some info about BBs

1. BBs
USR
Ibra Cham

2. MOA
• Cardiovascular System
 have negative inotropic and chronotropic effects on the heart
 increase PR intervals by slowing AV conduction
 prevent B2 mediated vasodilation
 prevent release of renin by SNS’s influence
• Respiratory System
 increase bronchial resistance
• Eye
 reduce intraocular pressure

3. • Metabolism
 inhibit lipolysis caused by SNS
 partially inhibit glycogenolysis caused by liver
 increase VLDL and dcrease HDL

4. Selectivity
• Covalent, electrostatic, and hydrophobic bonds 
~ less reactive more selective
• Types of B Rs

7. Examples
• Nonselective
 Propranolol, Nadolol, Timolol, and Pindolol
• Selective B1
 Acebutolol, Atenolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, and Nebivolol
• Selective B2
 Butoxamineis
• Others
 Partial Agonists
 Acebutolol and Pindolol
 Inverse Agonists
 Metoprolol
 Alpha and Beta
 Labetalol and carvedilol