1. What advancements in longevity
science mean for individuals, society,
the economy and the military
The Longevity Dividend:
Lydia Kostopoulos, PhD
Senior Strategy & Emerging Technologies Advisor
LKCYBER.COM
Prepared for the
September 7th, 2023

2. ABSTRACT
The Longevity Dividend: What advancements
in longevity science mean for individuals,
society, the economy and the military
The information theory of biology has
accelerated scientific knowledge of the inner
workings of our bodies – understanding them
from an almost machine and code perspective.
Advancements in gene therapy, cellular
rejuvenation and the longevity science field is
growing exponentially and many experts in the
field are claiming we now live between mortals
and immortals. Renown technologist Ray
Kurzweil predicts that we will reach longevity
escape velocity by 2029. This would mark a
moment when technological improvements add
years to life faster than time passes. This
presentation explores what these
advancements mean for individuals, society, the
economy and the military.
The Longevity Dividend:

3. 01.
02.
03.
You are Here
Current state of medicine
and longevity.
About
Lydia Kostopoulos, PhD
Unsustainable Costs of Illness
Reasons you should care about the
social and economic costs of chronic
disease and illness.
Table of
Contents
04.
05.
06.
Industrial Base
Securing and protecting the
industrial base of the future.
The Longevity Dividend
The opportunities of a longer
healthspan.
Human Prosperity
An unparalleled opportunity to
move our species forward.

4. 01.
About
Lydia Kostopoulos, PhD
Senior Strategy & Emerging Technologies Advisor

5. Lydia Kostopoulos, PhD
Dr. Kostopoulos is a senior strategy and emerging
technologies innovation advisor. Her emerging
technologies expertise has been sought by the United
Nations, US Special Operations, US Secret Service, Foreign
Governments, MIT Lincoln Labs, NATO, IEEE Standards
Association, management consultancies, industry and
academia. Her experience spans countries and continents
where she has worked in US, Europe, Middle East and East
Asia.
Passionate about the future of being human, her
Nof1 Longevity project explores stories of individuals who
are intentionally and proactively on a journey to longevity.
www.nof1project.com
Bilingual: English & Spanish

6. 02.
You are here
Current state of medicine and longevity.

7. Biological
aging is
irreversible.
TODAY

8. A Tiny Glance at Aging Today
30s
60s
40s
70s
50s
80s
Bone and
Muscle
mass start to
decline
Muscles
are less
flexible Metabolism starts
to slow down
At 35
2/3rds of men
experience
hair loss
Starting in the 20s people
can lose 1/4th to 1/2 an
inch of height per decade
Sedentary life furthers
muscle mass decline
Recognizing emotions
increases, while there is a
slight decline in memory
and reasoning.
Source: Adapted from https://www.deseret.com/2016/10/7/20597760/what-70-really-looks-like-and-30-and-40-and-50
Neurons shrink and have fewer
connections resulting in brain function
decline affecting memory
Metabolism more
notably slows down
Eyes become sensitive to
glare and night vision
becomes challenging
1/4 of women
develop a thyroid
condition
1/3rd have
hearing loss
Larynx begins
to weaken
taste buds
shrink
70% will
have
cataracts
after 75
vision,
hearing
and smell
erode
50% have
arthritis
aches
85% have chronic
conditions
managed by
prescription drugs
1/3rd over 85 will
develop Alzheimer's
1/3rd will experience
incontinence
33% find it difficult to
walk & 25% struggle
to get out of a chair

9. Hallmarks of Aging

10. mRNA Therapy
Cellular Reprogramming
Ground breaking research today
CRISPR
Gene Therapy

11. Biological
aging is
reversible.
FUTURE

12. 03. Unsustainable Cost of Illness
Reasons you should care about the social and economic costs of
chronic disease and illness.

