Melissa Green - Social Cognition in Schizophrenia

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Melissa Green presentation at the Schizophrenia Research Forum's live event of February 23, 2016 - www.schizophreniaforum.org.

Health & Medicine

Psychiatry
SOCIAL COGNITION IN SCHIZOPHRENIA
Associate Professor Melissa Green, PhD.
NHMRC Biomedical Career Development Fellow
School of Psychiatry, Faculty of Medicine
University of New South Wales, Australia.

Themes for discussion:
1. Gestalt processing: holistic ‘integration’ of social and emotional
information from various sources – problems with this may affect
social/emotion perception as well as emotion regulation
2. Cross-modality integration of contextual cues: involves both cognitive and
social cognitive information; implications for neural circuitry
3. Emotion regulation: aberrant physiology Vs. intact emotional experience

Integration of contextual cues in social cognition

Visual attention to context
Schizophrenia Healthy Control
 Avoidance of contextual information in Scz
Green, M.J., Waldron, J.H., Simpson, I., & Coltheart, M. (2008). Visual processing of social context during mental
state perception in schizophrenia. Journal of Psychiatry & Neuroscience, 33(1), 34-42.

SCZ are delayed in directing attention to contextual cues
p<.001
Green, M.J., Waldron, J.H., Simpson, I., & Coltheart, M. (2008). Visual processing of social context during mental
state perception in schizophrenia. Journal of Psychiatry & Neuroscience, 33(1), 34-42.

22 SCZ and 22 healthy
control participants
28 story-face pairs
discrepant in emotion content
SCZ judged expression based
on facial information or
unrelated emotions (51%)
versus controls (38%)
DISCREPANT STORY-FACE TASK
ANGER >>> FEAR
A man is returning
to his new car in
the parking lot and
sees some kids
running around
waving hubcaps in
the air. When he
gets to the car his
hubcaps are
missing…
Integration of contextual information across modalities
Green, Waldron, & Coltheart (2007), Cognitive Neuropsychiatry, 12(3), 259-280

SOURCE: Morris, Sparks, Mitchell, Shannon Weickert, Green. (2012). Cortico-limbic decoupling
during emotion regulation in bipolar disorder and schizophrenia. Translational Psychiatry. 2, e90
EMOTION REGULATION

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Image Ratings
Subjective AFFECT RATINGS
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*
* = p < .05
** = p < .01

MRI scan as stressor
SOURCE: Girshkin, L., O’Reilly, Quidé, Y., Teroganova, N., Rowland, J.E., Schofield, P.R.,
Green. M.J. (2016). Diurnal cortisol variation and cortisol response to an MRI stressor in
schizophrenia and bipolar disorder. Psychoneuroendocrinology, available online.

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In this lecture on circulatory shock, Dr. Faiza, an Assistant Professor of Physiology, delves into the profound implications of inadequate blood flow throughout the body, leading to tissue damage. The session begins by defining circulatory shock and elucidating its physiological causes, including decreased cardiac output, diminished blood volume, decreased vascular tone, obstruction to blood flow, excess metabolic rate, and abnormal perfusion patterns. Dr. Faiza categorizes shock into various types, such as cardiogenic shock, hypovolemic shock, neurogenic shock, obstructive shock, anaphylactic shock, and septic shock, and explores the pathophysiological basis of each. Furthermore, the lecture examines the stages of shock, from the non-progressive phase where compensatory mechanisms aim for full recovery to the progressive phase where shock worsens steadily without intervention, potentially leading to irreversible damage. Dr. Faiza discusses therapeutic interventions for shock, including replacement therapy, blood and plasma transfusion, sympathomimetic drugs, and other adjunctive treatments like head-down positioning, oxygen therapy, and glucocorticoids.

Circulatory Shock, types and stages, compensatory mechanisms

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