E.Histolytica fits in the category of . . . . ?Nomenclature?What is amebiasis?
E. Histolytica infections90% by non-pathogenic 10% only by strains pathogenic ones 10% 90% subclinical symptomatic infection
Route of infection “ORAL” Mode of infectioningestion of contaminated food or water with CYSTS
Clinical Features of AmebiasisAmebic Colitis Fulminating Enterocolitis Ameboma Amebic Liver Abscess
Amebic ColitisWeight loss( failure to thrive)Diarrhea with:“blood” or“mucous” or bothDiarrhea in Amebic colitis can be:Mild, frequent, severe
Cysts colonize the epithelial surface of the colon(most frequently in the cecum & ascending colon)What is dysentery?inflammatory disorder of the colon, that results in severediarrhea containing mucus and/or blood in the feces withabdominal pain.When it develops?Once amebae attach to the colonic epithelium
“intestinal amoebiasis”Incubation period: 2 weeks to many years!Most cases are asymptomatic.Course of the disease:Chronic course with abdominal pains (right lowerquadrant), two or more unformedstools / day.*Simulate acute appendicitis* WHY?
Cont’dSystemic manifestation of fever or lethargy?Flask shaped ulcers!Examination of ulcer edge >>> no inflammatorycells! WHY? >>> hematogenous trophozoites
Complications of amebic colitisAnemias(iron deficiency, or Megaloblastic)MegacolonMortality