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Neuroplasticity
               Tutorial

         By: Dr Madhumita Sen
Introduction
• What is brain plasticity?
• Does it mean that our brains are made of
  plastic?
• Of course not!
• Plasticity, or neuroplasticity, is the lifelong
  ability of the brain to reorganize neural
  pathways based on new experiences.
• As we learn, we acquire new knowledge
  and skills through instruction or experience
• Definition: Neural plasticity, which is also
  known as neuroplasticity, brain plasticity,
  cortical plasticity, is the changing of the
  structure, function, and organization of
  neurons in response to new experiences.

• Neural plasticity specifically refers to
  strengthening or weakening nerve
  connections or adding new nerve cells based
  on outside experiences.
How
Paths
are
created
• In some cases, patients with brain damage
  have healed naturally because healthy nerves
  took on the tasks of damaged or destroyed
  nerves, allowing for at least some level of
  functionality.
• There are a variety of mechanisms by
  which neural plasticity can occur; axonal
  sprouting and synaptic pruning are among the
  most common of these mechanisms.
Axonal Sprouting
• In axonal sprouting, healthy axons
  sprout new nerve endings that
  connect to other pathways in the
  nervous system.
• This can be used to strengthen
  existing connections or to repair
  damaged parts of the nervous
  system by repairing damaged
  neural pathways and restoring
  them to full functionality.
Synaptic Pruning
• Following birth, the brain of a
  newborn is flooded with
  information from the baby’s sense
  organs.
• This sensory information must
  somehow make it back to the
  brain where it can be processed.
• To do so, nerve cells must make
  connections with one another,
  transmitting the impulses to the
  brain.
• Over the first few years of life, the brain grows
  rapidly.
• As each neuron matures, it sends out multiple
  branches (axons, which send information out,
  and dendrites, which take in information),
  increasing the number of synaptic contacts and
  laying the specific connections from house to
  house, or in the case of the brain, from neuron
  to neuron.
• At birth, each neuron in the cerebral cortex
  has approximately 2,500 synapses.
• By the time an infant is two or three years old,
  the number of synapses is approximately
  15,000 synapses per neuron (Gopnick, et al.,
  1999).
• This amount is about twice that of the
  average adult brain.
• As we age, old connections are deleted
  through a process called synaptic pruning.
• Synaptic pruning eliminates weaker synaptic
  contacts while stronger connections are kept
  and strengthened.
• Experience determines which connections will
  be strengthened and which will be pruned;
  connections that have been activated most
  frequently are preserved.
• It is plasticity that enables the process of
  developing and pruning connections, allowing
  the brain to adapt itself to its environment.
• Because of axonal sprouting and synaptic
  pruning that lend to neural plasticity, damage to
  the brain or other aspects of the nervous system
  is not always permanent.
• This process is part of what makes humans so
  able to adapt to a broad range of circumstances;
  the very physiology of the brain changes in
  response to a given set of conditions.

  Contrary to common ideas as
  expressed in this diagram, brain
  functions are not confined to
  certain fixed locations.
Network of our Brain
• The communication network in our brain is a
  multi-trillion maze of connections capable of
  performing 20 million-billion calculations per
  second.
• How does this network operate?
• There are three major players:
• Neurons, which power the message,
• Neurotransmitters, which create the message
  and
• Receptors, which receive the message.
• A single one of our neurons can produce
  almost a tenth of a volt, and the total
  electrical activity in our brain is easily
  measurable with an electroencephalogram
  (EEG).
• The impulse then travels at a speed of up to
  150MPH away from the cell body through its
  antennae, the axon.
Neurotransmitters – Chemical Transmission
• Dopamine is the neurotransmitter needed for
  healthy assertiveness and sexual arousal, proper
  immune and autonomic nervous system function.
• Dopamine is important for motivation and a sense
  of readiness to meet life's challenges.
• Age-related cognitive decline is associated with
  dopamine changes in the brain.
• People whose hands tremble from Parkinson's
  disease have a diminished ability to synthesize
  dopamine, which is crucial to fine muscle
  coordination.
• Attention deficits are also connected to dopamine.
• It is one of the most vulnerable key
  neurotransmitters in the brain.
• Dopamine levels are depleted by stress or
  poor sleep.
• Alcohol, caffeine, and sugar all seem to
  diminish dopamine activity in the brain.
• It's also easily oxidized, therefore we should
  eat plenty of fruits and vegetables whose
  antioxidants help protect dopamine-using
  neurons from free radical damage.
• Norepinephrine, also called noradrenalin, is
  the primary excitatory neurotransmitter
  needed for motivation, alertness, and
  concentration.
• A hormone, it travels in the bloodstream to
  arouse brain activity with its adrenalin-like
  effects.
• Our brain requires norepinephrine to form
  new memories and to transfer them to long-
  term storage.
• Both nor-epinephrine and dopamine are
  manufactured from the amino acids
  tyrosine or phenylalanine in the presence
  of adequate oxygen, vitamins B3(Niacin),
  B6(Pyridoxine), and C, folic acid, iron, and
  copper.
• Food sources of tyrosine include
  almonds, avocados, bananas, dairy
  products, lima beans, pumpkin seeds,
  and sesame seeds.
• Serotonin is a calming neurotransmitter
  important to the maintenance of good mood.
• It promotes contentment and is responsible
  for normal sleep.
• In addition to the central nervous system,
  serotonin is also found in the walls of the
  intestine (the enteric nervous system) and in
  platelet cells that promote blood clotting.
• Low serotonin levels produce insomnia and
  depression, aggressive behaviour, increased
  sensitivity to pain, and is associated with
  obsessive-compulsive behaviour and eating
  disorders.
• Serotonin is synthesized from tryptophan in
  the presence of adequate vitamins B1, B3, B6,
  and folic acid.
• The best food sources of tryptophan include
  bananas, brown rice, cottage cheese, meat,
  turkey, spinach, peanuts, and sesame seeds.
• Glutamate and GABA :
• These two are the most common
  neurotransmitters in the brain.
• Glutamate acts on several different types of
  receptors, and have effects that are excitatory
  and modulatory.
• Excessive glutamate can cause neural apoptosis.
• GABA also acts on several different types of
  receptors that are inhibitory.
• GABA is synthesised from glutamate.
• Glutamate rich foods are milk, eggs, meat, fish,
  cheese, soya and walnuts.
• Acetylcholine is the primary chemical carrier
  of thought and memory.
• This excitatory neurotransmitter is essential
  for both the storage and recall of memory, and
  partly responsible for concentration and focus.
