1. TARGET SEARCH
VON JANNEKE MES & LUKAS FRIEDEHEIM
MAASTRICHT UNIVERSITY – MAASTRICHT SCIENCE PROGRAMME

2. INTRODUCTION
• Main question: What are the interactions of two substances affecting
the same
target?
• Same targets of two different substances?
• Targets (only single protein) of one given substance?

3. METHOD: LIBRARIES & SOURCE FILES
•
•
lib/jquery-1.9.1.min.js
•
•
•
•
src/OPS.js
lib/purl.js
src/ConceptWikiSearch.js
src/CompoundSearch.js
http://d3js.org/d3.v3.min.js

4. METHOD: FUNCTIONS
• ConceptWikiSearch:
• gives URI for the desired compound
• CompoundSearch (compoundPharmacology):
• give target interactions of desired compound

5. METHOD: DATA
• JSON output from conceptWikiSearch to get URI
• JSON output from compoundPharmacology to get target
singleProteins of compound

6. D3 VISUALISATION
• Cluster dendogram

7. RESULTS
Shows single proteins affected by given substance in
an awesome looking cluster dendogram

8. SUMMARY
• Input search  Get compound URI from conceptWiki
• Click on desired compound  get target interactions from
compoundPharmacology
• D3 visualisation appears only showing single protein targets

9. EVALUATION
• Comparing search for two substances at the same time not possible
so far
• Direct compound  target search possible but mapping does not
support required URI format