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BearingtheBurden
Health Implications of
Environmental Pollutants in Our Bodies
Health Implications of
Environmental Pollutants in Our Bodies
January 2003
Physicians for Social Responsibility
BearingtheBurden
www.envirohealthaction.org/bearingtheburden 3
EXECUTIVESUMMARY
P
hysicians for Social Responsibility (PSR) has a
longstanding commitment to informing the
publicaboutenvironmentalhazardstohuman
health. Primary hazards of concern are chemicals
that contaminate the food we eat, air we breathe,
and water we drink. When new scientific data
emerge about toxic substances in the environment,
PSRiscommittedtohelpinterpretthefindingsand
make them available to the public.
This summary document includes back-
ground information to assist the American pub-
lic in understanding the results of the 2003 Na-
tional Report on Human Exposure to Environ-
mental Chemicals (referred to here as the Na-
tional Exposure Report) developed by the Cen-
ters for Disease Control and Prevention (CDC).
PSR’s full report also includes information about
the chemical types in the 2003 National Expo-
sure Report and, for many chemicals, detailed
profiles describing potential sources of exposure,
health effects, methods for detecting exposure,
and federal regulations for protecting human
health. The full report is available at www.enviro
healthaction.org/bearingtheburden.
This report does not include chemical-specific
biomonitoring data from the National Exposure
Report. To obtain a copy of CDC’s report, visit
CDC’s web site at http://www.cdc.gov/exposure
report or call CDC’s National Center for Envi-
ronmental Health at 1-866-670-6052.
WHAT IS THE CDC NATIONAL
EXPOSURE REPORT?
In 2001, CDC presented the groundbreaking re-
sults of a new study describing the exposure of
theAmerican public to environmental pollutants.
This CDC study was the first in a series of annual
reports that is the most comprehensive assess-
ment of its kind. It tries to identify exposures to
specific toxic chemicals in the U.S. population. It
estimates the degree of exposure by measuring
amounts of those pollutants in the body. These
data are gathered through biological monitoring,
or biomonitoring, in which samples of urine or
blood are collected from members of the popu-
lation and analyzed for specific chemicals. (Refer
to the following section for more information about
biomonitoring.)
The National Exposure Report presents bio-
monitoring data for a representative cross-section
of the American population, made up of several
thousand people from across the country. These
data are part of a larger study called the National
The full report with chemical profiles is available at
www.envirohealthaction.org/bearingtheburden.
4 www.envirohealthaction.org/bearingtheburden
Bearing the Burden
Health and Nutrition Examination Survey, or
NHANES, in which volunteers are examined for
a broad range of health measures. Among other
tests, NHANES participants provide blood and
urine that are tested for specific environmental
chemicals. Study participants are selected from
15 different geographic regions of the U.S. and
represent different segments of the population,
including African Americans, Mexican Ameri-
cans,adolescents,pregnant women,children,and
the elderly.
The first National Exposure Report included
biomonitoring data for 27 different environmen-
tal chemicals,including heavy metals,certain pes-
ticides, and phthalates (chemicals used to make
plastics, cosmetics, and other products). In 2001,
CDC committed to adding new chemicals in sub-
sequent reports. In the 2003 National Exposure
Report, CDC presents findings for more than 100
different environmental chemicals. This latest re-
port includes many new chemicals and chemical
types not addressed in the first report, including
persistent organochlorine pesticides, herbicides,
fungicides, pest repellents, carbamate pesticides,
polychlorinated biphenyls (PCBs), dioxins, and a
class of chemicals called polycyclic aromatic hy-
drocarbons(PAHs).Thesechemicalsaredescribed
in more detail in the full online report. Improve-
ments in measuring chemicals should allow more
to be monitored in coming years.
Inthe2003report,CDChascombinedthedata
from the 1999 NHANES (presented in the 2001
National Exposure Report) with data from the
current survey to develop a baseline of environ-
mental chemical exposures. This baseline will be
compared with results of future analyses and will
beusefulinidentifyinggeneraltrendsinexposures
acrossthepopulationandwithinsubgroupsof the
population.Thesebaselinedatawillalsohelpphy-
sicians interpret the results of biological sampling
on patients and will help health scientists priori-
tize needs for research on exposure and health ef-
fects of chemicals of concern.
WHAT DOES THE NATIONAL
EXPOSURE REPORT TELL US?
The overall purpose of the National Exposure Re-
port is to provide a “snapshot” of the types and
amounts of environmental chemical exposures in
theU.S.population.Physicians,scientists,andpub-
lic health officials can use the information to pre-
ventdiseasesthatmightbecausedbyenvironmen-
tal contaminants. While the study tries to repre-
sent a large part of the U.S. population, a particu-
lar person’s exposure to environmental chemicals
may be very different from the sample in the re-
port.Individualexposuresmaybehigherorlower,
dependingonfactorssuchasdiet,age,occupation,
chemical use, and many other variables.
