The significant protective association between higher blood product ratios and mortality that we observed was concentrated in the first 24 hours for plasma and the first 6 hours for platelets. Thereafter, during the later time periods of high competing risks for nonhemorrhagic causes of death among severely injured patients, plasma and platelet ratios were not significantly associated with mortality.
The Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study demonstrated that clinicians generally were transfusing patients with a blood product ratio of 1:1:1 or 1:1:2 and that early transfusion of plasma (within minutes of arrival to a trauma center) was associated with improved 6-hour survival after admission.
The significant protective association between higher blood product ratios and mortality that we observed was concentrated in the first 24 hours for plasma and the first 6 hours for platelets. Thereafter, during the later time periods of high competing risks for nonhemorrhagic causes of death among severely injured patients, plasma and platelet ratios were not significantly associated with mortality.