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A Dose of Cohen: A Doctor Afield
Kim Solez, MD, FRCPC (Pathology) with Peter North (Executive
Producer, Leonard Cohen International Event, July 25-27,
2008 at the Winspear Concert Hall and Westin Hotel)
Mixing and Matching Medicine and Culture
 Beginning

with most familiar medical topic for me, the
Banff Classification of Kidney Transplant Pathology.
 Diverging to show how in 2002 in preparation for the
2003 Banff meeting in Scotland I suddenly ventured
into the realm of Leonard Cohen events.
 Presenting the history of those Leonard Cohen events,
the way my experience with organizing medical
meetings shaped Leonard Cohen events, and the way
they in turn influenced medical initiatives.
 Description of plans for July 23-28, 2008 Edmonton
International Leonard Cohen Event. (with Peter North)
 Conclusions.
Communications - Getting the Word Out
 Since

1997 I have headed NKF cyberNephrology with
resources, email discussion groups and websites, that
reach 8,000 people.
 Technofuturism material published on ThinkerNet Blog
http://www.internetevolution.com that receives 300,000
visitors a month. My pieces have been the “editor’s
pick” there.
Lessons from the Arts brought to Medicine
Critical Path for Event Planning/Philosophy/Writing
 ARTS:

Keeping track of activities via hand held
devices. Security considerations.
 MEDICINE: Hand held devices ideal for securely
keeping track of progress of kidney biopsy light
microscopy, immunofluorescence, electron
microscopy.
 ARTS: Philosophical influences on culture.
 MEDICINE: Philosophical influences on medicine
understudied except for bioethics. Gene chip vs.
conventional pathology.
 ARTS: Pride in writing as writing.
 MEDICINE: Pride in writing as writing.
Promotion/Capturing the Imagination of the Public
 ARTS:

Promotion. Media attention. Capturing the
imagination of the public is important.

 MEDICINE:

Promotion. Media attention. Capturing the
imagination of the public is important.
Lessons from Medicine brought to the Arts
Leonard Cohen remarks
 “Living

life with microscopic precision”
Meetings - A Waste of Time?


“Medical meetings are just social events. Nothing important happens at
them. They are a waste of time. You should avoid organizing medical
meetings.” - Robert H. Heptinstall, M.D.



I did not follow this advice. Doctors need to be socialized, humanized.
Organized my first Acute Renal Failure Symposium in 1982, published as
a book in 1984 Acute Renal Failure: Correlations Between Morphology
and Function. Many others since then.



My work on acute renal failure in the native kidney since 1972 gradually
led to an interest in acute renal failure in the transplanted kidney.
Background – The Banff Classification
 Acute

renal failure in the transplanted kidney is a high
stakes situation
 Many different entities have the same clinical
presentation:
 ATN,

acute rejection, CsA, FK506 toxicity
 misdiagnosis can rapidly lead to loss of the graft or
sometimes the patient
Background – The Banff Classification
 In

1990 all standard textbooks were inaccurate in
interpretation of kidney transplant biopsies
 Suggesting,

for example, that arteritis meant that the
kidney was doomed and antirejection treatment should be
abandoned

 It

became imperative for the field to correct this and
standardize interpretation
he Banff Schema was first developed by aby a
The Banff Schema was first developed
roup of pathologists, nephrologists, and
group of pathologists, nephrologists, and
ansplant surgeonsat a a meetingBanff Canada
transplant surgeons at meeting in in Banff Canada
ugust 2-4, 1991.
August 2-4, 1991.

It has continued to evolve through
meetings every two years and has
become the worldwide standard for
interpretation of transplant biopsies.
DIAGNOSTIC CATEGORIES







1. Normal
2. Antibody-mediated rejection,
3. Borderline changes: ‘Suspicious’ for acute cellular rejection
4. T-cell-mediated rejection (may coincide with categories 2
and 5 and 6)
5. Sclerosis, interstitial fibrosis, and tubular atrophy, no
evidence of any specific etiology
6. Other Changes not considered to be due to rejection
LESION SCORING (0-3+)
Transplant glomerulitis - g
Chronic transplant glomerulopathy - cg
Interstitial Inflammation - i (ti)
Interstitial fibrosis - ci
Tubulitis - t
Tubular atrophy - ct
Vasculitis, intimal arteritis - v
Fibrous intimal thickening - cv
Arteriolar hyaline thickening - ah (aah)
Mesangial matrix increase - mm
Peritubular capillary cell accumulation - ptc
FUTURE BANFF MEETINGS:

2009 - Banff, Alberta, Canada
 2011 - Paris, France
 2013 – Comandatuba, Bahia, Brazil
 2015 – Vancouver, Canada
 2017 - Barcelona, Spain
 2019 – Pittsburgh, PA, USA

