SlideShare a Scribd company logo
1 of 25
بسبمس م الله الله االلر رححممن ا نل راحليــــــــ رمحيم
Oral Complications of Diabetes
Done by, 
Mohammad Mutni Al-Mutairi
Objective 
Defenition. 
Normal glocuse level. 
Oral complication of diabetes. 
Dental management of DM.
Diabetes mellitus is a clinically and 
genetically heterogeneous metabolic disease 
characterizd by abnormally elevatd blood 
glocuse level and dysregulation of 
carbohydrates,protein, and lipid metabolism
Normal glucose level 
Normal glocuse level 
Impaired 
fasting glucose 
normal 
Fasting glocuse >110mg/dl 110-126mg/dl 
2 h postprandial >140mg/dl 140-200mg/dl 
plasma glucose 
Diabetes mellitus 
<126mg/dl 
<200mg/dl
Oral Complications of 
Diabetes 
Oral dysesthesia 
xerostomia 
Salivary gland enlargement 
Salivary hypofunction 
Dry mucosal surface 
Dental caries 
Gingivitis and periodontitis
Oral dysesthesia 
Which include;- 
1) Burning mouth. 
2) Altered wound healing. 
3) Increase incidence of infection. 
4) Candidal infection.
xerostomia 
Decrease secretion of salivary gland.
Salivary gland enlargement 
Salivary gland enlargement 
or sialadenitis is inflammation 
of salivary gland especially in 
parotid gland and both are 
related to poor glycemic 
control.
Salivary hypofunction 
Medication taken by DM patient for 
related or unrelated systemic condition 
may produce salivary hypofunction.
Dry Mucosal Surface 
Caused by insufficient salivary output are 
easily irritated, causing; 
•Minor mucosal ulceration. 
•Oral burning sensation. 
•Increased overgrowth of fungal organism.
Minor mucosal ulceration.
Dental caries 
The high incidence and severity of dental 
caries in DM patient have been associated 
with;- 
•Xerostomia. 
•Increase gingival crevicular fluid glocuse 
level. 
•Increase dental plaque accumulation.
Dental caries
dental plaque accumulation
Gingivitis and Periodontitis 
DM also an established risk factor for the 
prevalence and severity of gingivitis and 
periodontitis. 
Progressive destructive periodontitis is 
more common in patient with poor glycemic 
control. 
Poor hygiene and smoking contribute to the 
increased incidence and severity of 
periodontitis.
gingivitis
Periodontitis
Dental Mangement of 
DM 
Treatment the causes. 
Control glocuse level 
There is some risk factor may increase the 
dental problem as a follow; 
- Concomitant medical problems 
- Diet 
- Oral hygiene 
- Habits
References 
GREENBERG -M,S. Ulcerative, Vesicular, 
and Bullous 
Lesion.Greenberg,m,s.Burkets oral 
medicine.Eleventh edition.2008; chapter 21
Thank you

More Related Content

What's hot

Dental considerations in daibetes patient
Dental considerations in daibetes patientDental considerations in daibetes patient
Dental considerations in daibetes patient
Payoj Chaudhary
 

What's hot (20)

Systemic periodontology
Systemic periodontologySystemic periodontology
Systemic periodontology
 
atraumatic restorative treatment
atraumatic restorative treatmentatraumatic restorative treatment
atraumatic restorative treatment
 
Gingivectomy
Gingivectomy Gingivectomy
Gingivectomy
 
Disclosing agents
Disclosing agentsDisclosing agents
Disclosing agents
 
Dental management of a diabetic patient
Dental  management of a diabetic patientDental  management of a diabetic patient
Dental management of a diabetic patient
 
Host modulation therapy
Host modulation therapyHost modulation therapy
Host modulation therapy
 
Periodontal medicine
Periodontal medicinePeriodontal medicine
Periodontal medicine
 
4.furcation involvement and its treatment
4.furcation involvement and its treatment4.furcation involvement and its treatment
4.furcation involvement and its treatment
 
Periodontal examination and diagnosis
Periodontal examination and diagnosisPeriodontal examination and diagnosis
Periodontal examination and diagnosis
 
Periodontal probe and explorer
Periodontal probe and explorerPeriodontal probe and explorer
Periodontal probe and explorer
 
