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Lupus Nephritis
 
RBC Casts
WHO Class I Lupus Nephritis Minimal Mesangial Immunoperoxidase staining shows C1q
WHO Class II Immunoperoxidase stain: Mesangial IgG deposits
WHO Class II Lupus Nephritis Mesangial Proliferative
WHO Class III Lupus Nephritis (Focal Proliferative) Hematoxylin/Lissamine Green Stain: ≤50% of the glomerular tuft involvement With areas of focal necrosis
WHO Class III Lupus Nephritis
WHO Class III Lupus Nephritis
WHO Class IV Lupus Nephritis Diffuse Proliferative Immunoperoxidase Stain: ≥50% of the Glomerular Tuft involved
WHO Class IV Lupus Nephritis H & E Stain: Diffuse increase in matrix and hypercellularity
WHO Class V  Membranous EM: Electron-dense immune deposits on the outer surface of BM, separated by “ spikes” of exuberant BM-like material (mainly laminin)
WHO Class V Lupus Nephritis Silver Methenamine Stain: Silver positive spikes along the peripheral capillary wall
WHO Class V Lupus Nephritis
WHO Class VI Lupus Nephritis Advanced Sclerosis Hematoxylin/Lissamine Green Stain: Sclerosis of ≥90% of the glomerulus
WHO Class VI Lupus Nephritis

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(IDE)and(IVD),QMS,21 CFR part820 , 801)
 

Lupus Nephritis

  • 2.  
  • 4. WHO Class I Lupus Nephritis Minimal Mesangial Immunoperoxidase staining shows C1q
  • 5. WHO Class II Immunoperoxidase stain: Mesangial IgG deposits
  • 6. WHO Class II Lupus Nephritis Mesangial Proliferative
  • 7. WHO Class III Lupus Nephritis (Focal Proliferative) Hematoxylin/Lissamine Green Stain: ≤50% of the glomerular tuft involvement With areas of focal necrosis
  • 8. WHO Class III Lupus Nephritis
  • 9. WHO Class III Lupus Nephritis
  • 10. WHO Class IV Lupus Nephritis Diffuse Proliferative Immunoperoxidase Stain: ≥50% of the Glomerular Tuft involved
  • 11. WHO Class IV Lupus Nephritis H & E Stain: Diffuse increase in matrix and hypercellularity
  • 12. WHO Class V Membranous EM: Electron-dense immune deposits on the outer surface of BM, separated by “ spikes” of exuberant BM-like material (mainly laminin)
  • 13. WHO Class V Lupus Nephritis Silver Methenamine Stain: Silver positive spikes along the peripheral capillary wall
  • 14. WHO Class V Lupus Nephritis
  • 15. WHO Class VI Lupus Nephritis Advanced Sclerosis Hematoxylin/Lissamine Green Stain: Sclerosis of ≥90% of the glomerulus
  • 16. WHO Class VI Lupus Nephritis