13. Chronic Disease: State of Affairs
TODAY
Source: https://www.cdc.gov/chronicdisease/resources/infographic/chronic-diseases.htm

14. “Our epidemic of
loneliness and
isolation has been an
underappreciated
public health crisis
that has harmed
individual and
societal health."
U.S. Surgeon General Dr. Vivek Murthy

15. Managing Mental
& Emotional Health
29% increased risk of heart disease,
32% increased risk of stroke, and
50% increased risk of developing dementia for older adults.
The physical health consequences of poor or insufficient
connection include a
Additionally, lacking social connection increases risk of
premature death by more than 60%.
Source: https://www.hhs.gov/about/news/2023/05/03/new-surgeon-general-advisory-raises-alarm-about-devastating-impact-epidemic-
loneliness-isolation-united-states.html

16. Chronic Disease: The Cost
TODAY
Source: https://www.cdc.gov/chronicdisease/resources/infographic/chronic-diseases.htm

17. $37 trillion
Annual cost of chronic illness to the American Population (2022)

18. Annual cost of chronic illness to the American Population (2022)
$37 trillion
19% of US GDP

19. Where do
we stand?
Source: https://www.cms.gov/Research-Statistics-
Data-and-Systems/Statistics-Trends-and-
Reports/NationalHealthExpendData/NHE-Fact-Sheet

20. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664600/

21. Longevity as a part of
Economic Prosperity
FUTURE

22. 02.
The Longevity Dividend
The opportunities of a longer healthspan.

23. Healthspan -vs- Lifespan

24. Historical Comparison

25. US Lifespan Today

26. A Declining Population

27. Public Health
is Reactive
TODAY

28. Public Health
is Proactive
FUTURE

29. Objective:
Socially &
economically
prosperous nation

30. The Gaps that
extending healthspan
and longevity can fill
ECONOMIC
PUBLIC
MILITARY

31. 2035
FEDERAL FUNDING
NEEDS

32. $31.4 TRILLION
NATIONAL DEBT AS OF 2023
$50 TRILLION
PROJECTED DEBT IN 2033
ECONOMIC
NEEDS

33. Recruitment and
Retention Gaps
MILITARY
NEEDS

34. How?
A vision for protecting and preserving healthspan through emerging
technology and proactive next generation preventative public health.
Gene Therapy
Maintain
cognitive,
muscular and
cellular health
mRNA
Therapy
Targeted
disease
reversal and
prevention
Cellular
Rejuvenation
Reversing cellular
malfunction w/cellular
reprogramming
and epigenetic
regulation.
Tissue/Organ
Engineering
Research to
solve for organ
shortage.
Advanced
Diagnostics
Helping treat
illness at the
nascent stage.

35. Invest resources & create
laws/incentives to protect
and bolster chemical
manufacturing.
What the
government
should do
Open the pharmaceutical
possibilities for
preventative health.
Currently vaccines are the
only permitted form of
pharmaceutical preventative
health. This discourages
industry from developing
gene and mRNA related
preventative therapies.
Increase government
clinical trial approval
resources so more can take
place quicker.
If the US is to make clinical
advancements in next
generation therapies and
reverse aging more clinical
trials are needed.
Create more 'Right to Try' Pathways
For those with informed consent who want to try these new
therapies in the US instead of flying to a foreign country.
Identify aging as a disease.
This will allow for more research and pharmaceutical
funds to be dedicated to the problem.

36. 05.
Industrial Base
Securing and protecting the industrial base of the future.

37. URGENT need to scale
up chemical
manufacturing and
protect raw materials
supply chain resources

38. Challenges to
Scale Chemical
Manufacturing
Pandemic
COVID made prices go up to
support vaccine manufacturing.
Geopolitics
Geopolitical competition for
supply chain resources.
Climate Change
Climate change affecting
raw resources.

39. 06.
Human Prosperity
An unparalleled opportunity to move our species forward.