• It also plays a significant role in muscular
  coordination.
• A deficit in acetylcholine is directly related to
  memory decline and reduced cognitive
  capacity.
• Its primary building block is choline, which belongs to
  the B family of vitamins and is a fat-like substance that's
  necessary to metabolize fats.
• It is found in lecithin as phosphatidyl choline.
• Foods high in lecithin include egg yolks, wheat germ,
  soybeans, organ meats, and whole wheat products.
• Vitamin C and B5 (Pantothenic acid) are needed for the
  brain to synthesize acetylcholine, in the presence of
  choline acetyl-transferase, a key brain enzyme.
• Acetylcholine levels tend to decline with age, in part
  because of a decreased ability to synthesize this
  enzyme.
Receptors-Open the Doors
• A receptor is essentially a geomagnetic lock
  designed to accept only the right key – the
  neurotransmitter whose molecular shape
  and polarity are a precise fit.
• The typical receptor is a large molecule. The
  exposed section, the 'lily pad,' floats on the
  surface of the cell membrane, while the
  'roots' extend deep into the cell.
• There are as many kinds of
  receptors as there are
  neurotransmitters.
• Receptors are Protein
  molecules.
• Although each receptor is
  supposed to recognize and
  accept only a particular
  neurotransmitter molecule,
  certain medicines and plant
  compounds are also able to
  mate with some receptors.
• Receptors Decline with Age
• The neurotransmitter serotonin interacts with
  at least 15 different receptors in the body.
• After age 20, one of serotonin's most common
  receptors starts to decline in the human brain.
• Receptors for the neurotransmitter dopamine
  also decline with age.
Neurons
• Neurons are the core components of
  the nervous system, which includes
  the brain, spinal cord, and peripheral ganglia.
• Neurons do not undergo cell division.
• In most cases, neurons are generated by
  special types of stem cells.
• Astrocytes, a type of glial cell, have been
  observed to turn into neurons by virtue of the
  stem cell characteristic pluripotency.
• This is called “recruitment.”
• The key to neural function is the synaptic signalling
  process, which is partly electrical and partly
  chemical.
• The electrical aspect depends on properties of the
  neuron's membrane.
• Every neuron is surrounded by a plasma
  membrane, a bilayer of lipid molecules with many
  types of protein structures embedded in it.
• To build brain cells we need fatty acids.
• A lipid layer also coats the axon (Myelin), acting as
  insulation for electrical impulses.
• One of the most common fatty acids in myelin is
  oleic acid, which is also the most abundant fatty
  acid in human milk.
• From ALA and LA, the 2 essential FAs, our
  brain can make (docosahexaenoic acid) DHA
  and (arachidonic acid) AA, the longer chained
  fatty acids that are incorporated in its cell
  membranes.
• The brain's ability to assemble these fatty
  acids can be compromised by stress,
  infections, alcohol, excess sugar, and vitamin
  or mineral deficiencies – factors common
  today.
• Also, the oxidative damage that comes with
  age causes a decline in membrane DHA
  concentrations, and with it, cognitive
  impairment.
• Essential Fatty Acids have been shown to
  actually boost intelligence and an imbalance
  of fatty acids may be linked to hyperactivity,
  depression, brain allergies, and schizophrenia.
Blood Vessels
• Any discussion of the brain must include the
  vast network of blood vessels that serve it.
• There are 400 miles of capillaries in the human
  brain having a surface area of approximately
  100 square feet.
• And, the health of these vessel walls is
  paramount to proper brain function. Hence
  avoidance of trans fats.
• Not only is the bloodstream a river of life
  constantly delivering oxygen, glucose, and
  nutrients to the brain – and removing toxins –
  it also cools the brain.
• One of the bloodstream's important functions
  is to keep brain cells from overheating.
History
• During most of the 20th century, the
  general consensus among neuroscientists
  was that brain structure is relatively
  immutable after a critical period during
  early childhood.

• This belief has been challenged by findings
  revealing that many aspects of the brain
  remain plastic even into adulthood
• In 1793, Italian anatomist Michele Vicenzo
  Malacarne described experiments in which he
  paired animals, trained one of the pair
  extensively for years, and then dissected both.
• He discovered that the cerebellums of the
  trained animals were substantially larger.
• But, these findings were eventually forgotten.
• The first person to use the term neural
  plasticity appears to have been the Polish
  neuroscientist Jerzy Konorski.
• A tragic stroke that left his father paralyzed
  inspired Prof. Paul Bach-y-Rita, an American
  neuroscientist, to study brain rehabilitation.
• His brother, a physician, worked tirelessly to
  develop therapeutic measures which were so
  successful that the father recovered complete
  functionality by age 68 and was able to live a
  normal, active life which even included mountain
  climbing.
• "His father’s story was first hand evidence that a
  ‘late recovery’ could occur even with a massive
  lesion in an elderly person.
Phantom limbs
• The experience of Phantom limbs is a
  phenomenon in which a person continues to
  feel pain or sensation within a part of their
  body which has been amputated.
• This is strangely common, occurring in 60-
  80% of amputees.
• An explanation for this refers to the concept of
  neuroplasticity, as the cortical maps of the
  removed limbs are believed to have become
  engaged with the area around them in
  the post-central gyrus (sensory cortex).
• This results in activity within the surrounding
  area of the cortex being misinterpreted by the
  area of the cortex formerly responsible for the
  amputated limb.
• In the early 1990s V.S. Ramachandran
  theorized that phantom limbs were the result
  of cortical remapping.
• However, cortical remapping occurs only in
  patients who have phantom pain.
• Research showed that phantom limb pain
  (rather than referred sensations) was the
  perceptual correlate of cortical reorganization.
• This phenomenon is sometimes referred to as
  maladaptive plasticity.
A diagrammatic explanation of the
                 mirror box.
• The patient places the good limb
   into one side of the box (in this
   case the right hand) and the
   amputated limb into the other
   side.
• Due to the mirror, the patient
   sees a reflection of the good
   hand where the missing limb
   would be.
• The patient thus receives
   artificial visual feedback that the
   "resurrected" limb is now moving
   when they move the good hand.
• In 2009 Lorimer Moseley and Peter Brugger
  carried out a remarkable experiment in which
  they encouraged arm amputee subjects to use
  visual imagery to contort their phantom limbs
  into impossible configurations.
• Four of the seven subjects succeeded (as
  recorded on fMRI scans).
• This experiment suggests that nerves can still
  be used to execute impossible movements in
  the absence of feedback from the body: “the
  brain truly does change itself."