BANFF CONFERENCES ON
ALLOGRAFT PATHOLOGY 1991-?
GLOBAL CONSENSUS GENERATION
WHILE MAINTAINING INTELLECTUAL
FREEDOM.
LIKE THE MOSH PIT AT A GREAT ROCK CONCERT.
NO PARTNER, THE ULTIMATE IN INDIVIDUALITY,
DANGEROUS, BUT WHEN THE MUSIC IS GOOD
EVERYONE DANCES IN SYNC AND LIFE IS GOOD!
BANFF CLASSIFICATION: MILESTONES















1991 First Conference
1993 First Kidney International publication
1995 Integration with CADI
1997 Integration with CCTT classification
1999 Second KI paper. Clinical practice guidelines. Implantation
biopsies, microwave.
2001 Classification of antibody-mediated rejection
 Regulatory agencies participating
2003 Genomics focus, peritubular capillary cell accumulation scoring Aberdeen, Scotland (first meeting held elsewhere)
2005 Gene chip analysis. Elimination of CAN, identification of chronic
antibody-mediated rejection.
2007 First meeting far from a town called “Banff” – La Coruna, Spain.
2009 Last Meeting in Banff, Canada.
It all began with a boring evening in a Scottish
pub miles outside of Aberdeen in January 2002
2002 Event
2003
2004
2005
2006
2007
Leonard Cohen International Events
2000 - Montreal
 2002 - Hydra, Greece
 2004 - New York City
 2006 - Berlin
 2008 - Edmonton
 2010 - Krakow, Poland


Edmonton has had yearly Leonard Cohen Nights in
September celebrating Leonard’s birthday 2002-2011
Major event planned for 2016.
2008 performers featured in slides to follow.
Jann Arden

Jann Arden
Serena Ryder

Serena Ryder
Peter Elkas
Roddy Hart
Darrell Scott
Tom Rush

Tom Rush
Ann Vriend
Ted Bishop

Ted Bishop
Todd Babiak
Vicky Hines

Vicky Hines
Karla Anderson

Karla Anderson
Clinker

Clinker
Kate Hammett-Vaughan
Kate Hammett-Vaughan
Monsieur Camembert
Monsieur Camembert
Larisa Sembaliuk Cheladyn
Conclusions
 July

23-28, 2008 Leonard Cohen Festival will be a
major cultural event. Come and enjoy!
http://www.leonardcohennights.org/2008.html
 Arts and culture make medicine better.
 Medicine makes arts and culture better.

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A Dose of Cohen: Mixing Medicine and Culture

