Mitosis

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The document describes the stages of mitosis and why cell division is important. It explains that cell growth requires cell division and that mitosis allows cells to be replaced when healing from injuries. The stages of mitosis are then defined as prophase, metaphase, anaphase, and telophase where the chromosomes condense, align, separate to opposite sides of the cell, and new cell nuclei form.

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The study of the cell cycle focuses on mechanisms that regulate the timing and frequency of DNA duplication and cell division. As a biological concept, the cell cycle is defined as the period between successive divisions of a cell. During this period, the contents of the cell must be accurately replicated. The cell cycle is regulated by cyclins and cyclin-dependent kinases. How long is one cell cycle? Depends. Eg. Skin cells every 24 hours. Some bacteria every 2 hours. Some cells every 3 months. Cancer cells very short. Nerve cells never. Programmed cell death: Each cell type will only do so many cell cycles then die. (Apoptosis)

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The non-profit sector has grown rapidly if measured by the number of organizations. Alas, it is also shrinking by the more meaningful measure of private giving as a share of national income; on this score it is down 11%. A smaller pie and more mouths to feed is a recipe for disaster and yet, status quo thinking and activity dominate within organizations. The growth curve can be bent but only with a willingness to do business much differently. In the realms of computer science, operations research and management science lives the world of mathematical optimization, conceptually a very simple concept, with the purpose of finding the best approach from a set of available alternatives. This definition could just as easily be applied to fundraising strategy, and even life. There is however one insidious concern with optimization; what if the set of alternatives we are optimizing or choosing amongst is not complete? What if we have unintentionally omitted the best alternative from consideration? Unknowingly the “optimum” isn’t optimum at all, merely the best of our not- so- best options. Mathematicians call this “local optimization” versus “global optimization” with the former representing identification of a “winner” among a set of choices that does not include the overall (or global) best choice. This global versus local phenomenon is very useful when conceptually considering the lack of growth in non-profit fundraising and how to fix it.

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