Thinking About Thinking
• As scientists probe the limits of neuroplasticity,
  they are finding that mind sculpting can occur
  even without input from the outside world.
• The brain can change as a result of the thoughts
  we think.
• This has important implications for health:
  thought can affect the very stuff of the brain,
  altering neuronal connections in a way that can
  treat mental illness or, perhaps, lead to a greater
  capacity for empathy and compassion.
• It may even dial up the supposedly immovable
  happiness set point!
• In a series of experiments, Jeffrey Schwartz
  and colleagues at the University of
  California, Los Angeles, found that cognitive
  behavior therapy (CBT) can quiet activity in
  the circuit that underlies obsessive-
  compulsive disorder (OCD), just as drugs do.
• Schwartz had become intrigued with the
  therapeutic potential of mindfulness
  meditation, the Buddhist practice of
  observing one's inner experiences as if they
  were happening to someone else.
• When OCD patients were plagued by an obsessive
  thought, Schwartz instructed them to think, "My
  brain is generating another obsessive thought
  thrown up by a faulty circuit."
• After 10 weeks of mindfulness-based therapy, 12
  out of 18 patients improved significantly.
• Before-and-after brain scans showed that activity
  in the orbital frontal cortex, the core of the OCD
  circuit, had fallen dramatically and in exactly the
  way that drugs against OCD affect the brain.
• Schwartz called it "self-directed neuroplasticity,"
  concluding that "the mind can change the brain."
Plasticity of Learning and Memory
• Learning, as defined by Tortora and Grabowski
  (1996), is the ability to acquire new knowledge
  or skills through instruction or experience.
• Initially, newly learned data are "stored" in
  short-term memory, which is a temporary
  ability to recall a few pieces of information
• After a period of time, information may be
  moved into a more permanent type of memory,
  long-term memory, which is the result of
  anatomical or biochemical changes that occur in
  the brain.
• The human brain now faces a challenge never
  before encountered in its thousands of
  generations of development. Modern food
  processing techniques have actually altered a
  basic building block of the brain.
• Trans fatty acids found in foods disrupt
  communication in our brain. By modifying
  natural fats, we have altered the basic building
  blocks of the human brain – weakening the
  brain’s architecture.
Factors that control neurogenesis:
• Experiences:
• Enriched environment increases promotion of
  cell survival
• Exercise increases rate of cell division
• Learning tasks increase synapse formation
• Stress reduces neurochemicals
• Growth factors increase: Epidermal growth
  factor favours differentiation into glial cells,
  whereas fibroblasts growth factors promote
  neuronal production.
• Serotonin increases axonal sprouting and
  synapse formation.
• Estrogen, testosterone increases brain
  neurotropic hormones.
• Glucocorticoids (stress) reduce synapse
  formation and axonal sprouting. Chronic stress
  can reduce the number of dendritic spines
• Damage: Epileptic seizures and Stroke cause
  permanent nerve tissue damage but also
  stimulate an increase in nerve regeneration.
• Genetics
Injury-induced
    Plasticity: Brain Repair
• During brain repair following injury, plastic
  changes are geared towards maximizing
  function in spite of the damaged brain (animal
  studies).
• Although this phenomenon has not been
  widely studied in humans, data indicate that
  changes occur in human brains following injury.
• An important aspect of neuroplasticity
  involves the monitoring of neurotransmitter
  activities.
• Specific receptors help neurons sense the
  environment and turn the genes which cause
  production of neurotransmitters and their
  receptors on or off.
• For example, if an individual has just
  experienced a stressful situation, the brain
  senses the rise in stress level and may turn off
  or turn down the genes that make
  neurotransmitter receptors.
• Acute and chronic stress can
  have quite different effects
  on learning:
• Acute stress can potentiate
  learning ( Shors, 2001),
• Chronic stress leads to
  deficits in hippocampus-
  dependent memory
  reminiscent of those seen in
  major depression.
Neuroplasticity and Depression
• Evidence has accumulated that structural
  changes in the limbic system may be related
  to major depression.
• Duman suggests that major depression and
  other affective disorders could result in loss of
  neuroplasticity.
• Scientists at the University of Toronto had 14
  depressed adults undergo CBT, which teaches
  patients to view their own thoughts differently--
  to see a failed date, for instance, not as proof
  that "I will never be loved" but as a minor thing
  that didn't work out.
• Thirteen other patients received paroxetine (the
  generic form of the antidepressant Paxil).
• All experienced comparable improvement after
  treatment.
• Then the scientists scanned the patients' brains.
• Surprise !
• Depressed brains responded differently to the
  two kinds of treatment--and in a very
  interesting way.
• CBT muted overactivity in the frontal cortex,
  the seat of reasoning, logic and higher thought.
• Paroxetine, by contrast, raised activity there.
• CBT raised activity in the hippocampus of the
  limbic system, the brain's emotion center.
• Paroxetine lowered activity there.
Happiness and Meditation
• Could thinking about thoughts in a new way
  affect not only such pathological brain states
  as OCD and depression but also normal
  activity?
• To find out, neuroscientist Richard Davidson of
  the University of Wisconsin at Madison turned
  to Buddhist monks, the Olympic athletes of
  mental training.
• Some monks have spent more than 10,000
  hours of their lives in meditation
• During the generation of pure compassion,
  brain regions that keep track of what is self and
  what is other became quieter, fMRI showed, as
  if the subjects opened their minds and hearts
  to others.
• Connections from the frontal regions, so active
  during compassion meditation, to the brain's
  emotional regions seemed to become stronger
  with more years of meditation practice.
• But perhaps the most striking difference was
  in an area in the left prefrontal cortex--the
  site of activity that marks happiness.
• While the monks were generating feelings of
  compassion, activity in the left prefrontal
  swamped activity in the right prefrontal
  (associated with negative moods) to a degree
  never seen from purely mental activity.
• For the monks as well as the patients with
  depression or OCD, the conscious act of
  thinking about their thoughts in a particular
  way rearranged the brain.
How the Brain is Mapped
• Positron Emission Tomography (PET) allows
  scientists to determine the metabolic rates of
  the brain by measuring oxygen and blood
  sugar (glucose) utilization.
• Areas of the brain that are active use more
  oxygen and glucose than areas that are not
  active.
• Functional MRI (fMRI) also
  allows us to determine which
  parts of the brain are active.
• fMRI measures blood flow.
  Magnets in the fMRI scanner
  exploit the natural magnetic
  properties of blood and water in
  the body, and create a color-
  coded image on a computer
  screen.
