview http://biovis.net/2016/dream/
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SMC-RNA BioVis Data Visualization DREAM Challenge Preview
- 1. http://www.biovis.net/2016/dream SMC-RNA BioVis Data Visualization DREAM Challenge http://www.biovis.net/2016/dream
- 2. http://www.biovis.net/2016/dream What is a DREAM Challenge?
- 3. http://www.biovis.net/2016/dream • http://dreamchallenges.org • DREAM Challenges pose fundamental questions about systems biology and translational medicine. • Vision: Allowing individuals and groups to collaborate openly so that the “wisdom of the crowd” provides the greatest impact on science and human health. • DREAM was launched in 2006 by Gustavo Stolovitzky (IBM) in collaboration with Andrea Califano (Columbia University). Sage Bionetworks has been providing institutional support since 2013.
- 4. http://www.biovis.net/2016/dream What is the SMC-RNA DREAM Challenge?
- 5. http://www.biovis.net/2016/dream • https://www.synapse.org/#!Synapse:syn2813589/wiki/ 401435 • The challenge is to computationally predict gene/transcript fusions and transcript isoforms based on RNA-seq data. • This will yield many new tools and predictions for fusions and transcript isoforms.
- 6. http://www.biovis.net/2016/dream What are isoforms and fusions? Why are they important?
- 7. http://www.biovis.net/2016/dream Alternative Splicing Liu S, Cheng C. Alternative RNA splicing and cancer. Wiley interdisciplinary reviews RNA. 2013,4(5),547-566.
- 8. http://www.biovis.net/2016/dream Isoforms in Cancer Liu S, Cheng C. Alternative RNA splicing and cancer. Wiley interdisciplinary reviews RNA. 2013,4(5),547-566.
- 9. http://www.biovis.net/2016/dream Isoforms in Cancer Liu S, Cheng C. Alternative RNA splicing and cancer. Wiley interdisciplinary reviews RNA. 2013,4(5),547-566.
- 10. http://www.biovis.net/2016/dream Gene + Transcript Fusions Mertens, F., et al. (2015). The emerging complexity of gene fusions in cancer. Nature Reviews Cancer, 15(6), 371-381.
- 11. http://www.biovis.net/2016/dream Fusions in Cancer Mertens, F., et al. (2015). The emerging complexity of gene fusions in cancer. Nature Reviews Cancer, 15(6), 371-381.
- 12. http://www.biovis.net/2016/dream Fusions in Cancer Mertens, F., et al. (2015). The emerging complexity of gene fusions in cancer. Nature Reviews Cancer, 15(6), 371-381.
- 14. http://www.biovis.net/2016/dream Fusions in Cancer Mertens, F., et al. (2015). The emerging complexity of gene fusions in cancer. Nature Reviews Cancer, 15(6), 371-381.
- 15. http://www.biovis.net/2016/dream Fusions in Cancer Mertens, F., et al. (2015). The emerging complexity of gene fusions in cancer. Nature Reviews Cancer, 15(6), 371-381.
- 16. http://www.biovis.net/2016/dream What are we looking for?
- 17. http://www.biovis.net/2016/dream • What exactly we are looking for will be announced later this summer. • We won’t have any preconceived notion about what we will accept as solutions. • It will be important that the solution can be used to enhance our understanding of biology. • It needs to be usable by a wide range of investigators.
- 18. http://www.biovis.net/2016/dream What is the time line?
- 19. http://www.biovis.net/2016/dream • Anticipated launch in Summer 2016. • Submissions in Fall/Winter 2016. • The visualization challenge will be synchronized with the SMC-RNA challenge (https://www.synapse.org/#! Synapse:syn2813589/wiki/401435) • Unlike past data contests, this challenge is decoupled from the BioVis meetings.
- 20. http://www.biovis.net/2016/dream What are the incentives?
- 21. http://www.biovis.net/2016/dream What we aim for (but no promises): • All participants will be invited as consortium co-authors on Challenge marker papers • Winners will receive speaking invitations at the next DREAM conference or a future BioVis meeting • New methods will be considered for co-publication with the Challenge marker papers by our publishing partner • Other rewards will be announced as they are determined.
- 22. http://www.biovis.net/2016/dream Where to get more information and how to receive updates?
- 23. http://www.biovis.net/2016/dream 1. Go to www.biovis.net/2016/dream. 2. Follow link to Synapse Wiki.
- 24. http://www.biovis.net/2016/dream 3. Scroll down. 4. Click link to “Join” to pre-register.
- 26. http://www.biovis.net/2016/dream BioVis Team • Raghu Machiraju, The Ohio State University, USA • Cagatay Turkay, City University London, UK • Angela Brooks, University of California Santa Cruz, USA • Nils Gehlenborg, Harvard Medical School, USA Advisors and Support • Paul Boutros, OICR, Canada (SMC-RNA Challenge Leader) • Thea Norman, Sage Bionetworks, USA (DREAM Challenge Director)
- 27. http://www.biovis.net/2016/dream Do you have questions?