Anti viral 1

Antiviral Agents ,[object Object],[object Object],[object Object],[object Object]

Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nucleoside Analogues General Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acyclovir and Valacyclovir (prodrug, better availability) ,[object Object],Acyclovir AcycloGMP AcycloGTP Thymidine kinase Cellular kinases Viral 200x affinity of mammalian ,[object Object],[object Object],Resistance: 1. ↓ activity of thymidine kinase 2. altered DNA polymerase Toxicity: 1. Encephalopathy 2. Renal Insuficiency Use: 1. H. simplez I and II 2. H. zoster and Varicella, not good for CMV

Ganciclovir ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other Nucleoside Analogues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Foscarnet ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anti-retroviral Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other Retroviral RT Inhibitors ,[object Object],[object Object]

Protease Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object]

Panel C shows the translational products of the HIV gag–pol gene and the sites at which the gene product is cleaved by the virus-encoded protease. p17 denotes capsid protein, p24 matrix protein, and p7 nucleocapsid; p2, p1, and p6 are small proteins with unknown functions. The arrows denote cleavage events catalyzed by the HIV-specific protease. Protease Inhibitors Protease action

Fig. 3. HIV-1 virion forms. (a) Particles assembling and budding at the cell membrane. (b) An immature virus particle. (c) Mature forms of HIV-1.

Other Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anti viral 1

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Anti viral 1