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A.R. Life Sciences
Group
CORPORATE PROFILE
Index
Brief Profile
Operating Verticals
Infrastructure
Products – API’s
Research & Development
Quality Systems/ GMP Certifications
Regulatory Affairs
Pollution Control Health and Safety Standards
A.R. Life Group
A.R. LIFE SCIENCES (ARLS) – Brief Profile
Evolution of A R Life - 1996.
Leadership
Mr. Kallam Subba Reddy, Managing Director ,
Strong legacy working with Dr. Reddy’s for over
20 years
Mr. Krishna Chaitanya, Executive Director
Marketing & Operations. From India's premier
institute - IIT Roorkee
Product Verticals - Intermediates & APIs
Acquired Dymes Pharmachem Ltd (Dymes) in 2014
Global Network
Total employees: 100 to 120
Aim – GLOBAL LEADER IN Intermediates and APIs
A.R. Life Group
PRODUCT VERTICALS
APIs:
Current Portfolio : 2
Under Development: 3
INTERMEDIATES:
Current Portfolio : 27 Intermediates
Under Development : 12 Intermediates
COSMETICS & PRESERVATIVES
Cosmetics Ingredients : 10
Preservative under development: 1
Pharmaceutical IntermediatesActive Pharmaceutical Ingredients
Key Business Segments
A.R. Life Group
ARLS - Infrastructure
Intermediates Manufacturing Facility with Multi product
manufacturing capabilities.
Operations
Total Plant Area : 4047 Sq Mts
Total No of Reactors : 20 (15 SSR & 5 GLR)
Reaction Volume with Concurrent scaling-up and Piloting: Over 35
KL
Complete Onsite QA/QC/RA/R&D Support
No of Employees : 60
Dedicated block to carry out high pressure reactions
Quality Control:
Dedicated Analytical and Wet Lab with the following Major Analytical
Equipment
HPLC – 3 Nos
GC – 2 Nos
Potentiometer – 1 Nos
Others – KF Titrator, Melting range
apparatus, UV chamber, pH meter, Ovens, muffle
furnace, etc.,
A.R. Life Group
Dymes - Infrastructure
Operations
Total Plant Area : 5466 Sq Mts
Total No of Reactors : 25
Reaction Volume with Concurrent scaling-up and Piloting
:50KL
No of production blocks : 2
Pharma area : 2 clean room
Complete Onsite QA/QC/RA/R&D Support
No of Employees : 65
One dedicated block to carry out high pressure reactions (upto
40 kg), cryogenic reactions (upto -80 Deg C) available
Quality Control:
Dedicated Analytical and Wet Lab with the following Major
Analytical Equipment
HPLC – 3 Nos (Including one with RI
detector)
GC – 2 Nos
IR – 1 Nos
Others – KF Titrator, Melting range
apparatus, UV chamber, pH meter, Ovens, muffle furnace,
weighing balances, etc A.R. Life Group
Intermediates Product List
High Quality intermediates for following APIs
Commercialised :
Ondansetron
Racecadotril
Dabigatran
Ibandronate Sodium
Zoledronic acid
Mirabegron
Clopidogrel bi sulphate
Sitagliptin
Dabigatran
Developed in lab to be commercialized:
Quetiapine Fumarate
Tenofovir
Bendamustine
Dasatinib
A.R. Life Group
API Product List*
GENERIC NAME CAS NO SPECIFICATION THERAPEUTIC USAGE STATUS
Clopidogrel bi sulphate 120202-66-6 USP Cardiovascular Commercial
Sitagliptin phosphate 654671-77-9 In-house Anti-Diabetic Lab Scale
Dabigatran Etexilate
Mesylate
872728-81-9 In-house Anti-Coagulant
Under
Development
Quetiapine fumarate 111974-72-2 IP / USP Anti-psychotic
Under
Development
Rosuvastatin Calcium 147098-20-2 IP Anti-lip emic
Under
Development
A.R. Life Group
Research & Development
Fully Integrated & Qualified R&D Team of 12 Scientists
Key Functions
Identification and Development
Characterization and Synthesizing of Impurities
Analytical methods developments
Key Initiatives of On site R&D team
Cost Reduction & Quality Improvement
Technology Transfer from R&D to Plant (Scale up &
Validations)
Troubleshooting
Customer support
A.R. Life Group
DYMES - PHOTOS
A.R. Life Group
DYMES -PHOTOS
A.R. Life Group
CLEAN ROOM -PHOTOS
A.R. Life Group
ARLS -PHOTOS
A.R. Life Group
Reaction Capabilities
Grignard reactions
Hydrogenation
Alkylation reactions
Halogenations reactions.
