Dignity Foundation, Dignity Lifestyle, Senior Citizen Life Enrichment Services.
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Dignity Foundation and Dignity Lifestyle provide senior citizen life enrichment services and programs in India such as recreation facilities, nursing homes, luxury homes, retirement homes, and activities through their website www.dignitylifestyle.org. They offer a guide to senior living options and retirement communities in India including seniors homes, nursing homes, luxury accommodation, and retirement townships.
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This gives us tremendous pleasure to inform you that after the completion of one year in Networking, Nestling and Nurturing the grassroot level not for profit organisations across the country we are moving to our next phase of fund raising action and attempting to indulge all the citizens of India in the great action.
The concept is Multi Level Fundraising (MLF), where you will suggest 10 new people or organisations, who have not been introduced to Lead India Foundation and give their details in the format given to you. The main aim of this program is to develop a wide network and indulge more and more people into this action.
Benefit of this program for you:
In First Month get 20,000 INR. Second Month get 45,000 INR and more. Get an opportunity to have your own business/ NGO after 6 months or 1,00,000 INR
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Ideal Indian of the Year State level: Rs 25,000 each + Certificate
Ideal India of the Year: National: 1,00,000 + Certificate
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Best networking person of the Year: 50,000 INR + Certificate
In this way as the IDEAL INDIAN, you spread the message of Lead India Foundation Concept of IDEAL INDIAN, Earn Handsome amount with very nominal fees of Rs. 300, Be your own Boss and Be Honest, Trust Worthy to your society nation and your surroundings.
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In First Month get 20,000 INR. Second Month get 45,000 INR and more. Get an opportunity to have your own business/ NGO after 6 months or 1,00,000 INR
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Agewell Foundation, established in 1999, an NGO dedicated towards the welfare of Older Persons across the country. It endeavours to bring about a change in the perception of old age and assist older persons to move surely but steadily from helplessness and self pity towards confidence, respect and mutual caring.
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Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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