A 54-year-old woman with a history of dermatomyositis since 2005 presented with painful calcinosis cutis lesions on her lower back and right hip that were causing incapacitation. Previous treatments including prednisone, azathioprine, diltiazem, alendronate, colchicine, aluminum hydroxide, and hydroxychloroquine provided no improvement. An article was cited proposing intravenous immunoglobulin therapy for calcinosis cutis associated with dermatomyositis. The question is whether intravenous immunoglobulin would be a reasonable therapeutic option for this patient.