• The fMRI image informs
  researchers which areas of the
  brain have the highest (more
  activity) and lowest (low activity)
  blood flows.
• The prefrontal cortex enables us to regulate
  emotions, and more specifically, helps us inhibit
  inappropriate or incapacitating emotions.
• If our left prefrontal cortex is less active, then
  negative emotions (such as depressed mood) may
  be expressed more frequently and more
  intensely.
• An active Left PC indicates a happy mood.
“Brainswitching”
The use of simple repetitive mind exercises can
  switch the neural activity from the emotional
  part of the brain (the subcortex – limbic
  system), where sadness originates, to the
  thinking part of the brain (the neocortex) which
  does not have the capacity for depression.
• Here's an example of an exercise.
• If you wake up depressed, instead of thinking
  "I'm so depressed," think some neutral or
  nonsense thought over and over, repetitively,
  like "green frog, green frog" or "yes, yes, yes,
  yes," or sing a nursery rhyme to yourself like
  "Row, row, row, your boat."
• Scream it in your mind if you have to.
• Concentrate on the phrase you have chosen.
• Refuse to think the thought "I am depressed."
• This switch in neural brain activity from the
  subcortex to the neocortex happens naturally,
  sooner or later, even in the worst cases of
  depression.
• This is the reason depression is cyclical.
• But brainswitching accomplishes the switch
  as an act of will and a lot more quickly than
  waiting for nature to take its course.
• Depression is like living in a room of pain.
• With brainswitching you can learn how to
  leave the room.
FRS factor
• The Feelings Receptor Station in the
  neocortex is where signals from the
  emotional part of the brain (the subcortex)
  must travel upwards and be acknowledged in
  the thinking part of the brain (the neocortex)
  before a human being is able to feel any pain
  or emotion.
• The FRS factor is why a player can break a
  bone during a football game and not feel any
  pain until the game is over.
• His neocortical concentration on the game
  has jammed the acknowledgment in the
  neocortex that pain is being produced in the
  subcortes.
• The limitation of the human attention span
  is the scientific basis for mind modulation.
• The mind can only concentrate on one
  thought at a time and you can think any
  thought you want.
• More specifically, when two targets T1 and T2
  are embedded in a rapid stream of events,
  and presented in close temporal proximity,
  the second target is often not seen.
• When many resources are devoted to T1
  processing, too few may be available for
  subsequent T2 processing (the magician –
  rabbit experiment)
• This is the basis of mindfulness meditation
  and MBSR.
Psychoneuroimmunology
• Psychoneuroimmunology is a specialized
  field of research that studies the
  interactions between the brain,
  psychology, and the immune system.
• This field primarily centres on our body's
  reaction to stress.
• In humans, chronic stress seems to influence the
  serotonin, norepinephrine, and dopamine
  neurotransmitter systems, particularly in
  individuals who are socially isolated and/or have
  poor coping skills.
• Stress also causes a decline in the rate of
  formation of new neurons (neurogenesis) in the
  part of the brain known as the hippocampus.
• Autopsy evidence suggests that depressed people
  who experienced chronic stress and then went on
  to commit suicide showed reduced neurogenesis
  in the hippocampus
CAM in Neuromodulation
• St. John's Wort has been used for
  thousands of years, and is currently one
  of the top selling herbs for depression.
• There are many active chemical
  constituents in St. John's Wort.
• These chemicals, called hypericin,
  pseudohypericin, and hyperforin, have all
  been investigated for their anti-
  depressant properties.
• Exercising as little as three hours a week can have
  a profound effect on the symptoms of depression.
• Researchers are puzzled about the exact reason
  for the benefits, but studies conducted with
  animals suggest that exercise increases serotonin,
  dopamine and norepinephrine levels.
• Exercise also releases endorphins, chemicals
  naturally produced in the body, which reduce the
  experience of pain and enhance neuroplasticity,
  thus improving mood, learning capacity and
  memory.
• Omega-3 Fatty Acids (oils), which include
  eicosapentaenoic acid (EPA) and
  docosahexaenoic acid (DHA), are found
  primarily in fish (such as mackerel, lake trout,
  herring, sardines, albacore tuna, and salmon)
  and some plants.
• There is strong evidence from epidemiological
  (population) studies that cultures which eat
  large amounts of fish containing these oils
  have a low incidence of depression,
  Alzheimer’s and stress disorders.
• SAMe (pronounced "Sammy") stands for S-
  adenosyl-L-methionine. SAMe is a compound
  produced by the liver and used throughout the
  body in a chemical process called methylation.
• Because there are no foods that have high SAMe
  levels, our bodies must make this substance.
• Our liver usually creates SAMe from the amino
  acid methionine, which is found in many foods,
  with the help of vitamin B12 and folate.
• The brain use of SAMe is in the creation of the
  neurotransmitters dopamine, serotonin and
  norepinephrine.
• 5-hydoxytryptophan (5-HTP) is a compound made
  from the amino acid (protein) tryptophan and is
  primarily found in the brain.
• 5-HTP is one of the basic building blocks for
  serotonin.
• Serotonin itself can be manufactured in the
  laboratory, but when taken as a supplement, it
  cannot reach the brain .
• Multiple research studies support the use of 5-
  HTP as a natural way to increase brain serotonin
  levels.
• Tryptophan rich foods are milk, bananas, spinach
  and turkey.
• B-vitamins, especially B1 (thiamin), B6
  (pyridoxine), B9 (folic acid), and B12
  (cobalamin) have all been examined for their
  contribution to neural plasticity.

• These B-vitamins play many important roles in
  the body and are necessary for the
  manufacture of GABA, serotonin, dopamine,
  and other neurotransmitters responsible for
  regulating mood.
• Acupuncture balances yin and yang, keeps the
  normal flow of energy unblocked, and restores
  health to the body and mind.
• A Western interpretation of acupuncture is
  that the treatment stimulates the central
  nervous system, releasing chemicals into the
  muscles, spinal cord, and brain, promoting the
  body's natural healing abilities.
• Acupuncture may also alter brain chemistry by
  changing the release of neurotransmitters and
  hormones that positively impact mood.
Meditation
• Meditation was conceptualized as a family of
  complex emotional and attentional
  regulatory strategies developed for various
  ends, including the cultivation of well-being
  and emotional balance.
• There are two common styles of meditation,
  i.e.,
1. Focused attention (FA) meditation and
2. Open monitoring (OM) meditation.
• FA meditation entails voluntarily focusing
  attention on a chosen object in a sustained
  fashion.

• OM meditation involves non-reactively
  monitoring the content of experience from
  moment to moment, primarily as a means to
  recognize the nature of emotional and
  cognitive patterns.
