1. Sodium hypochlorite is a commonly used disinfectant with antiviral properties. 2. The document proposes using diluted sodium hypochlorite administered intravenously or endolymphatically to treat severe viral infections like MERS. 3. Sodium hypochlorite has been approved for medical use in Russia and research shows it may be effective against various severe viral diseases.

1. Middle East Respiratory
Syndrome (MERS) : Treatment
and prophylaxis with Oxidizers.
Dmitri Popov. PhD, Radiobiology.
MD (Russia)
Advanced Medical Technology and
Systems Inc. Canada.

2. Middle East Respiratory Syndrome
• Middle East Respiratory Syndrome (MERS) is viral
respiratory illness first reported in Saudi Arabia in
2012. It is caused by a coronavirus called MERS-
CoV. Most people who have been confirmed to
have MERS-CoV infection developed severe acute
respiratory illness. They had fever, cough, and
shortness of breath. About 30% of people
confirmed to have MERS-CoV infection have died.
• http://www.cdc.gov/coronavirus/mers/

3. Middle East Respiratory Syndrome
• Countries in or near the Arabian Peninsula with MERS
Cases
• Saudi Arabia
• United Arab Emirates (UAE)
• Qatar
• Oman
• Jordan
• Kuwait
• Yemen
• Lebanon
• Iran

4. Middle East Respiratory Syndrome
• Countries with Travel-associated MERS Cases
• United Kingdom (UK)
• France
• Tunisia
• Italy
• Malaysia
• Philippines
• Greece
• Egypt
• United States of America (USA)
• Netherlands
• Algeria
• Austria
• Turkey

5. Middle East Respiratory Syndrome
• Middle East respiratory syndrome (MERS) is a
viral respiratory infection caused by the newly
identified MERS-coronavirus (MERS-CoV). MERS-
CoV is a betacoronavirus derived from bats.
Camels have been shown to have antibodies to
MERS-CoV, but the exact source of infection in
camels has not been identified. A strain of MERS-
CoV known as HCoV-EMC/2012 found in the first
patient in London in 2012 was found to have a
100% match to Egyptian tomb bats.

6. Middle East Respiratory Syndrome
• Early reports compared the virus to severe acute
respiratory syndrome (SARS), and it has been referred
to as Saudi Arabia's SARS-like virus. The first patient, in
June 2012, had a "seven-day history
of fever, cough, expectoration, and shortness of
breath. One review of 47 laboratory confirmed cases in
Saudi Arabia gave the most common presenting
symptoms as fever in 98%, cough in 83%, shortness of
breath in 72% and myalgia in 32% of patients.
• http://en.wikipedia.org/wiki/Middle_East_respiratory_
syndrome#Signs_and_symptoms

7. Middle East Respiratory Syndrome
• There were also frequent gastrointestinal symptoms with
diarrhea in 26%, vomiting in 21%, abdominal pain in 17% of
patients. 72% of patients required mechanical ventilation.
There were also 3.3 males for every female.[3] One study of
a hospital based outbreak of MERS had an
estimated incubation period of 5.5 days (95% confidence
interval 1.9 to 14.7 days).[4] MERS can range from
asymptomatic disease to severe pneumonia leading to
the acute respiratory distress syndrome.[3] Renal
failure, disseminated intravascular coagulation (DIC)
and pericarditis have also been reported.[5]
• http://en.wikipedia.org/wiki/Middle_East_respiratory_synd
rome#Signs_and_symptoms

8. Middle East Respiratory Syndrome
• Chest X-ray findings tend to show bilateral
patchy infiltrates consistent with viral
pneumonitis and ARDS. Lower lobes tend to
be more involved. CT scans show interstitial
infiltrates.
• http://en.wikipedia.org/wiki/Middle_East_res
piratory_syndrome#Signs_and_symptoms

9. Middle East Respiratory Syndrome
• Although MERS-CoV has been shown to antagonize
endogenous IFN production, treatment with exogenous types I and
IIIIFN (IFN-α and IFN-λ, respectively) have effectively reduced viral
replication in vitro.When rhesus macaques were given interferon-
α2b and ribavirin and exposed to MERS, they developed less
pneumonia than controlanimals. 5 critically ill patients with MERS
in Saudi Arabia with ARDS and on ventilators were given interferon-
α2b and ribavirin but all ended up dying of the disease. The
treatment was started late in their disease (a mean of 19 days after
hospital admission) and they had already failed trials of steroids so
it remains to be seen whether it may have benefit earlier in the
course of disease. Another proposed therapy is inhibition of viral
protease. Researchers are investigating a number of ways to
combat the outbreak of Middle East respiratory syndrome
coronavirus, including using interferon, chloroquine,
chlorpromazine, loperamide, and lopinavir.

