Lerchl

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Lerchl

  1. 1. Actions of EMF on Development – Theoretical Targets h l Brain (e.g., Growth Hormone, LH, TSH, TRH, Melatonin) Thyroid Gland (Thyroxin) Whole Body (e.g., Temperature, Metabolism) ) Reproductive Organs (e.g, Testosterone, Estrogens)
  2. 2. Actions of EMF on Development – Theoretical Mechanisms h l h WHO Research Agenda for Radiofrequency di f Electromagnetic Fields, 2010
  3. 3. Search Results (PubMed) for Studies in  Rats or Mice ((NO Cancer Studies) d )• Search Terms (Publications from 2000 – present): ( p ) „electromagnetic AND fields AND (rats OR mice) AND  xxxxx“ xxxxx Results Relevant Effect Thyroxin 5 1 Reduction Melatonin M l t i 28 1 No Effect N Eff t LH 8 1 No Effect Testosterone 24 1 Reduction Estrogens 14 1 No Effect
  4. 4. Reported Effects on Thyroxin / TSH on Thyroxin / TSH SAR = 2 W/kg f=900 MHz 30 min / day 5 days / week 4 weeks
  5. 5. Reported Effects on Thyroxin / TSH on Thyroxin / TSHSAR = 2 W/kgf=900 MHz30 min / day30 min / day5 days / week4 weeks
  6. 6. Reported Effects on Melatonin on MelatoninSAR = 2 W/kgf=900 MHz and 1800 MHz30 min / day5 days / week5 days / week4 weeks Koyu et al., Toxicol Ind Health 21 (2005) 27‐31
  7. 7. Reported Effects on Estrogens on Estrogens Yamashita et al., Bioelectromagnetics 31 (2010) 573‐575 Y hit t l Bi l t ti 31 (2010) 573 575
  8. 8. Studies in AKR/J Mice (900 MHz) in AKR/J Mice (900 MHz)N=160 / group; SAR = 0.4 W/kg (24/7)Blinded design Sommer et al., BMC Cancer 4 (2005): 77
  9. 9. Studies in AKR/J Mice (900 MHz) in AKR/J Mice (900 MHz)N=160 / group; SAR = 0.4 W/kg (24/7)Blinded design Sommer et al., BMC Cancer 4 (2005): 77
  10. 10. Studies in AKR/J Mice (900 MHz) in AKR/J Mice (900 MHz) P<0.01 P<0 01N=160 / group; SAR = 0.4 W/kg (24/7)Blinded design Sommer et al., BMC Cancer 4 (2005): 77
  11. 11. Effects of EMF (900 MHz) on Metabolism in Hamsters (Pilot Study)M t b li i H t (Pil t St d ) Lerchl et al, BEMS 2008
  12. 12. Studies in AKR/J Mice (1966 MHz; UMTS) N=160 / group; SAR = 0.4 W/kg (24/7) Blinded design Sommer et al., Radiat Res 168 (2007): 72 ‐ 80
  13. 13. Studies in AKR/J Mice (1966 MHz; UMTS) n.s.N=160 / group; SAR = 0.4 W/kg (24/7)Blinded design Sommer et al., Radiat Res 168 (2007): 72 ‐ 80
  14. 14. Mice Multigeneration Study (1966 MHz; UMTS) (1966 MH UMTS)N=32 pairs (2 females, 1 male) per group; 4 exposure groups (0, 0.08, 0.4, 1.3 W/kg); 4 generations; exposure 24/7; blinded design
  15. 15. Mice Multigeneration Study (1966 MHz; UMTS) ( ) Sommer et al., Radiat Res 171 (2009) 89‐95
  16. 16. Mice Multigeneration Study (1966 MHz; UMTS) ( ) Sommer et al., Radiat Res 171 (2009) 89‐95
  17. 17. Mice Multigeneration Study (1966 MHz; UMTS) ( ) Sommer et al., Radiat Res 171 (2009) 89‐95
  18. 18. Effects of Head‐Only Exposure (900 MHz) on Development, Learning and Memory i l i d in Rats
  19. 19. Effects of Head‐Only Exposure (900 MHz) on Development, Learning and Memory i l i d in Rats
  20. 20. Effects of Head‐Only Exposure (900 MHz) on Development, Learning and Memory i l i d in Rats• N = 24 rats per group N = 24 rats per group• SAR (brain) = 0, 0.4, 2 and 10 W/kg (blinded)• Exposure 2 h / d 2 h / day, 5 days / d / week k• Exposure started at an age of 14 days (!)• Battery of behavioral tests: – 8‐arm maze 8a ae – Rotarod wheel 3 times during experiment: ‐ juvenile (completed) – Open field Open field ‐ adult d l – Water maze ‐ pre‐senile
  21. 21. Conclusions• Relatively little is known about direct effects of RF‐ EMF exposure on hormones EMF exposure on hormones involved in develop in develop‐ ment in untreated animals (mice or rats).• Chronic exposure of AKR/J or normal mice (in a of AKR/J or normal mice (in a  multigeneration study) revealed no adverse effects on health or development at rather high SAR values.• „Sub“‐thermal metabolic effects should be further investigated. Relation to EEG effects in humans???• The ongoing study on rats (head‐only exposure) will  help to clarify effects of exposure in juvenile animals.
  22. 22. Acknowledgements• Projects funded by the Bundesamt für Projects funded by the Bundesamt für  Strahlenschutz (BfS), Germany• Dr. Melanie Klose, Dr. Angela Sommer, Dr. Dr. Melanie Klose, Dr. Angela Sommer, Dr.  Kirsten Schwarzpaul, Karen Grote, Thomas  Ströhlein (Jacobs University)• Nina Kloss (Jacobs University, 2nd year undergraduate, project on temperatures)• Volkert Hansen, Joachim Streckert, Andreas  Bitz (Universities Wuppertal and Essen)
  23. 23. Thank you for your attention!

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