7. Lower vs. Upper Motor Neuron Weakness *Disuse atrophy can develop after initial presentation Down-going Up-going (Babinski’s sign) Toes Decreased or absent Increased (spasticity) Tone Present Absent Fasciculations Present Absent* Atrophy Diminished or absent Hyperactive +/- clonus Reflexes Lower Motor Neuron (Anterior horn cells to peripheral nerves) Upper Motor Neuron (Brain to corticospinal tract)
34. Myositis-Specific Autoantibodies (MSA) Source: Dr. R. Shupak, St. Michael ‘s Hospital Pathogenesis of Idiopathic Inflammatory Myopathy Rheumatology Rounds: April 5, 2005
35. Myositis-Specific Autoantibodies Source: Dr. R. Shupak, St. Michael ‘s Hospital Pathogenesis of Idiopathic Inflammatory Myopathy Rheumatology Rounds: April 5, 2005