Dental Management of Patient with Diabetes Mellitus Presentation
Dental Management of Patient with Diabetes Mellitus PresentationDental Management of Patient with Diabetes Mellitus Presentation
Dental Management of Patient with Diabetes Mellitus Presentation
 
dry socket
dry socketdry socket
dry socket
 
Chronic gingivitis
Chronic gingivitisChronic gingivitis
Chronic gingivitis
 
Case history, diagnosis and treatment planning
Case history, diagnosis and treatment planningCase history, diagnosis and treatment planning
Case history, diagnosis and treatment planning
 
Periodontal instruments
Periodontal instruments Periodontal instruments
Periodontal instruments
 
Cracked tooth syndrome in an
Cracked tooth syndrome in anCracked tooth syndrome in an
Cracked tooth syndrome in an
 
Isolation of the operative field
Isolation of the operative fieldIsolation of the operative field
Isolation of the operative field
 
Impaction
Impaction Impaction
Impaction
 
Dental considerations in daibetes patient
Dental considerations in daibetes patientDental considerations in daibetes patient
Dental considerations in daibetes patient
 
Local Anesthesia in Oral and Maxillofacial Surgery
Local Anesthesia in Oral and Maxillofacial SurgeryLocal Anesthesia in Oral and Maxillofacial Surgery
Local Anesthesia in Oral and Maxillofacial Surgery
 

Viewers also liked (12)

Diabetes Mellitus patients in dental management
Diabetes Mellitus patients in dental managementDiabetes Mellitus patients in dental management
Diabetes Mellitus patients in dental management
 
Diabetes mellitus & oral surgery
Diabetes mellitus & oral surgeryDiabetes mellitus & oral surgery
Diabetes mellitus & oral surgery
 
Management of a diabetic patient in dental office
Management of a diabetic patient in dental officeManagement of a diabetic patient in dental office
Management of a diabetic patient in dental office
 
Diabetes mealitus &periodontal disease
Diabetes mealitus &periodontal diseaseDiabetes mealitus &periodontal disease
Diabetes mealitus &periodontal disease
 
Diabetes and periodontitis
Diabetes and periodontitisDiabetes and periodontitis
Diabetes and periodontitis
 
Diabetes and periodontal disease ,at two way relationship
Diabetes and periodontal disease ,at two way relationshipDiabetes and periodontal disease ,at two way relationship
Diabetes and periodontal disease ,at two way relationship
 
DENTAL MANAGEMENT OF THE MEDICALLY COMPROMISED PATIENT DENTAL MANAGEMENT OF...
DENTAL MANAGEMENT OF THE MEDICALLY COMPROMISED PATIENT 	 DENTAL MANAGEMENT OF...DENTAL MANAGEMENT OF THE MEDICALLY COMPROMISED PATIENT 	 DENTAL MANAGEMENT OF...
DENTAL MANAGEMENT OF THE MEDICALLY COMPROMISED PATIENT DENTAL MANAGEMENT OF...
 
Management of medical emergencies in the dental practice
Management of medical emergencies in the dental practiceManagement of medical emergencies in the dental practice
Management of medical emergencies in the dental practice
 
Management of medically compromised patients
Management of medically compromised patientsManagement of medically compromised patients
Management of medically compromised patients
 
HYPERTENSION & ITS MANAGEMENT IN DENTISTRY
HYPERTENSION & ITS MANAGEMENT IN DENTISTRYHYPERTENSION & ITS MANAGEMENT IN DENTISTRY
HYPERTENSION & ITS MANAGEMENT IN DENTISTRY
 
Dental management of medically compromized patients
Dental management of medically compromized patientsDental management of medically compromized patients
Dental management of medically compromized patients
 
Medical emergencies dental office
Medical emergencies dental officeMedical emergencies dental office
Medical emergencies dental office
 

Similar to Oral Complications of Diabetes

Gingival Enlargementdental periodontal.pptx
Gingival Enlargementdental periodontal.pptxGingival Enlargementdental periodontal.pptx
Gingival Enlargementdental periodontal.pptx
MohamedYElZahar
 

Similar to Oral Complications of Diabetes (20)

Periodontal disease and diabetes a study.
Periodontal disease and diabetes a study.Periodontal disease and diabetes a study.
Periodontal disease and diabetes a study.
 
