Entamoeba histolytica

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Entamoeba histolytica

  1. 1. Entamoeba histolytica
  2. 2. E.Histolytica fits in the category of . . . . ?Nomenclature?What is amebiasis?
  3. 3. E. Histolytica infections90% by non-pathogenic 10% only by strains pathogenic ones 10% 90% subclinical symptomatic infection
  4. 4. Route of infection “ORAL” Mode of infectioningestion of contaminated food or water with CYSTS
  5. 5. Clinical Features of AmebiasisAmebic Colitis Fulminating Enterocolitis Ameboma Amebic Liver Abscess 
  6. 6. Amebic ColitisWeight loss( failure to thrive)Diarrhea with:“blood” or“mucous” or bothDiarrhea in Amebic colitis can be:Mild, frequent, severe
  7. 7. Cysts colonize the epithelial surface of the colon(most frequently in the cecum & ascending colon)What is dysentery?inflammatory disorder of the colon, that results in severediarrhea containing mucus and/or blood in the feces withabdominal pain.When it develops?Once amebae attach to the colonic epithelium
  8. 8. “intestinal amoebiasis”Incubation period: 2 weeks to many years!Most cases are asymptomatic.Course of the disease:Chronic course with abdominal pains (right lowerquadrant), two or more unformedstools / day.*Simulate acute appendicitis* WHY?
  9. 9. Cont’dSystemic manifestation of fever or lethargy?Flask shaped ulcers!Examination of ulcer edge >>> no inflammatorycells! WHY? >>> hematogenous trophozoites
  10. 10. Complications of amebic colitisAnemias(iron deficiency, or Megaloblastic)MegacolonMortality

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