  • 1. A Dose of Cohen: A Doctor Afield Kim Solez, MD, FRCPC (Pathology) with Peter North (Executive Producer, Leonard Cohen International Event, July 25-27, 2008 at the Winspear Concert Hall and Westin Hotel)
  • 2. Mixing and Matching Medicine and Culture  Beginning with most familiar medical topic for me, the Banff Classification of Kidney Transplant Pathology.  Diverging to show how in 2002 in preparation for the 2003 Banff meeting in Scotland I suddenly ventured into the realm of Leonard Cohen events.  Presenting the history of those Leonard Cohen events, the way my experience with organizing medical meetings shaped Leonard Cohen events, and the way they in turn influenced medical initiatives.  Description of plans for July 23-28, 2008 Edmonton International Leonard Cohen Event. (with Peter North)  Conclusions.
  • 3. Communications - Getting the Word Out  Since 1997 I have headed NKF cyberNephrology with resources, email discussion groups and websites, that reach 8,000 people.  Technofuturism material published on ThinkerNet Blog http://www.internetevolution.com that receives 300,000 visitors a month. My pieces have been the “editor’s pick” there.
  • 4.
  • 5. Lessons from the Arts brought to Medicine Critical Path for Event Planning/Philosophy/Writing  ARTS: Keeping track of activities via hand held devices. Security considerations.  MEDICINE: Hand held devices ideal for securely keeping track of progress of kidney biopsy light microscopy, immunofluorescence, electron microscopy.  ARTS: Philosophical influences on culture.  MEDICINE: Philosophical influences on medicine understudied except for bioethics. Gene chip vs. conventional pathology.  ARTS: Pride in writing as writing.  MEDICINE: Pride in writing as writing.
  • 6. Promotion/Capturing the Imagination of the Public  ARTS: Promotion. Media attention. Capturing the imagination of the public is important.  MEDICINE: Promotion. Media attention. Capturing the imagination of the public is important.
  • 7. Lessons from Medicine brought to the Arts Leonard Cohen remarks  “Living life with microscopic precision”
  • 8. Meetings - A Waste of Time?  “Medical meetings are just social events. Nothing important happens at them. They are a waste of time. You should avoid organizing medical meetings.” - Robert H. Heptinstall, M.D.  I did not follow this advice. Doctors need to be socialized, humanized. Organized my first Acute Renal Failure Symposium in 1982, published as a book in 1984 Acute Renal Failure: Correlations Between Morphology and Function. Many others since then.  My work on acute renal failure in the native kidney since 1972 gradually led to an interest in acute renal failure in the transplanted kidney.
  • 9. Background – The Banff Classification  Acute renal failure in the transplanted kidney is a high stakes situation  Many different entities have the same clinical presentation:  ATN, acute rejection, CsA, FK506 toxicity  misdiagnosis can rapidly lead to loss of the graft or sometimes the patient
  • 10. Background – The Banff Classification  In 1990 all standard textbooks were inaccurate in interpretation of kidney transplant biopsies  Suggesting, for example, that arteritis meant that the kidney was doomed and antirejection treatment should be abandoned  It became imperative for the field to correct this and standardize interpretation
  • 11. he Banff Schema was first developed by aby a The Banff Schema was first developed roup of pathologists, nephrologists, and group of pathologists, nephrologists, and ansplant surgeonsat a a meetingBanff Canada transplant surgeons at meeting in in Banff Canada ugust 2-4, 1991. August 2-4, 1991. It has continued to evolve through meetings every two years and has become the worldwide standard for interpretation of transplant biopsies.
  • 12. DIAGNOSTIC CATEGORIES       1. Normal 2. Antibody-mediated rejection, 3. Borderline changes: ‘Suspicious’ for acute cellular rejection 4. T-cell-mediated rejection (may coincide with categories 2 and 5 and 6) 5. Sclerosis, interstitial fibrosis, and tubular atrophy, no evidence of any specific etiology 6. Other Changes not considered to be due to rejection
  • 13. LESION SCORING (0-3+) Transplant glomerulitis - g Chronic transplant glomerulopathy - cg Interstitial Inflammation - i (ti) Interstitial fibrosis - ci Tubulitis - t Tubular atrophy - ct Vasculitis, intimal arteritis - v Fibrous intimal thickening - cv Arteriolar hyaline thickening - ah (aah) Mesangial matrix increase - mm Peritubular capillary cell accumulation - ptc
  • 14. FUTURE BANFF MEETINGS: 2009 - Banff, Alberta, Canada  2011 - Paris, France  2013 – Comandatuba, Bahia, Brazil  2015 – Vancouver, Canada  2017 - Barcelona, Spain  2019 – Pittsburgh, PA, USA 
  • 15. BANFF CONFERENCES ON ALLOGRAFT PATHOLOGY 1991-?
  • 16. GLOBAL CONSENSUS GENERATION WHILE MAINTAINING INTELLECTUAL FREEDOM.
  • 17. LIKE THE MOSH PIT AT A GREAT ROCK CONCERT. NO PARTNER, THE ULTIMATE IN INDIVIDUALITY, DANGEROUS, BUT WHEN THE MUSIC IS GOOD EVERYONE DANCES IN SYNC AND LIFE IS GOOD!
  • 18. BANFF CLASSIFICATION: MILESTONES           1991 First Conference 1993 First Kidney International publication 1995 Integration with CADI 1997 Integration with CCTT classification 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. 2001 Classification of antibody-mediated rejection  Regulatory agencies participating 2003 Genomics focus, peritubular capillary cell accumulation scoring Aberdeen, Scotland (first meeting held elsewhere) 2005 Gene chip analysis. Elimination of CAN, identification of chronic antibody-mediated rejection. 2007 First meeting far from a town called “Banff” – La Coruna, Spain. 2009 Last Meeting in Banff, Canada.
  • 19. It all began with a boring evening in a Scottish pub miles outside of Aberdeen in January 2002
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  • 22. 2003
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  • 24. 2004
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  • 26. 2005
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  • 28. 2006
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  • 30. 2007
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  • 32. Leonard Cohen International Events 2000 - Montreal  2002 - Hydra, Greece  2004 - New York City  2006 - Berlin  2008 - Edmonton  2010 - Krakow, Poland  Edmonton has had yearly Leonard Cohen Nights in September celebrating Leonard’s birthday 2002-2011 Major event planned for 2016. 2008 performers featured in slides to follow.
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  • 62. Conclusions  July 23-28, 2008 Leonard Cohen Festival will be a major cultural event. Come and enjoy! http://www.leonardcohennights.org/2008.html  Arts and culture make medicine better.  Medicine makes arts and culture better.