10. Middle East Respiratory Syndrome
There has been evidence of limited, but not
sustained spread of MERS-CoV from person to
person, both in households as well as in health
care settings like hospitals. Most transmission has
occurred "in the circumstances of close contact
with severely ill patients in healthcare or
household settings" and there is no evidence of
transmission from asymptomatic cases. Cluster
sizes have ranged from 1 to 26 people, with an
average of 2.7.ferent forms of herpes.
• Can we use this method for Plague treatment?

11. Middle East Respiratory Syndrome
• Plague treatment with Na Cl O.
• Использование: медицина, для лечения острой и
хронической генерализированной вирусной инфекции,
а именно, гепатита С, герпеса, ВИЧ-инфекции.
• Method of treatment with Sodium hypochlorite currently
in use in medical practice for treatment of different forms
of Viral Infections - Viral hepatitis;
human immunodeficiency virus (HIV) is a lentivirus (a
subgroup of retrovirus) that causes the acquired
immunodeficiency syndrome (AIDS); different forms of
herpes, EBOLA, Yearsenia Pestis.
• Can we use this method for MERS treatment?

12. Middle East Respiratory Syndrome
• Plague: Treatment with Na Cl O, IV, endo-
lymphatic.
• (Разрешение Фармкомитета МЗ СССР N 418
от 13.04.91).
• Approved by National Pharmaceutical
Department. Ministry of Public Health. Russia

13. Middle East Respiratory Syndrome
Sodium hypochlorite is a chemical
compound with the formula Na Cl O - well known
disinfectant preparation and used for destruction
of viruses and bacteria on external surfaces.
• Sodium hypochlorite is a Disinfectant.
• http://en.wikipedia.org/wiki/Disinfectant
n disinfectant preparation and used for destruction
of viruses and bacteria on external surfaces.
1. Sodium hypochlorite is a Disinfectant.
2. http://en.wikipedia.org/wiki/Disinfectant

14. Middle East Respiratory Syndrome
• Sodium hypochlorite is very commonly used. Common
household bleach is a sodium hypochlorite solution and is
used in the home to disinfect different surfaces. In more
dilute form, it is used in swimming pools, and in still more
dilute form, it is used in drinking water. When pools and
drinking water are said to be chlorinated, it is actually
sodium hypochlorite or a related compound—not pure
chlorine—that is being used. Chlorine partly reacts with
proteinaceous liquids such as blood to form non-oxidizing
N-chloro compounds, and thus higher concentrations must
be used if disinfecting surfaces after blood spills.
• In more diluted and ionized form can be used for I/V
administration and treatment for deadly, severe form of
viral or bacterial infection.

15. Middle East Respiratory Syndrome
• Electrolyzed water or "Anolyte" is an oxidizing,
acidic hypochlorite solution made
by electrolysis of sodium chloride into sodium
hypochlorite and hypochlorous acid. Anolyte
has an oxidation-reduction potential of +600
to +1200 mV and a typical pH range of 3.5––
8.5, but the most potent solution is produced
at a controlled pH 5.0–6.3 where the
predominant oxychlorine species
is hypochlorous acid.

16. Middle East Respiratory Syndrome
• Sodium hypochlorite is a chemical
compound with the formula NaClO.
It is composed of a sodium cation (Na+) and a
hypochlorite anion (ClO−);
it may also be viewed as the
sodium salt of hypochlorous acid.

17. Middle East Respiratory Syndrome
• A new effective method of countermeasure
against biological weapons, antiviral
treatment of acute and chronic viral hepatitis
B and C and against other viral diseases was
used in medical practice in hospitals. Research
show this method as effective method against
severe viral infections, warfare, and outbreak
infections, Biological warfare, methicillin-
resistant staphylococcus aureus, EBOLA, SARS,
MERS.

18. Middle East Respiratory Syndrome
• Under way

19. Middle East Respiratory Syndrome
• Under way

20. Middle East Respiratory Syndrome
• Under way

21. Middle East Respiratory Syndrome
• Under way