Coating of Pharmaceutical Products

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CoatingofCoatingof
PharmaceuticalPharmaceutical
ProductsProducts

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3. Convertible Coating
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 Non-Convertible Coating.
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4. Purpose of CoatingPurpose of Coating::
1. Protection against light, air and moisture.
2. Protecting API against digestive fluids.
3. Ensure Controlled Release
4. Avoiding Side effects, masking taste.
5. Ensure eligible appearance.
6. Increase drug safety by better identification.
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9. Core types
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11. Core Related Factors affecting Coating
process:
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Coating EquipmentCoating Equipment

13. Coating Liquid
 Polymer (Film former).
 Solvent ( Vehicle ).
 Plasticizer.
 Opacifier.
 Colorant.
 Flavoring agents and Sweeteners.
 Wetting agent.
 Anti-adherent.
 Others.
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14. Polymer.
Function: film former.
A.Immediate Release coating polymers:
Readily soluble in aqueous media.
a. Cellulose Derivatives: HPMC, HPC,MC.
(Have good mechanical properties).
b. Vinyl Derivatives: PVP, PVA.
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15. B. Modified Release Coating Polymers
a. Extended Release Coating polymers:
- They are dissolved in organic solvent or dispersed
in aqueous medium, such as (EC).
b. Enteric Coating polymers
- Methacrylic acid and polyacrylate derivatives such
as Eudragit.
- Phthalate esters like cellulose acetate phthalate
(CAP).
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16. Plasticizers
- Increasing elasticity of the coat.
- They have low molecular weight.
- Alter the physical properties of the
polymer.
- Examples:
PEG, Phthalate esters, Castor oil,
monoglycerides and coconut oil. 16

17. Coating PansCoating Pans
Conventional Coating Pans.
Perforated Coating Pans.
Air suspension Coating systems.
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39. CoatingCoating ProblemsProblems
Logo Bridging
Twinning
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40. CoatingCoating ProblemsProblems
Logo Infilling
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41. Coating problemsCoating problems
Core Erosion
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42. CoatingCoating ProblemsProblems
Picking and Sticking
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43. Tablet to tablet color
variation
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CoatingCoating problemsproblems

44. CoatingCoating problemsproblems
Orange peel
roughness
Cracking
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45. CoatingCoating ProblemsProblems
Peeling
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46. CoatingCoating ProblemsProblems
Edge Chipping & Erosion
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47. Thank You
for
Your Attention …
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