3. E. Histolytica infections
90% by non-pathogenic 10% only by
strains pathogenic ones
10%
90% subclinical symptomatic
infection
4. Route of infection
“ORAL”
Mode of infection
ingestion of contaminated food or
water with CYSTS
5. Clinical Features of Amebiasis
Amebic Colitis
Fulminating Enterocolitis
Ameboma
Amebic Liver Abscess
6. Amebic Colitis
Weight loss
( failure to thrive)
Diarrhea with:
“blood” or
“mucous” or both
Diarrhea in Amebic colitis can be:
Mild, frequent, severe
7. Cysts colonize the epithelial surface of the colon
(most frequently in the cecum & ascending colon)
What is dysentery?
inflammatory disorder of the colon, that results in severe
diarrhea containing mucus and/or blood in the feces with
abdominal pain.
When it develops?
Once amebae attach to the colonic epithelium
8. “intestinal amoebiasis”
Incubation period: 2 weeks to many years!
Most cases are asymptomatic.
Course of the disease:
Chronic course with abdominal pains (right lower
quadrant), two or more unformed
stools / day.
*Simulate acute appendicitis* WHY?
9. Cont’d
Systemic manifestation of fever or lethargy?
Flask shaped ulcers!
Examination of ulcer edge >>> no inflammatory
cells! WHY?
>>> hematogenous trophozoites
10. Complications of amebic colitis
Anemias
(iron deficiency, or Megaloblastic)
Megacolon
Mortality
