For my senior CEU pharmacy students in QC 2 with Instrumentation. The different types and examples of indicator electrodes used in potentiometric titration method of drug analysis.

1. CHAPTER 5
POTENTIOMETRY:
PRINCIPLES AND
THEORY
Asst. Prof. MA. LOURDES LICSI-MOJARES, RPh
Faculty, School of Pharmacy
CEU, Manila

2. POTENTIOMETRIC TITRATION:
DEFINITION
 A TECHNIQUE SIMILAR TO DIRECT
TITRATION OF A REDOX REACTION.
 NO INDICATOR IS USED.
 THE VOLTAGE ACROSS THE ANALYTE
(AN ELECTROLYTE SOLUTION) IS
MEASURED.

3. POTENTIOMETRIC TITRATION:
DEFINITION
TO DO THIS, 2 ELECTRODES ARE USED;
1. NEUTRAL ELECTRODE
2. STANDARD REFERENCE ELECTRODE
THE VOLTAGE IS RECORDED, AT
INTERVALS, AS THE TITRANT IS ADDED.

5. POTENTIOMETRIC TITRATION:
DEFINITION
 A GRAPH OF VOLTAGE AGAINST THE
VOLUME ADDED IS PLOTTED AND THE
ENDPOINT OF THE REACTION IS
HALFWAY BETWEEN THE JUMP IN
VOLTAGE.

6. POTENTIOMETRIC TITRATION
 THIS METHOD RELIES ON THE
MEASUREMENT OF ECELL FOR
QUANTITATIVE ANALYSIS.
 THE DIFFERENCE BETWEEN THE E
VALUES FOR THE 2 HALVES OF THE CELL
GIVES RISE TO THE ECELL .

7. POTENTIOMETRIC TITRATOR:
SCHEMATIC

22. POTENTIMETRIC TITRATION:
SETUP:

23. POTENTIOMETRIC TITRATION:
TYPES
 ACID-BASE TITRATIONS
 REDOX TITRATIONS
 PRECIPITATION TITRATIONS