Relation of ig e , eosinophil & asthma

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Ma Wady

PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB BACHELOR MEDICINE AND SURGERY (MBBS) UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

Health & Medicine

1
Relation of Ig E , eosinophil & asthma
PROBLEM BASED LEARNING (PBL)
PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB
BACHELOR MEDICINE AND SURGERY (MBBS)
UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

Mechanism of action
Antigen were inhaled by Amna
(cat dander and housemite dust)
Human airway smooth muscle
cells will release
Eotaxin (chemokine)
Eosinophil recruitment to the site

Mechanism of action
Eosinophil processed the antigen
& presenting the MHC class II
T-helper cell recognize the MHC class II
Naïve T helper cell (Th0)
will release IL-4 and IL-5

Mechanism of action
Become (Th2)
- humoural immunity response –
B cell proliferates & differentiate
Will produced
immunoglobulin E-producing plasma cell

Mechanism of action
Subsequent exposure of the same Ag
will aggregate the release of histamine
Will result the symptoms of Asthma
(airway constriction)

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