Oxidation reactions
Reduction reactions
Esterification reactions
Hydrolysis reactions
Condensation reactions
De-hydrogination reactions.
Allylic bromination reactions
Cyclization reactions
A.R. Life Group
Regulatory Affairs
Regulatory system in place for preparation and
filing of DMF, CEP, CTD, etc
Open part DMF level documentation support for
intermediates also
A.R. Life Group
Quality Systems
Both Plants meet International Standards
World Class Quality Assurance team Complying to GMP
guidelines
ISO Certification for both units and GMP &WHO GMP
certification for Dymes plant
Quality control department equipped with instruments like
HPLC, and GC
Extensive SOPs including
Change control
Equipment qualification and calibration
Process validation
Deviation handling
Customer complaint handling
GMP trainings conducted from time to time
A.R. Life Group
GMP Certifications / Compliance
ISO 9001 -2008 Certified
WHO GMP certificate (India)
Approved Vendor for Various Major Pharmaceutical
companies World Wide including Dr Reddy’s
Laboratories Ltd, Teva API, Moehs, Cipla, Torrent,
Cadila,etc.,
A.R. Life Group
Pollution Control, Health and safety
Standards
Pollution Control
Fully Integrated ETF plant ensures zero discharge
Solid waste sent to State approved disposal facility
Scrubbing systems in place to ensure acidic vapours do not
go into atmosphere
Health
Nose Masks, hand gloves and goggles worn
Regular health check-up
Regular Trainings session on care to be taken in chemical
plant
Safety
PPE for all employees including casual labour
Earthing wherever there is a possibility of static electricity
Safety trainings (Education on static electricity and its
avoidance, use of fire extinguishers, Mock drills, etc.,)
conducted from time to time
A.R. Life Group
THANK YOU
Registered Office:
H.No. 8-3-222/1/5, Behind Allahabad Bank, Madhuranagar, Yousufguda Road,
Hyderabad - 500 038.
(Email: info@arlifesciences.com)
Sites Address 1: Sites Address 2:
A R Life Sciences Pvt Ltd: Dymes Pharmachem Ltd:
Plot No. 338, Plot No. 33,
S.V. Co-operative Industrial Estate, S.V. Co-operative Jeedimetla,
Hyderabad - 500 055. Jeedimetla, Hyderabad - 500 055.
Telangana. India Telangana, India.
A.R. Life Group

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Pharmaceutical Products by A.R. Life Sciences Private Limited Hyderabad

  • 2. Index Brief Profile Operating Verticals Infrastructure Products – API’s Research & Development Quality Systems/ GMP Certifications Regulatory Affairs Pollution Control Health and Safety Standards A.R. Life Group
  • 3. A.R. LIFE SCIENCES (ARLS) – Brief Profile Evolution of A R Life - 1996. Leadership Mr. Kallam Subba Reddy, Managing Director , Strong legacy working with Dr. Reddy’s for over 20 years Mr. Krishna Chaitanya, Executive Director Marketing & Operations. From India's premier institute - IIT Roorkee Product Verticals - Intermediates & APIs Acquired Dymes Pharmachem Ltd (Dymes) in 2014 Global Network Total employees: 100 to 120 Aim – GLOBAL LEADER IN Intermediates and APIs A.R. Life Group
  • 4. PRODUCT VERTICALS APIs: Current Portfolio : 2 Under Development: 3 INTERMEDIATES: Current Portfolio : 27 Intermediates Under Development : 12 Intermediates COSMETICS & PRESERVATIVES Cosmetics Ingredients : 10 Preservative under development: 1 Pharmaceutical IntermediatesActive Pharmaceutical Ingredients Key Business Segments A.R. Life Group
  • 5. ARLS - Infrastructure Intermediates Manufacturing Facility with Multi product manufacturing capabilities. Operations Total Plant Area : 4047 Sq Mts Total No of Reactors : 20 (15 SSR & 5 GLR) Reaction Volume with Concurrent scaling-up and Piloting: Over 35 KL Complete Onsite QA/QC/RA/R&D Support No of Employees : 60 Dedicated block to carry out high pressure reactions Quality Control: Dedicated Analytical and Wet Lab with the following Major Analytical Equipment HPLC – 3 Nos GC – 2 Nos Potentiometer – 1 Nos Others – KF Titrator, Melting range apparatus, UV chamber, pH meter, Ovens, muffle furnace, etc., A.R. Life Group