40. 100 is the new 60

41. What a longer healthspan looks like today
Fitness Influencer inspiring others at 76
Fashion Icon and
Business Woman at 102
Iris Apfel
'Train with Joan'

42. What a longer healthspan looks like today
#1 Global Conservationist Leader (89)
Jane Goodall
Career change at 70 from Corporate
Executive to Film Producer

43. What a longer healthspan looks like today
Running a Business Empire and a
Sports Illustrated Cover Model at 82
"over 80 for Brady" Sports fan
club, friendship and community

44. What a longer healthspan looks like today
In 2014 Yuichiro Miura became the
oldest person to reach the top of
Mount Everest at age 80 and he
would like to try again at age 90.
Vito Perillo won his first-ever election at
93 and re-elected at 97. Currently
serving as Major of Tinton Falls, NJ

45. Technological
advancements
can help
everyone live
life to the fullest
with maximum
healthspan.

46. Citizens of the most
forward leaning
governments will
be the first to
experience what a
pain free and
disease free older
age can feel like.

47. Once in a lifetime opportunity.
species

48. But first, we need to recognize
aging as a disease.

49. And healthspan a national priority.

50. Neom 7 Pillar Framework:
World 1st
First government-led smart city that prioritizes
healthy human longevity as an explicit goal and asset.
SAUDI ARABIA
1. HUMAN-CENTRIC: We focus on our senior citizens by truly understanding and anticipating their
needs, expanding their interests and by innovating in an advanced service provision.
2. REJUVENATED: We multiply mental and physical health benefits of our seniors by applying latest
research, technologies and alternative methodologies which transform aging into healthy longevity.
3. THOUGHTFUL: We reinvent the tribal elder system by strengthening community governance
across generations, by increasing transgenerational knowledge exchange, long-termism and wisdom
through open education, lifelong learning and volunteering;
4. INTERCONNECTED: We increase connectedness and belonging by providing a physical and
virtual environment that fosters intra- and intergenerational social inclusion and participation for our
seniors;
5. RESPONSIBLE: We support our seniors to conserve and regenerate natural resources by
providing carbon-positive, green, circular, resilient and affordable solutions and physical assets
which will outperform the Sustainable Development Goals;
6. TRANSCENDENTAL: We help our seniors to maintain purpose and meaning in life through a path
of ethics, philosophy and spirituality; and
7. PROTECTED: We assure our seniors to feel safe and we help protect their financial resources and
assets by reducing risks and deploying tangible solutions that prevent harm or value loss, and by
promoting a responsible governance of the community’s assets to drive long-term value also for
future generations.

51. Hevolution Foundation: $Billions Investment

52. PREPARE FOR
LABOR SHORTAGE
ADVOCATE FOR
LONGEVITY POLICY
DEVELOP A
LONGEVITY STRATEGY
Map organizational talent
demographics to future needs.
Leverage artificial intelligence where
possible to automate workflows and
reduce human resource needs so free
up human talent to work on uniquely
human aspects of the business.
Take an inventory of single points of
"talent" failure due to retirement and
create knowledge transfer strategies.
Create health policies that enable
talent to perform their best for as long
as they want to work. This includes
more vacation and shorter work days.
advocate for longevity minded
strategies within and across
government agencies.
spread awareness on the urgency of
longevity related public health and
regulatory policies.
reach out to legislative
representatives to discuss the
importance of creating legislation
that enables a medical environment
where longevity treatments are
available.
Within the realm of your authority and
perspective:
How to manage risk due to employee
illness.
How to encourage a longevity and
healthspan minded organization.
Health benefits to support employee
healthspan and longevity.
Non-health benefits that support
employee healthspan and longevity.
Develop an organizational longevity
strategy that includes the following
considerations:
Nationwide: Develop a framework for a
longevity strategy tailored to the US
context and needs.
Top Recommendations for Federal Foresight Professionals

53. The Nof1 interview series features stories
of people who have taken it upon
themselves to proactively plan their
heathy aging routines and create their own
health plans using wearables, resources
and the help of various professionals.
You can sign up to be notified when the
series comes out here:
nof1project.com

54. Lydia Kostopoulos, PhD
Lkcyber.com
@LKCYBER
Reach out!