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Human Longevity
Concept and Options
Dr Vinod Nikhra
M.D., ICCN, PGCHM, FIMSA
Fellow Royal Society of Medicine
Bansal Multispeciality Hospital, Bhopal
8 December 2023
The Life Course
All Life-forms in the Universe pass through:
Birth – Growth – Aging – Death
And the Human Life is
No Exception.
Human Life
Life course and Life span
Developmental deficits at birth
Health - challenges and events
Longevity – QOL, Will-to-survive
Longevity views
Life should be Big
.. Not Long
The Life should be
Big and Long
The Life
should be
Healthy and
Long enough for
Fulfilment
Human Lifespan
*जीवेम शरदः शतम्।
(शुक्ल यजुवेद Chapter 36 मंञ 24)
Wishing a life of hundred years
*May you live until 120
- The Jewish toast to long life
*Sporadic cases of longer life
- Jeanne Louise Calment 122y 164d
Options for Longevity
Tracks –
*Normal Longevity
*Extreme Longevity
*Living forever
Achieving Normal Longevity
1. Retarding aging process
- Lifestyle and CR/CRAN
- Anti-oxidants
- Anti-aging formulations
2. Renewal of aging organs
- Allografts, Xenografts
- 3D Bioprinting
Life Extension Program (LEP)
- Can be seen as a plausible step in near future.
Step One: Taking advantage of existing knowledge for
slowing aging through interventions like CR, antioxidants
Step Two: Utilizing the advances in genetic engineering
including stem cell and biotechnology
Step Three: Use of future nanotechnology and artificial
intelligence revolution to repair mutations and other
defects due to aging at molecular and cellular
levels
- It is projected to go through three steps -
- Cryonics is practice of freezing a body immediately
after clinical death – Cryopreservation.
- It is speculative life support science that seeks to
preserve human life in a state that will be viable and
treatable by future medical advances.
- The concept is based on sophisticated understanding
of death called ‘information-theoretic death’ which
offers bridge to life in future.
The Suspended Life and Revival
Concepts for Cryonics - Clinical-Legal and Information-Theoretic Death
- The current medical and legal definition of death is
based on the cardiac arrest and the cessation of
electrical activity in the cerebral cortex.
- Whereas a person is dead according to information
theoretic criterion if memories, personality, and psyche
are destroyed, and the brain micro-structures encoding
memory and personality are so disrupted that it is no
longer possible to recover them.
- Thus, information-theoretic death is ‘absolute
irreversible death’ and not the
clinical death.
The cryopreservation in action
- The cryopreserved bodies are not irreversibly dead
as per the information-theoretic definition of death.
- They are kept indefinitely preserved in Dewar flask
filled with liquid N2 for anticipated damage reversal
in near future.
- The revival will be possible with future science
and technologies allowing cause of fatality to be
cured and repair organ damage due to aging
process.
Cryopreservation facilities -
- Cryonics Institute
‘A Second Chance at Life’
EMAIL: INFO@CRYONICS.ORG
- Alcor Life Extension Foundation
World’s Leader in Cryonics Est.1972
Scottsdale, AZ 85260
- KrioRus, Brain Preservation Foundation,
American Cryonics Society, Life Extension
Society, etc.
Achieving Longevity
Final Tracks and Projections
Future Projections for Exponential Longevity, Damage repair, Rejuvenation and Revival
The Evolving Medical Science and Technologies
LinkedIn
Longevity
Research Group
Longevity.Technology
and other such projects
Discover the Latest Breakthroughs
in Aging Research
The Future of Immortality:
Remaking Life and Death in Contemporary Russia
by –
Anya Bernstein
Published by:
Princeton University Press
https://doi.org/10.2307/j.ctvc77d3d
https://www.jstor.org/stable/j.ctvc77d3d
The Ultimate Aims of Aging Research
*Achieve healthy longevity
*Do away with Death
*Find ways to live forever.
Let us celebrate life!
Let us join this journey.
Thank you,
So much!