• OM meditation initially involves the use of FA
  training to calm the mind and reduce
  distractions, but as FA advances, the cultivation
  of the monitoring skill per se becomes the
  main focus of practice.

• The aim is to reach a state in which no explicit
  focus on a specific object is retained; instead,
  one remains only in the monitoring state,
  attentive moment by moment to anything that
  occurs in experience.
The Take-away



• Our brains have the lifelong ability to adapt
  and build.
• It's true! No matter how old we get, our brains
  are always finding new and better ways to
  reorganize neural pathways (information
  highways, if you will) and even build brand new
  ones.
• These neural "information highways" form the
  basis of our cognitive skills.
• Cognitive skills not only make up IQ, they also
  determine how efficiently we're able to process
  information in every area of our lives.
• No matter how old we get, our mental abilities
  (and even IQ!) are never "set in stone."
• Because the brain is always adapting and building,
  our ability to think, remember and learn is never
  static— it can always be upgraded and improved!
Q?
Thank you

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Neuroplasticity Tutorial: How Your Brain Changes Throughout Life

  • 1. Neuroplasticity Tutorial By: Dr Madhumita Sen
  • 2. Introduction • What is brain plasticity? • Does it mean that our brains are made of plastic? • Of course not! • Plasticity, or neuroplasticity, is the lifelong ability of the brain to reorganize neural pathways based on new experiences. • As we learn, we acquire new knowledge and skills through instruction or experience
  • 3. • Definition: Neural plasticity, which is also known as neuroplasticity, brain plasticity, cortical plasticity, is the changing of the structure, function, and organization of neurons in response to new experiences. • Neural plasticity specifically refers to strengthening or weakening nerve connections or adding new nerve cells based on outside experiences.
  • 5. • In some cases, patients with brain damage have healed naturally because healthy nerves took on the tasks of damaged or destroyed nerves, allowing for at least some level of functionality. • There are a variety of mechanisms by which neural plasticity can occur; axonal sprouting and synaptic pruning are among the most common of these mechanisms.
  • 6. Axonal Sprouting • In axonal sprouting, healthy axons sprout new nerve endings that connect to other pathways in the nervous system. • This can be used to strengthen existing connections or to repair damaged parts of the nervous system by repairing damaged neural pathways and restoring them to full functionality.
  • 7. Synaptic Pruning • Following birth, the brain of a newborn is flooded with information from the baby’s sense organs. • This sensory information must somehow make it back to the brain where it can be processed. • To do so, nerve cells must make connections with one another, transmitting the impulses to the brain.
  • 8. • Over the first few years of life, the brain grows rapidly. • As each neuron matures, it sends out multiple branches (axons, which send information out, and dendrites, which take in information), increasing the number of synaptic contacts and laying the specific connections from house to house, or in the case of the brain, from neuron to neuron.
  • 9. • At birth, each neuron in the cerebral cortex has approximately 2,500 synapses. • By the time an infant is two or three years old, the number of synapses is approximately 15,000 synapses per neuron (Gopnick, et al., 1999). • This amount is about twice that of the average adult brain. • As we age, old connections are deleted through a process called synaptic pruning.
  • 10. • Synaptic pruning eliminates weaker synaptic contacts while stronger connections are kept and strengthened. • Experience determines which connections will be strengthened and which will be pruned; connections that have been activated most frequently are preserved. • It is plasticity that enables the process of developing and pruning connections, allowing the brain to adapt itself to its environment.
  • 11. • Because of axonal sprouting and synaptic pruning that lend to neural plasticity, damage to the brain or other aspects of the nervous system is not always permanent. • This process is part of what makes humans so able to adapt to a broad range of circumstances; the very physiology of the brain changes in response to a given set of conditions. Contrary to common ideas as expressed in this diagram, brain functions are not confined to certain fixed locations.
  • 12. Network of our Brain • The communication network in our brain is a multi-trillion maze of connections capable of performing 20 million-billion calculations per second. • How does this network operate? • There are three major players: • Neurons, which power the message, • Neurotransmitters, which create the message and • Receptors, which receive the message.
  • 13. • A single one of our neurons can produce almost a tenth of a volt, and the total electrical activity in our brain is easily measurable with an electroencephalogram (EEG). • The impulse then travels at a speed of up to 150MPH away from the cell body through its antennae, the axon.
  • 14. Neurotransmitters – Chemical Transmission • Dopamine is the neurotransmitter needed for healthy assertiveness and sexual arousal, proper immune and autonomic nervous system function. • Dopamine is important for motivation and a sense of readiness to meet life's challenges. • Age-related cognitive decline is associated with dopamine changes in the brain. • People whose hands tremble from Parkinson's disease have a diminished ability to synthesize dopamine, which is crucial to fine muscle coordination. • Attention deficits are also connected to dopamine.
  • 15. • It is one of the most vulnerable key neurotransmitters in the brain. • Dopamine levels are depleted by stress or poor sleep. • Alcohol, caffeine, and sugar all seem to diminish dopamine activity in the brain. • It's also easily oxidized, therefore we should eat plenty of fruits and vegetables whose antioxidants help protect dopamine-using neurons from free radical damage.
  • 16. • Norepinephrine, also called noradrenalin, is the primary excitatory neurotransmitter needed for motivation, alertness, and concentration. • A hormone, it travels in the bloodstream to arouse brain activity with its adrenalin-like effects. • Our brain requires norepinephrine to form new memories and to transfer them to long- term storage.
  • 17. • Both nor-epinephrine and dopamine are manufactured from the amino acids tyrosine or phenylalanine in the presence of adequate oxygen, vitamins B3(Niacin), B6(Pyridoxine), and C, folic acid, iron, and copper. • Food sources of tyrosine include almonds, avocados, bananas, dairy products, lima beans, pumpkin seeds, and sesame seeds.
  • 18. • Serotonin is a calming neurotransmitter important to the maintenance of good mood. • It promotes contentment and is responsible for normal sleep. • In addition to the central nervous system, serotonin is also found in the walls of the intestine (the enteric nervous system) and in platelet cells that promote blood clotting.
  • 19. • Low serotonin levels produce insomnia and depression, aggressive behaviour, increased sensitivity to pain, and is associated with obsessive-compulsive behaviour and eating disorders. • Serotonin is synthesized from tryptophan in the presence of adequate vitamins B1, B3, B6, and folic acid. • The best food sources of tryptophan include bananas, brown rice, cottage cheese, meat, turkey, spinach, peanuts, and sesame seeds.
