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Genetic Insights Into Multiple Sclerosis Pathogenesis
 

Genetic Insights Into Multiple Sclerosis Pathogenesis

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A segment of a group presentation reflecting upon some of the genetic components that may contribute to Multiple Sclerosis pathogenesis. ...

A segment of a group presentation reflecting upon some of the genetic components that may contribute to Multiple Sclerosis pathogenesis.

IL2Rα and IL7Rα were the two genes of focus.

(This presentation was originally done for Semester 2 , 2008)

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    Genetic Insights Into Multiple Sclerosis Pathogenesis Genetic Insights Into Multiple Sclerosis Pathogenesis Presentation Transcript

    • Investigating Multiple Sclerosis
    • An Introduction
      Multiple Sclerosis (MS) is the most prevalent autoimmune disease among young people, affecting between 2 and 150 people per 100,000.
      It is a condition that attacks and destroys myelin, an insulating substance that aids neural transmission in the Central Nervous System (CNS).
    • Aetiology of MS
      • The aetiology of Multiple Sclerosis (MS) is largely unknown; however, the predominant theory today is that the disease is autoimmune in nature.
      • Both environmental and genetic factors contribute to the vulnerability and pathogenesis of the disease and its suggested triggers of exacerbation include physical injury, bacterial or viral infections, stressful life events, and genetic susceptibility.
      • Considerable research suggests an inflammatory cycle
      Winquist, R.J, Kwong, A, Ramachandran, R, Jain, J (2007). The Complex Etiology of Multiple Sclerosis. Biochemical Pharmacology74:1321-1329.
    • Genetic insights into Multiple Sclerosis Pathogenesis
      Aaron Sparshott
    • An Introduction
      The pathogenesis of MS is the result of complex interactions between genes and the environment.
      ~50% of MS cases can be explained by the heritable component.
      Certain human leukocyte antigen (HLA) factors belonging to the major histocompatibility complex (MHC) on chromosome 6 were shown in the 1970s to have strong associations with MS and other autoimmune diseases (e.g. diabetes).
      To date HLA Factors have shown the strongest correlations to MS pathogenesis
      Genetic MS susceptibility however is not limited to one gene, but is rather the sum of a number of variant genes exerting small contributory effects.
    • MS associated genes
      A list of 17 single nucleotide polymorphisms (SNPs) in 13 different gene loci was established by the IMSGC* in 2007, with an association (P<6x10-3) with MS susceptibility.
      Two significant non-HLA MS linked gene loci based on statistical evidence and function where; IL2Rα and IL7Rα
      • HLA-DRα
      • IL2Rα (2)
      • IL7Rα
      • CBLB
      • DBC1
      • CD58
      • KLRB1
      • PDE4B
      • ALK
      • FAM69α (2)
      • KIAA0350
      • RPL5
      • ANKRD15
      • EV15 (2)
      Level of significance of genetic region with MS susceptibility
      HAFLER ET AL. (2007) Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. N Engl J Med. 357(9):851-62.
      * International Multiple Sclerosis Genetics Consortium
    • Non-HLA Genes
      A number of other gene loci on chromosome1p22 have also shown links to MS pathogenesis.
      The discovery of new linked genes opens new avenues for pharmacological targets and therapeutic strategies.
      Both cytokines are of central importance in promoting the growth and differentiation of T and B cells.
    • IL2Rα’s Role in pathogenesis
      Proposed Mechanism
      Regulatory T cells are crucial for the maintenance of immunological tolerance.
      SNPs in IL2Rα cause a loss in regulatory T cell function, thus limiting the body’s ability to control auto-reactive T cells that have escaped the process of negative selection in the thymus.
      T cells which subsequently assist in the autoimmune reaction.
      Pharmacological Targets & Therapeutic Strategies
      In support of this association stage 2 trials of Daclizumab (Zenapax®) a monoclonal antibody targeting the IL2Rα chain have shown clinical efficacy.
    • Importance of Genetic Research
      Current Research
      Refined the knowledge of MS pathogenesis
      Provided supporting evidence for the scientific community’s consensus that MS is an autoimmune inflammatory disorder
      Led to the development of new pharmacological targets and therapeutic strategies for MS.
      Future Research
      Biomarkers for early diagnosis
      Preventative strategies
      Treatments and therapies designed specifically for the individual