In general,the amount of a chemical measured
in blood or urine reflects the amount of a person’s
exposure to that chemical.However,some chemi-
cals are rapidly broken down by the body and can
be eliminated within hours or days following ex-
posure. This makes them more difficult to detect
throughrandomtesting.Ontheotherhand,more
persistent chemicals (e.g., certain pesticides, di-
oxins, and PCBs) are not readily broken down
and can be stored in fatty tissues and organs for
many years.In such cases,levels in blood or urine
may reflect only a fraction of the total amount of
stored chemical in the body (called body burden).
It is therefore important that the chemical levels
presented in the National Exposure Report be
interpreted with care and that they be used as
broad indicators of exposure rather than exact
measurements.
www.envirohealthaction.org/bearingtheburden 5
Health Implications of Environmental Pollutants in Our Bodies
The National Exposure Report does not mea-
suretheriskof diseasefromenvironmentalchemi-
cal exposures, nor does it relate chemical levels in
the body to disease. Information on body burden
of pollutants provided by CDC’s biomonitoring
study is only one piece of the puzzle. There are
more than 70,000 industrial chemicals registered
for use in the U.S today. For the vast majority of
these chemicals, scientists know little or nothing
about releases to the environment, levels of hu-
man exposure,or long-term effects on health.For
manyenvironmentalpollutants,scientistsareonly
beginning to understand how levels of pollutants
in the body relate to health effects and disease.We
have an incomplete picture of the various chemi-
cal contaminants in our food, water, and air. We
need to learn much more about how people are
exposed and how chemicals are broken down or
stored by the human body.These are critical miss-
ing links in our understanding, and they are the
focusof intensivestudybyhealthresearchers.This
information is important for all Americans, but
particularly for those individuals who may be es-
pecially vulnerable to the effects of certain chemi-
cals. These include infants, young children, and
pregnant women.
WHAT IS BIOMONITORING?
Biological monitoring, or biomonitoring, is de-
fined as the measurement of toxic substances in
the body.Scientists can analyze samples of urine,
serum, saliva, blood, breast milk, and other tis-
sues (such as body fat and teeth) to measure the
levels of various chemicals in the body.
Biomonitoring can show whether and how much
an individual or population has been exposed to
a chemical.When combined with efforts to track
disease patterns, this information can be helpful
in determining whether chemical exposures are
causing illness and may aid in deciding what type
of medical treatment is needed. Biomonitoring
is also a valuable tool in disease prevention. Early
detection of chemical exposure, followed by
prompt and appropriate intervention to limit or
stop the exposure, can help prevent illness from
occurring.
While biomonitoring is not a new concept,the
CDC’s effort is the most intensive and compre-
hensive so far, aimed at measuring the types and
amounts of environmental pollutants and other
toxic chemicals Americans have in their bodies.
Together with other environmental databases (re-
porting, for example, chemical releases to air or
water), this effort is an important step in under-
standing our exposure to toxic chemicals in the
environment and finding ways to reduce and ul-
timately eliminate our exposure to environmen-
tal pollutants.
WHAT CHEMICALS DID
CDC MEASURE THIS YEAR?
In its 2001 report,CDC presented biomonitoring
data that demonstrated exposure to 27 environ-
mental chemicals—heavy metals, breakdown
products (metabolites) of organophosphate pes-
ticides, phthalates (chemicals used to make plas-
tics, cosmetics, and other products), and one in-
door air pollutant (cotinine, which represents
exposure to tobacco smoke).
The2003NationalExposureReportincludesthe
samechemicalsreportedbyCDCin2001andmany
new ones. The following table summarizes the en-
vironmental chemicals addressed in the current
Report and the most common ways humans are
exposed.An asterisk (*) indicates that the chemical
class was also included in the first Report.