  • 6. Dymes - Infrastructure Operations Total Plant Area : 5466 Sq Mts Total No of Reactors : 25 Reaction Volume with Concurrent scaling-up and Piloting :50KL No of production blocks : 2 Pharma area : 2 clean room Complete Onsite QA/QC/RA/R&D Support No of Employees : 65 One dedicated block to carry out high pressure reactions (upto 40 kg), cryogenic reactions (upto -80 Deg C) available Quality Control: Dedicated Analytical and Wet Lab with the following Major Analytical Equipment HPLC – 3 Nos (Including one with RI detector) GC – 2 Nos IR – 1 Nos Others – KF Titrator, Melting range apparatus, UV chamber, pH meter, Ovens, muffle furnace, weighing balances, etc A.R. Life Group
  • 7. Intermediates Product List High Quality intermediates for following APIs Commercialised : Ondansetron Racecadotril Dabigatran Ibandronate Sodium Zoledronic acid Mirabegron Clopidogrel bi sulphate Sitagliptin Dabigatran Developed in lab to be commercialized: Quetiapine Fumarate Tenofovir Bendamustine Dasatinib A.R. Life Group
  • 8. API Product List* GENERIC NAME CAS NO SPECIFICATION THERAPEUTIC USAGE STATUS Clopidogrel bi sulphate 120202-66-6 USP Cardiovascular Commercial Sitagliptin phosphate 654671-77-9 In-house Anti-Diabetic Lab Scale Dabigatran Etexilate Mesylate 872728-81-9 In-house Anti-Coagulant Under Development Quetiapine fumarate 111974-72-2 IP / USP Anti-psychotic Under Development Rosuvastatin Calcium 147098-20-2 IP Anti-lip emic Under Development A.R. Life Group
  • 9. Research & Development Fully Integrated & Qualified R&D Team of 12 Scientists Key Functions Identification and Development Characterization and Synthesizing of Impurities Analytical methods developments Key Initiatives of On site R&D team Cost Reduction & Quality Improvement Technology Transfer from R&D to Plant (Scale up & Validations) Troubleshooting Customer support A.R. Life Group
  • 10. DYMES - PHOTOS A.R. Life Group
  • 14. Reaction Capabilities Grignard reactions Hydrogenation Alkylation reactions Halogenations reactions. Oxidation reactions Reduction reactions Esterification reactions Hydrolysis reactions Condensation reactions De-hydrogination reactions. Allylic bromination reactions Cyclization reactions A.R. Life Group
  • 15. Regulatory Affairs Regulatory system in place for preparation and filing of DMF, CEP, CTD, etc Open part DMF level documentation support for intermediates also A.R. Life Group
  • 16. Quality Systems Both Plants meet International Standards World Class Quality Assurance team Complying to GMP guidelines ISO Certification for both units and GMP &WHO GMP certification for Dymes plant Quality control department equipped with instruments like HPLC, and GC Extensive SOPs including Change control Equipment qualification and calibration Process validation Deviation handling Customer complaint handling GMP trainings conducted from time to time A.R. Life Group
  • 17. GMP Certifications / Compliance ISO 9001 -2008 Certified WHO GMP certificate (India) Approved Vendor for Various Major Pharmaceutical companies World Wide including Dr Reddy’s Laboratories Ltd, Teva API, Moehs, Cipla, Torrent, Cadila,etc., A.R. Life Group
  • 18. Pollution Control, Health and safety Standards Pollution Control Fully Integrated ETF plant ensures zero discharge Solid waste sent to State approved disposal facility Scrubbing systems in place to ensure acidic vapours do not go into atmosphere Health Nose Masks, hand gloves and goggles worn Regular health check-up Regular Trainings session on care to be taken in chemical plant Safety PPE for all employees including casual labour Earthing wherever there is a possibility of static electricity Safety trainings (Education on static electricity and its avoidance, use of fire extinguishers, Mock drills, etc.,) conducted from time to time A.R. Life Group
  • 19. THANK YOU Registered Office: H.No. 8-3-222/1/5, Behind Allahabad Bank, Madhuranagar, Yousufguda Road, Hyderabad - 500 038. (Email: info@arlifesciences.com) Sites Address 1: Sites Address 2: A R Life Sciences Pvt Ltd: Dymes Pharmachem Ltd: Plot No. 338, Plot No. 33, S.V. Co-operative Industrial Estate, S.V. Co-operative Jeedimetla, Hyderabad - 500 055. Jeedimetla, Hyderabad - 500 055. Telangana. India Telangana, India. A.R. Life Group