  • 20. • Glutamate and GABA : • These two are the most common neurotransmitters in the brain. • Glutamate acts on several different types of receptors, and have effects that are excitatory and modulatory. • Excessive glutamate can cause neural apoptosis. • GABA also acts on several different types of receptors that are inhibitory. • GABA is synthesised from glutamate. • Glutamate rich foods are milk, eggs, meat, fish, cheese, soya and walnuts.
  • 21. • Acetylcholine is the primary chemical carrier of thought and memory. • This excitatory neurotransmitter is essential for both the storage and recall of memory, and partly responsible for concentration and focus. • It also plays a significant role in muscular coordination. • A deficit in acetylcholine is directly related to memory decline and reduced cognitive capacity.
  • 22. • Its primary building block is choline, which belongs to the B family of vitamins and is a fat-like substance that's necessary to metabolize fats. • It is found in lecithin as phosphatidyl choline. • Foods high in lecithin include egg yolks, wheat germ, soybeans, organ meats, and whole wheat products. • Vitamin C and B5 (Pantothenic acid) are needed for the brain to synthesize acetylcholine, in the presence of choline acetyl-transferase, a key brain enzyme. • Acetylcholine levels tend to decline with age, in part because of a decreased ability to synthesize this enzyme.
  • 23. Receptors-Open the Doors • A receptor is essentially a geomagnetic lock designed to accept only the right key – the neurotransmitter whose molecular shape and polarity are a precise fit. • The typical receptor is a large molecule. The exposed section, the 'lily pad,' floats on the surface of the cell membrane, while the 'roots' extend deep into the cell.
  • 24. • There are as many kinds of receptors as there are neurotransmitters. • Receptors are Protein molecules. • Although each receptor is supposed to recognize and accept only a particular neurotransmitter molecule, certain medicines and plant compounds are also able to mate with some receptors.
  • 25. • Receptors Decline with Age • The neurotransmitter serotonin interacts with at least 15 different receptors in the body. • After age 20, one of serotonin's most common receptors starts to decline in the human brain. • Receptors for the neurotransmitter dopamine also decline with age.
  • 26. Neurons • Neurons are the core components of the nervous system, which includes the brain, spinal cord, and peripheral ganglia. • Neurons do not undergo cell division. • In most cases, neurons are generated by special types of stem cells. • Astrocytes, a type of glial cell, have been observed to turn into neurons by virtue of the stem cell characteristic pluripotency. • This is called “recruitment.”
  • 27. • The key to neural function is the synaptic signalling process, which is partly electrical and partly chemical. • The electrical aspect depends on properties of the neuron's membrane. • Every neuron is surrounded by a plasma membrane, a bilayer of lipid molecules with many types of protein structures embedded in it. • To build brain cells we need fatty acids. • A lipid layer also coats the axon (Myelin), acting as insulation for electrical impulses. • One of the most common fatty acids in myelin is oleic acid, which is also the most abundant fatty acid in human milk.
  • 28. • From ALA and LA, the 2 essential FAs, our brain can make (docosahexaenoic acid) DHA and (arachidonic acid) AA, the longer chained fatty acids that are incorporated in its cell membranes. • The brain's ability to assemble these fatty acids can be compromised by stress, infections, alcohol, excess sugar, and vitamin or mineral deficiencies – factors common today.
  • 29. • Also, the oxidative damage that comes with age causes a decline in membrane DHA concentrations, and with it, cognitive impairment. • Essential Fatty Acids have been shown to actually boost intelligence and an imbalance of fatty acids may be linked to hyperactivity, depression, brain allergies, and schizophrenia.
  • 30. Blood Vessels • Any discussion of the brain must include the vast network of blood vessels that serve it. • There are 400 miles of capillaries in the human brain having a surface area of approximately 100 square feet. • And, the health of these vessel walls is paramount to proper brain function. Hence avoidance of trans fats.
  • 31. • Not only is the bloodstream a river of life constantly delivering oxygen, glucose, and nutrients to the brain – and removing toxins – it also cools the brain. • One of the bloodstream's important functions is to keep brain cells from overheating.
  • 32. History • During most of the 20th century, the general consensus among neuroscientists was that brain structure is relatively immutable after a critical period during early childhood. • This belief has been challenged by findings revealing that many aspects of the brain remain plastic even into adulthood
  • 33. • In 1793, Italian anatomist Michele Vicenzo Malacarne described experiments in which he paired animals, trained one of the pair extensively for years, and then dissected both. • He discovered that the cerebellums of the trained animals were substantially larger. • But, these findings were eventually forgotten. • The first person to use the term neural plasticity appears to have been the Polish neuroscientist Jerzy Konorski.
  • 34. • A tragic stroke that left his father paralyzed inspired Prof. Paul Bach-y-Rita, an American neuroscientist, to study brain rehabilitation. • His brother, a physician, worked tirelessly to develop therapeutic measures which were so successful that the father recovered complete functionality by age 68 and was able to live a normal, active life which even included mountain climbing. • "His father’s story was first hand evidence that a ‘late recovery’ could occur even with a massive lesion in an elderly person.
  • 35. Phantom limbs • The experience of Phantom limbs is a phenomenon in which a person continues to feel pain or sensation within a part of their body which has been amputated. • This is strangely common, occurring in 60- 80% of amputees.
  • 36. • An explanation for this refers to the concept of neuroplasticity, as the cortical maps of the removed limbs are believed to have become engaged with the area around them in the post-central gyrus (sensory cortex). • This results in activity within the surrounding area of the cortex being misinterpreted by the area of the cortex formerly responsible for the amputated limb.
  • 37. • In the early 1990s V.S. Ramachandran theorized that phantom limbs were the result of cortical remapping. • However, cortical remapping occurs only in patients who have phantom pain. • Research showed that phantom limb pain (rather than referred sensations) was the perceptual correlate of cortical reorganization. • This phenomenon is sometimes referred to as maladaptive plasticity.
  • 38. A diagrammatic explanation of the mirror box. • The patient places the good limb into one side of the box (in this case the right hand) and the amputated limb into the other side. • Due to the mirror, the patient sees a reflection of the good hand where the missing limb would be. • The patient thus receives artificial visual feedback that the "resurrected" limb is now moving when they move the good hand.
  • 39. • In 2009 Lorimer Moseley and Peter Brugger carried out a remarkable experiment in which they encouraged arm amputee subjects to use visual imagery to contort their phantom limbs into impossible configurations. • Four of the seven subjects succeeded (as recorded on fMRI scans). • This experiment suggests that nerves can still be used to execute impossible movements in the absence of feedback from the body: “the brain truly does change itself."