gingival and periodontal diseases
gingival and periodontal diseasesgingival and periodontal diseases
gingival and periodontal diseases
 
GINGIVAL ENLARGEMENT
GINGIVAL ENLARGEMENTGINGIVAL ENLARGEMENT
GINGIVAL ENLARGEMENT
 
The oral diseases Gingivitis
The oral diseases GingivitisThe oral diseases Gingivitis
The oral diseases Gingivitis
 
Oral manifestation of Systemic Diseases
Oral manifestation of Systemic DiseasesOral manifestation of Systemic Diseases
Oral manifestation of Systemic Diseases
 
Dental
DentalDental
Dental
 
Chemical injuries On Oral Cavity
Chemical injuries On Oral CavityChemical injuries On Oral Cavity
Chemical injuries On Oral Cavity
 
Gum Disease Demystified
Gum Disease DemystifiedGum Disease Demystified
Gum Disease Demystified
 
Periodontal diseases in children
Periodontal diseases in childrenPeriodontal diseases in children
Periodontal diseases in children
 
Conditioned gingivitis
Conditioned gingivitisConditioned gingivitis
Conditioned gingivitis
 
SALIVARY GLAND DISORDER AND XEROSTOMIA
SALIVARY GLAND DISORDER AND XEROSTOMIASALIVARY GLAND DISORDER AND XEROSTOMIA
SALIVARY GLAND DISORDER AND XEROSTOMIA
 
Gingivitis Vs Periodontitis
Gingivitis Vs PeriodontitisGingivitis Vs Periodontitis
Gingivitis Vs Periodontitis
 
Oral manifestations of gastrointestinal disorders
Oral manifestations of gastrointestinal disordersOral manifestations of gastrointestinal disorders
Oral manifestations of gastrointestinal disorders
 
Understanding Gingivitis.pptx
Understanding Gingivitis.pptxUnderstanding Gingivitis.pptx
Understanding Gingivitis.pptx
 
Gingival enlargement
Gingival enlargementGingival enlargement
Gingival enlargement
 
Geriatric Dentistry
 Geriatric Dentistry  Geriatric Dentistry
Geriatric Dentistry
 
Gingival Enlargementdental periodontal.pptx
Gingival Enlargementdental periodontal.pptxGingival Enlargementdental periodontal.pptx
Gingival Enlargementdental periodontal.pptx
 
GINGIVAL and PERIODONTAL DISEASE.ppt
GINGIVAL and  PERIODONTAL DISEASE.pptGINGIVAL and  PERIODONTAL DISEASE.ppt
GINGIVAL and PERIODONTAL DISEASE.ppt
 
project-150219172648-conversion-gate01.pdf
project-150219172648-conversion-gate01.pdfproject-150219172648-conversion-gate01.pdf
project-150219172648-conversion-gate01.pdf
 
Oral manifestations of gastrointestinal disorders.ppt
Oral manifestations of gastrointestinal disorders.pptOral manifestations of gastrointestinal disorders.ppt
Oral manifestations of gastrointestinal disorders.ppt
 

Recently uploaded

💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
Sheetaleventcompany
 
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
Sheetaleventcompany
 
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
Sheetaleventcompany
 
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
Sheetaleventcompany
 
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
Sheetaleventcompany
 
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
Sheetaleventcompany
 

Recently uploaded (20)

Cardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their RegulationCardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their Regulation
 
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
(RIYA)🎄Airhostess Call Girl Jaipur Call Now 8445551418 Premium Collection Of ...
 
💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...
 
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...
 
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
 
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...
 
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room DeliveryCall 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery
 
Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...
Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...
Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...
 
7 steps How to prevent Thalassemia : Dr Sharda Jain & Vandana Gupta
7 steps How to prevent Thalassemia : Dr Sharda Jain & Vandana Gupta7 steps How to prevent Thalassemia : Dr Sharda Jain & Vandana Gupta
7 steps How to prevent Thalassemia : Dr Sharda Jain & Vandana Gupta
 
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
❤️Amritsar Escorts Service☎️9815674956☎️ Call Girl service in Amritsar☎️ Amri...
 
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
Race Course Road } Book Call Girls in Bangalore | Whatsapp No 6378878445 VIP ...
 
Circulatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanismsCirculatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanisms
 
Call Girls Mussoorie Just Call 8854095900 Top Class Call Girl Service Available
Call Girls Mussoorie Just Call 8854095900 Top Class Call Girl Service AvailableCall Girls Mussoorie Just Call 8854095900 Top Class Call Girl Service Available
Call Girls Mussoorie Just Call 8854095900 Top Class Call Girl Service Available
 
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
Pune Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Pune No💰Adva...
 
Kolkata Call Girls Shobhabazar 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Gir...
Kolkata Call Girls Shobhabazar  💯Call Us 🔝 8005736733 🔝 💃  Top Class Call Gir...Kolkata Call Girls Shobhabazar  💯Call Us 🔝 8005736733 🔝 💃  Top Class Call Gir...
Kolkata Call Girls Shobhabazar 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Gir...
 
❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...
❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...
❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...
 
Low Cost Call Girls Bangalore {9179660964} ❤️VVIP NISHA Call Girls in Bangalo...
Low Cost Call Girls Bangalore {9179660964} ❤️VVIP NISHA Call Girls in Bangalo...Low Cost Call Girls Bangalore {9179660964} ❤️VVIP NISHA Call Girls in Bangalo...
Low Cost Call Girls Bangalore {9179660964} ❤️VVIP NISHA Call Girls in Bangalo...
 
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
💚Chandigarh Call Girls Service 💯Piya 📲🔝8868886958🔝Call Girls In Chandigarh No...
 
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
Kolkata Call Girls Service ❤️🍑 9xx000xx09 👄🫦 Independent Escort Service Kolka...
 
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
Call girls Service Phullen / 9332606886 Genuine Call girls with real Photos a...
 

Oral Complications of Diabetes

  • 1. بسبمس م الله الله االلر رححممن ا نل راحليــــــــ رمحيم
  • 3. Done by, Mohammad Mutni Al-Mutairi
  • 4. Objective Defenition. Normal glocuse level. Oral complication of diabetes. Dental management of DM.
  • 5. Diabetes mellitus is a clinically and genetically heterogeneous metabolic disease characterizd by abnormally elevatd blood glocuse level and dysregulation of carbohydrates,protein, and lipid metabolism
  • 6. Normal glucose level Normal glocuse level Impaired fasting glucose normal Fasting glocuse >110mg/dl 110-126mg/dl 2 h postprandial >140mg/dl 140-200mg/dl plasma glucose Diabetes mellitus <126mg/dl <200mg/dl
  • 7. Oral Complications of Diabetes Oral dysesthesia xerostomia Salivary gland enlargement Salivary hypofunction Dry mucosal surface Dental caries Gingivitis and periodontitis
  • 8. Oral dysesthesia Which include;- 1) Burning mouth. 2) Altered wound healing. 3) Increase incidence of infection. 4) Candidal infection.
  • 9.
  • 10.
  • 11. xerostomia Decrease secretion of salivary gland.
  • 12. Salivary gland enlargement Salivary gland enlargement or sialadenitis is inflammation of salivary gland especially in parotid gland and both are related to poor glycemic control.
  • 13.
  • 14. Salivary hypofunction Medication taken by DM patient for related or unrelated systemic condition may produce salivary hypofunction.
  • 15. Dry Mucosal Surface Caused by insufficient salivary output are easily irritated, causing; •Minor mucosal ulceration. •Oral burning sensation. •Increased overgrowth of fungal organism.
  • 17. Dental caries The high incidence and severity of dental caries in DM patient have been associated with;- •Xerostomia. •Increase gingival crevicular fluid glocuse level. •Increase dental plaque accumulation.
  • 20. Gingivitis and Periodontitis DM also an established risk factor for the prevalence and severity of gingivitis and periodontitis. Progressive destructive periodontitis is more common in patient with poor glycemic control. Poor hygiene and smoking contribute to the increased incidence and severity of periodontitis.
  • 23. Dental Mangement of DM Treatment the causes. Control glocuse level There is some risk factor may increase the dental problem as a follow; - Concomitant medical problems - Diet - Oral hygiene - Habits
  • 24. References GREENBERG -M,S. Ulcerative, Vesicular, and Bullous Lesion.Greenberg,m,s.Burkets oral medicine.Eleventh edition.2008; chapter 21