2. <<Pharmaceutical fMRI, phMRI>> combining fMRI
with drug delivery, this non-invasive tool assists in
drug discovery and development making your pre-
clinical and clinical trials more effective.

3. What is functional MRI?
“fMRI is the holy grail of brain imaging…fMRI
machines use powerful magnets and complex
mathematical analysis to detect subtle changes in
blood flow to specific parts of the brain, ultimately
representing brain activity in color-coded images that
look something like Doppler weather reports. You'll
need an expert to interpret these images, unless
you're harboring a grad degree in neuroscience”.
Steven Berlin Johnson (Discover Magazine)

4. Synthesis of Drug Intervention in
CNS disorder Studies Using fMRI
Fundamental Principles:
Taking known psychological facts about syndromes, DSM IV
etc.
Using scientific facts about brain anatomy and function
Indentifying potential ROIs based on previous related research
Event related Design
Comparison group to determine what “normal” activation is
Several scan sessions, including preliminary structural MRI
Use of psychological testing outside of the scanner to compare
results of treatment on written vs. functional testing.

5. Applying fMRI
Making fMRI Work For You
STUDY PLANNING
STUDY EXECUTION
ANALYSIS AND
REPORTING
CONSULTING

6. Study Planning
Paradigm Design
Pilot Study
Working with Experts
Optimization of
Sequences
Physics
Neuropsychology
Administration
Customer Service

7. Study Execution
Subject Recruitment
CRO
Subject Management
and Training
Subject Reimbursement
IRB
fMRI Scanning at the
Applied fMRI Institute’s
Siemen 3T tim Trio

8. Analysis & Reporting
On Site Data Analysis
System
Data Analysis Specialist
Standard Reports
Customized Reports
AFNI and Brain Voyager

9. Consulting
Never done fMRI before?
That’s OK!
Team of Experts
Design Your Study
We Make fMRI Work
for You!

10. Conclusion
fMRI can aid in drug development
on many levels
The Applied fMRI Institute is
here to help