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Human Longevity - Concepts and Options - Vinod Nikhra - 08 Dec 2023.pdf

  • 1. Human Longevity Concept and Options Dr Vinod Nikhra M.D., ICCN, PGCHM, FIMSA Fellow Royal Society of Medicine Bansal Multispeciality Hospital, Bhopal 8 December 2023
  • 2. The Life Course All Life-forms in the Universe pass through: Birth – Growth – Aging – Death And the Human Life is No Exception.
  • 3. Human Life Life course and Life span Developmental deficits at birth Health - challenges and events Longevity – QOL, Will-to-survive
  • 5. Life should be Big .. Not Long
  • 6. The Life should be Big and Long
  • 7. The Life should be Healthy and Long enough for Fulfilment
  • 8. Human Lifespan *जीवेम शरदः शतम्। (शुक्ल यजुवेद Chapter 36 मंञ 24) Wishing a life of hundred years *May you live until 120 - The Jewish toast to long life *Sporadic cases of longer life - Jeanne Louise Calment 122y 164d
  • 9. Options for Longevity Tracks – *Normal Longevity *Extreme Longevity *Living forever
  • 10. Achieving Normal Longevity 1. Retarding aging process - Lifestyle and CR/CRAN - Anti-oxidants - Anti-aging formulations 2. Renewal of aging organs - Allografts, Xenografts - 3D Bioprinting
  • 11. Life Extension Program (LEP) - Can be seen as a plausible step in near future. Step One: Taking advantage of existing knowledge for slowing aging through interventions like CR, antioxidants Step Two: Utilizing the advances in genetic engineering including stem cell and biotechnology Step Three: Use of future nanotechnology and artificial intelligence revolution to repair mutations and other defects due to aging at molecular and cellular levels - It is projected to go through three steps -
  • 12. - Cryonics is practice of freezing a body immediately after clinical death – Cryopreservation. - It is speculative life support science that seeks to preserve human life in a state that will be viable and treatable by future medical advances. - The concept is based on sophisticated understanding of death called ‘information-theoretic death’ which offers bridge to life in future. The Suspended Life and Revival
  • 13. Concepts for Cryonics - Clinical-Legal and Information-Theoretic Death
  • 14. - The current medical and legal definition of death is based on the cardiac arrest and the cessation of electrical activity in the cerebral cortex. - Whereas a person is dead according to information theoretic criterion if memories, personality, and psyche are destroyed, and the brain micro-structures encoding memory and personality are so disrupted that it is no longer possible to recover them. - Thus, information-theoretic death is ‘absolute irreversible death’ and not the clinical death.
  • 16. - The cryopreserved bodies are not irreversibly dead as per the information-theoretic definition of death. - They are kept indefinitely preserved in Dewar flask filled with liquid N2 for anticipated damage reversal in near future. - The revival will be possible with future science and technologies allowing cause of fatality to be cured and repair organ damage due to aging process.
  • 17. Cryopreservation facilities - - Cryonics Institute ‘A Second Chance at Life’ EMAIL: INFO@CRYONICS.ORG - Alcor Life Extension Foundation World’s Leader in Cryonics Est.1972 Scottsdale, AZ 85260 - KrioRus, Brain Preservation Foundation, American Cryonics Society, Life Extension Society, etc.
  • 19. Future Projections for Exponential Longevity, Damage repair, Rejuvenation and Revival
  • 20. The Evolving Medical Science and Technologies
  • 21.
  • 22. LinkedIn Longevity Research Group Longevity.Technology and other such projects Discover the Latest Breakthroughs in Aging Research
  • 23. The Future of Immortality: Remaking Life and Death in Contemporary Russia by – Anya Bernstein Published by: Princeton University Press https://doi.org/10.2307/j.ctvc77d3d https://www.jstor.org/stable/j.ctvc77d3d
  • 24. The Ultimate Aims of Aging Research *Achieve healthy longevity *Do away with Death *Find ways to live forever.
  • 25. Let us celebrate life! Let us join this journey.