  • 40. Thinking About Thinking • As scientists probe the limits of neuroplasticity, they are finding that mind sculpting can occur even without input from the outside world. • The brain can change as a result of the thoughts we think. • This has important implications for health: thought can affect the very stuff of the brain, altering neuronal connections in a way that can treat mental illness or, perhaps, lead to a greater capacity for empathy and compassion. • It may even dial up the supposedly immovable happiness set point!
  • 41. • In a series of experiments, Jeffrey Schwartz and colleagues at the University of California, Los Angeles, found that cognitive behavior therapy (CBT) can quiet activity in the circuit that underlies obsessive- compulsive disorder (OCD), just as drugs do. • Schwartz had become intrigued with the therapeutic potential of mindfulness meditation, the Buddhist practice of observing one's inner experiences as if they were happening to someone else.
  • 42. • When OCD patients were plagued by an obsessive thought, Schwartz instructed them to think, "My brain is generating another obsessive thought thrown up by a faulty circuit." • After 10 weeks of mindfulness-based therapy, 12 out of 18 patients improved significantly. • Before-and-after brain scans showed that activity in the orbital frontal cortex, the core of the OCD circuit, had fallen dramatically and in exactly the way that drugs against OCD affect the brain. • Schwartz called it "self-directed neuroplasticity," concluding that "the mind can change the brain."
  • 43. Plasticity of Learning and Memory • Learning, as defined by Tortora and Grabowski (1996), is the ability to acquire new knowledge or skills through instruction or experience. • Initially, newly learned data are "stored" in short-term memory, which is a temporary ability to recall a few pieces of information • After a period of time, information may be moved into a more permanent type of memory, long-term memory, which is the result of anatomical or biochemical changes that occur in the brain.
  • 44. • The human brain now faces a challenge never before encountered in its thousands of generations of development. Modern food processing techniques have actually altered a basic building block of the brain. • Trans fatty acids found in foods disrupt communication in our brain. By modifying natural fats, we have altered the basic building blocks of the human brain – weakening the brain’s architecture.
  • 45. Factors that control neurogenesis: • Experiences: • Enriched environment increases promotion of cell survival • Exercise increases rate of cell division • Learning tasks increase synapse formation • Stress reduces neurochemicals • Growth factors increase: Epidermal growth factor favours differentiation into glial cells, whereas fibroblasts growth factors promote neuronal production.
  • 46. • Serotonin increases axonal sprouting and synapse formation. • Estrogen, testosterone increases brain neurotropic hormones. • Glucocorticoids (stress) reduce synapse formation and axonal sprouting. Chronic stress can reduce the number of dendritic spines • Damage: Epileptic seizures and Stroke cause permanent nerve tissue damage but also stimulate an increase in nerve regeneration. • Genetics
  • 47. Injury-induced Plasticity: Brain Repair • During brain repair following injury, plastic changes are geared towards maximizing function in spite of the damaged brain (animal studies). • Although this phenomenon has not been widely studied in humans, data indicate that changes occur in human brains following injury.
  • 48. • An important aspect of neuroplasticity involves the monitoring of neurotransmitter activities. • Specific receptors help neurons sense the environment and turn the genes which cause production of neurotransmitters and their receptors on or off. • For example, if an individual has just experienced a stressful situation, the brain senses the rise in stress level and may turn off or turn down the genes that make neurotransmitter receptors.
  • 49. • Acute and chronic stress can have quite different effects on learning: • Acute stress can potentiate learning ( Shors, 2001), • Chronic stress leads to deficits in hippocampus- dependent memory reminiscent of those seen in major depression.
  • 50. Neuroplasticity and Depression • Evidence has accumulated that structural changes in the limbic system may be related to major depression. • Duman suggests that major depression and other affective disorders could result in loss of neuroplasticity.
  • 51. • Scientists at the University of Toronto had 14 depressed adults undergo CBT, which teaches patients to view their own thoughts differently-- to see a failed date, for instance, not as proof that "I will never be loved" but as a minor thing that didn't work out. • Thirteen other patients received paroxetine (the generic form of the antidepressant Paxil). • All experienced comparable improvement after treatment. • Then the scientists scanned the patients' brains.
  • 52. • Surprise ! • Depressed brains responded differently to the two kinds of treatment--and in a very interesting way. • CBT muted overactivity in the frontal cortex, the seat of reasoning, logic and higher thought. • Paroxetine, by contrast, raised activity there. • CBT raised activity in the hippocampus of the limbic system, the brain's emotion center. • Paroxetine lowered activity there.
  • 53. Happiness and Meditation • Could thinking about thoughts in a new way affect not only such pathological brain states as OCD and depression but also normal activity? • To find out, neuroscientist Richard Davidson of the University of Wisconsin at Madison turned to Buddhist monks, the Olympic athletes of mental training. • Some monks have spent more than 10,000 hours of their lives in meditation
  • 54. • During the generation of pure compassion, brain regions that keep track of what is self and what is other became quieter, fMRI showed, as if the subjects opened their minds and hearts to others. • Connections from the frontal regions, so active during compassion meditation, to the brain's emotional regions seemed to become stronger with more years of meditation practice.
  • 55. • But perhaps the most striking difference was in an area in the left prefrontal cortex--the site of activity that marks happiness. • While the monks were generating feelings of compassion, activity in the left prefrontal swamped activity in the right prefrontal (associated with negative moods) to a degree never seen from purely mental activity. • For the monks as well as the patients with depression or OCD, the conscious act of thinking about their thoughts in a particular way rearranged the brain.
  • 56. How the Brain is Mapped • Positron Emission Tomography (PET) allows scientists to determine the metabolic rates of the brain by measuring oxygen and blood sugar (glucose) utilization. • Areas of the brain that are active use more oxygen and glucose than areas that are not active.
  • 57. • Functional MRI (fMRI) also allows us to determine which parts of the brain are active. • fMRI measures blood flow. Magnets in the fMRI scanner exploit the natural magnetic properties of blood and water in the body, and create a color- coded image on a computer screen. • The fMRI image informs researchers which areas of the brain have the highest (more activity) and lowest (low activity) blood flows.
  • 58. • The prefrontal cortex enables us to regulate emotions, and more specifically, helps us inhibit inappropriate or incapacitating emotions. • If our left prefrontal cortex is less active, then negative emotions (such as depressed mood) may be expressed more frequently and more intensely. • An active Left PC indicates a happy mood.
