Heather Graves, from Department of English and Film Studies, in Faculty of Arts.
First teaching session 2011 Recent teaching session 2012
1. Increase course enrollment both externally and locally2. Add additional topics to broaden multidisciplinary nature of course still further3. Replicate course widely elsewhere4. Masters student in College of Pharmacy, Qatar University, Doha, Qatar joining us by Skype
1) How I came to create this course2) How it fits into my career path3) How it relates to Banff Allograft Pathology Consensus Process and Nepal Initiative4) How it relates to Future of Pathology
1) In 1994 created websites for CAP, ISN, and RPS and NEPHROL Email discussion group2) In 1997 created NKF CyberNephrology and ISN Informatics Commission3) In 1999 new Lab Medicine Pathology chair, Victor Tron, suggested I broaden focus to CyberMedicine, and encouraged medical humanitarian ventures
1) In 2007 joined medical advisory board of new medical school in Nepal devoted to rural health, Patan Academy of Health Sciences (“PAHS”).2) Now co-direct fundraising and public relations for PAHS, ten UofA faculty are now involved in the project.
1) Tech musings from the Hinterland. Virtual microscopy one topic.2) The first video was from Nepal.
In February 2011 began writing book on the same day the Singularity appeared on the cover of Time magazine.
In 1990 all standard textbooks were inaccurate in interpretation of kidney transplant biopsies ◦ Suggesting, for example, that arteritis meant that the kidney was doomed and antirejection treatment should be abandoned It became imperative for the field to correct this and standardize interpretation Singularity Course
.The Banff Schemawas first developed by a group of pathologists, nephrologists, and transplant surgeons at a meeting in Banff Canada August 2-4, 1991.. It has continued to evolve through meetings every two years and has become the worldwide standard for interpretation of transplant biopsies
• Began in kidney (Solez et al. 1993), and was then extended to liver, pancreas, compo site tissue grafts etc. Meetings also consider heart, lung, small bowel.• Uses semi- quantitative lesion scoring 0-3+ and diagnostic categories.
A principal investigator in Phil Halloran‟s 18 Million Dollar Genome Canada transplant transcriptome project. Affymetrix GeneChip® probe array. Image courtesy of Affymetrix. The prime mover behind the Banff Conferences and Classification which mainly uses techniques of thirty to fifty years ago. BANFF Cybernephrology
1991 First Conference 1993 First Kidney International publication 1995 Integration with CADI 1997 Integration with CCTT classification 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. 2001 Classification of antibody-mediated rejection ◦ Regulatory agencies participating 2003 Genomics focus, ptc cell accumulation scoring 2005 Gene chip analysis. Elimination of CAN, identification of chronic antibody-mediated rejection. 2007 First meeting far from a town called ―Banff‖ – La Coruna, Spain. 2009 Working groups. Meeting in Banff, Alberta, Canada for last time until 2017! Singularity Course
Normal Antibody-mediated rejection, Borderline changes: „Suspicious‟ for acute cellular rejection T-cell-mediated rejection (may coincide with categories 2 and 5 and 6) Sclerosis, interstitial fibrosis, and tubular atrophy, no evidence of any specific etiology Other changes not considered to be due to rejection
Classification begun at 1991 Banff meeting has become the worldwide standard, and the consensus process has now extended to all solid organs. Meetings continue every two years. Latest meeting was in Paris in June 2011. Future meetings are planned every two years through 2019. Standardization principles now being extended from biopsy reporting to tissue typing, imaging, all the other elements in transplant care. Singularity Course
2013 – Campos do Jordao, Sao Paulo, Brazil 2015 – Istanbul, Turkey 2017 – Banff, Alberta, Canada. 2019 – Barcelona, Spain 2021– Make a proposal! Singularity Course
Like the mosh pit at a great rock concert. No partner, the ultimate in individuality, dangerous , but when the music is good everyone dances in sync and life is good!
• Until now we have had none beyond Drs. Racusen and Solez.• Plan to form Swiss foundation, a legal entity, in 2012.
It is hard to believe we have been at this for twenty years! Images from 1991
Despite a primitive beginning 21 years ago all the high tech ideas we talk about in this course are infusing their way into the Banff consensus process & meetings—completing the cycle