  • 59. “Brainswitching” The use of simple repetitive mind exercises can switch the neural activity from the emotional part of the brain (the subcortex – limbic system), where sadness originates, to the thinking part of the brain (the neocortex) which does not have the capacity for depression.
  • 60. • Here's an example of an exercise. • If you wake up depressed, instead of thinking "I'm so depressed," think some neutral or nonsense thought over and over, repetitively, like "green frog, green frog" or "yes, yes, yes, yes," or sing a nursery rhyme to yourself like "Row, row, row, your boat." • Scream it in your mind if you have to. • Concentrate on the phrase you have chosen. • Refuse to think the thought "I am depressed."
  • 61. • This switch in neural brain activity from the subcortex to the neocortex happens naturally, sooner or later, even in the worst cases of depression. • This is the reason depression is cyclical. • But brainswitching accomplishes the switch as an act of will and a lot more quickly than waiting for nature to take its course. • Depression is like living in a room of pain. • With brainswitching you can learn how to leave the room.
  • 62. FRS factor • The Feelings Receptor Station in the neocortex is where signals from the emotional part of the brain (the subcortex) must travel upwards and be acknowledged in the thinking part of the brain (the neocortex) before a human being is able to feel any pain or emotion. • The FRS factor is why a player can break a bone during a football game and not feel any pain until the game is over.
  • 63. • His neocortical concentration on the game has jammed the acknowledgment in the neocortex that pain is being produced in the subcortes. • The limitation of the human attention span is the scientific basis for mind modulation. • The mind can only concentrate on one thought at a time and you can think any thought you want.
  • 64. • More specifically, when two targets T1 and T2 are embedded in a rapid stream of events, and presented in close temporal proximity, the second target is often not seen. • When many resources are devoted to T1 processing, too few may be available for subsequent T2 processing (the magician – rabbit experiment) • This is the basis of mindfulness meditation and MBSR.
  • 65. Psychoneuroimmunology • Psychoneuroimmunology is a specialized field of research that studies the interactions between the brain, psychology, and the immune system. • This field primarily centres on our body's reaction to stress.
  • 66. • In humans, chronic stress seems to influence the serotonin, norepinephrine, and dopamine neurotransmitter systems, particularly in individuals who are socially isolated and/or have poor coping skills. • Stress also causes a decline in the rate of formation of new neurons (neurogenesis) in the part of the brain known as the hippocampus. • Autopsy evidence suggests that depressed people who experienced chronic stress and then went on to commit suicide showed reduced neurogenesis in the hippocampus
  • 67. CAM in Neuromodulation • St. John's Wort has been used for thousands of years, and is currently one of the top selling herbs for depression. • There are many active chemical constituents in St. John's Wort. • These chemicals, called hypericin, pseudohypericin, and hyperforin, have all been investigated for their anti- depressant properties.
  • 68. • Exercising as little as three hours a week can have a profound effect on the symptoms of depression. • Researchers are puzzled about the exact reason for the benefits, but studies conducted with animals suggest that exercise increases serotonin, dopamine and norepinephrine levels. • Exercise also releases endorphins, chemicals naturally produced in the body, which reduce the experience of pain and enhance neuroplasticity, thus improving mood, learning capacity and memory.
  • 69. • Omega-3 Fatty Acids (oils), which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found primarily in fish (such as mackerel, lake trout, herring, sardines, albacore tuna, and salmon) and some plants. • There is strong evidence from epidemiological (population) studies that cultures which eat large amounts of fish containing these oils have a low incidence of depression, Alzheimer’s and stress disorders.
  • 70. • SAMe (pronounced "Sammy") stands for S- adenosyl-L-methionine. SAMe is a compound produced by the liver and used throughout the body in a chemical process called methylation. • Because there are no foods that have high SAMe levels, our bodies must make this substance. • Our liver usually creates SAMe from the amino acid methionine, which is found in many foods, with the help of vitamin B12 and folate. • The brain use of SAMe is in the creation of the neurotransmitters dopamine, serotonin and norepinephrine.
  • 71. • 5-hydoxytryptophan (5-HTP) is a compound made from the amino acid (protein) tryptophan and is primarily found in the brain. • 5-HTP is one of the basic building blocks for serotonin. • Serotonin itself can be manufactured in the laboratory, but when taken as a supplement, it cannot reach the brain . • Multiple research studies support the use of 5- HTP as a natural way to increase brain serotonin levels. • Tryptophan rich foods are milk, bananas, spinach and turkey.
  • 72. • B-vitamins, especially B1 (thiamin), B6 (pyridoxine), B9 (folic acid), and B12 (cobalamin) have all been examined for their contribution to neural plasticity. • These B-vitamins play many important roles in the body and are necessary for the manufacture of GABA, serotonin, dopamine, and other neurotransmitters responsible for regulating mood.
  • 73. • Acupuncture balances yin and yang, keeps the normal flow of energy unblocked, and restores health to the body and mind. • A Western interpretation of acupuncture is that the treatment stimulates the central nervous system, releasing chemicals into the muscles, spinal cord, and brain, promoting the body's natural healing abilities. • Acupuncture may also alter brain chemistry by changing the release of neurotransmitters and hormones that positively impact mood.
  • 74. Meditation • Meditation was conceptualized as a family of complex emotional and attentional regulatory strategies developed for various ends, including the cultivation of well-being and emotional balance. • There are two common styles of meditation, i.e., 1. Focused attention (FA) meditation and 2. Open monitoring (OM) meditation.
  • 75. • FA meditation entails voluntarily focusing attention on a chosen object in a sustained fashion. • OM meditation involves non-reactively monitoring the content of experience from moment to moment, primarily as a means to recognize the nature of emotional and cognitive patterns.
  • 76. • OM meditation initially involves the use of FA training to calm the mind and reduce distractions, but as FA advances, the cultivation of the monitoring skill per se becomes the main focus of practice. • The aim is to reach a state in which no explicit focus on a specific object is retained; instead, one remains only in the monitoring state, attentive moment by moment to anything that occurs in experience.
  • 77. The Take-away • Our brains have the lifelong ability to adapt and build. • It's true! No matter how old we get, our brains are always finding new and better ways to reorganize neural pathways (information highways, if you will) and even build brand new ones.
  • 78. • These neural "information highways" form the basis of our cognitive skills. • Cognitive skills not only make up IQ, they also determine how efficiently we're able to process information in every area of our lives. • No matter how old we get, our mental abilities (and even IQ!) are never "set in stone." • Because the brain is always adapting and building, our ability to think, remember and learn is never static— it can always be upgraded and improved!