6 www.envirohealthaction.org/bearingtheburden
Bearing the Burden
Chemical class Examples Primary Exposure Routes
HEAVY METALS * Chromium, lead, Foods with pesticide or fertilizer residue;
mercury contaminated air/water/soil, especially in
vicinity of hazardous waste or other
industrial sites
PHTHALATES * DEHP, DEP, DBP Cosmetics; contaminated food; some PVC
plastic products; contaminated air/water/soil,
especially in vicinity of hazardous waste or
other industrial sites
PESTICIDES
Non-persistent
Pesticides
• Organophosphate Diazinon, malathion Foods (especially fruits and vegetables)
pesticides * contaminated with pesticide residues; lawns
and gardens; contaminated indoor dust
• Carbamate pesticides Aldicarb (Temik), Residues on crop foods; lawns and gardens;
carbaryl (Sevin), flea/tick repellents
propoxur (Baygon)
Persistent Pesticides
• Organochlorine DDT, aldrin, dieldrin, Fatty foods (primarily fish, meat, dairy, eggs)
pesticides chlordane
PEST REPELLENTS DEET Repellent products applied directly to skin
FUNGICIDES Ortho-phenylphenol Residential insecticides and disinfectants
HERBICIDES 2,4-D, alachlor, Foods; contaminated water; residential plant
atrazine growth regulators
DIOXINS 2,3,7,8-TCDD, many Fatty foods (primarily fish, meat, dairy, eggs);
other forms contaminated soil/sediment, especially in
vicinity of incinerators, hazardous waste, or
other industrial sites
POLYCHLORINATED Many different forms Fatty foods (primarily fish, meat, eggs, dairy,
BIPHENYLS (PCBs) processed food); contaminated soil/sediment,
especially in vicinity of hazardous waste or
other industrial sites
POLYCYCLIC AROMATIC Benzo[a]pyrene, Tobacco or wood smoke; fossil fuel
HYDROCARBONS (PAHs) 1-benzo[a]anthracene combustion products; grilled foods;
contaminated ambient air; dairy foods
COTININE * — Tobacco products or second-hand tobacco
smoke
www.envirohealthaction.org/bearingtheburden 7
Health Implications of Environmental Pollutants in Our Bodies
WHAT HAPPENS TO
POLLUTANTS IN THE BODY?
The effect of chemicals on the body depends on
a number of different factors. Chemical-specific
properties, the amount, duration, and timing of
exposure, the route of exposure (e.g., eating/
drinking, breathing, skin contact), and an
individual’s genetic makeup affect how a chemi-
cal behaves in the body and its toxic effects. A
discussion of these complex factors and their in-
teractions is beyond the scope of this document.
Rather,this section focuses on some key concepts
to help understand biomonitoring data.
Biomonitoring studies are designed to recog-
nize the unique behavior of each chemical in the
body.This knowledge is used to determine which
body tissues and fluids should be sampled and
which specific chemical markers should be mea-
sured. Some chemicals, such as heavy metals and
certain pesticides, are toxic without breaking
down in the body and are excreted practically
unchanged. These chemicals can be measured
directly in the blood or urine. Other chemicals,
such as organophosphate and carbamate pesti-
cides, are partially or totally broken down in the
body, forming new chemicals called metabolites.
These metabolites can then be measured in blood
or urine. Some metabolites are unique, in that
they are formed from one specific parent com-
pound. Measurements of such metabolites are
highly useful in confirming exposure to specific
chemical pollutants.Other metabolites,however,
can have multiple sources and are less specific
indicators of exposure. For example, dimethyl-
phosphate is a metabolite of more than a dozen
different organophosphate pesticides. Without
more specific chemical markers, biomonitoring
studies can only broadly show possible exposure
to a chemical or class of chemicals.
Finally, certain chemicals or metabolites may
be stored in various tissues of the body, such as
fat,organs,blood,hair,bones,orteeth.Theamount
of stored chemical in the body is referred to as the
bodyburden.Itisimportanttoknowwhichchemi-
calsarestoredinthebodybecausetheyareasource
for continued exposure with potentially serious
healthconsequences.Somechemicals,whenstored
in the body for prolonged periods, can increase
the potential for disease to occur.
For more information, refer to the National Insti-
tutes of Health, National Library of Medicine
(NLM) web site on Toxicology and Environmental
Health, found at http://sis.nlm.nih.gov/Tox/
ToxMain.html.
WHAT IS THE DIFFERENCE
BETWEEN “ACUTE” AND “CHRONIC”
EXPOSURES AND EFFECTS?
The terms acute and chronic are often used to de-
scribe types of chemical exposure or the health
effects resulting from such exposure. These are
termsthatyouwillseeusedfrequentlyintheonline
chemicalsummaries.Theyapplytothetimingand
not the severity of the exposure.An acute exposure
refers to an exposure that occurs over a short pe-
riod or in a single dose. An acute effect is one that
occurs within a short time (often hours or days)
following a brief exposure. Acute exposures (and
effects) are more typical in the workplace or from
accidental poisonings. The term chronic exposure
refers to a chemical exposure that occurs repeat-
edly over a long period (months or years) and of-
ten at low concentrations. Chronic, low-level ex-
posures are much more common in everyday life
than acute, high-level exposures. Most people en-
counter low levels of many different chemicals
8 www.envirohealthaction.org/bearingtheburden
Bearing the Burden
throughtheireverydayactivities.Thisexposurecan
continue undetected for days, months, or years.
Exposures to pollutants are most often chronic
exposures with long-term health effects.A chronic
effect is one that shows up a long time after expo-
sure or that results from a long-term exposure. It
is important to recognize that acute exposures can
have both acute and chronic health effects.
When a chemical is first studied,research tends
to focus on acute health effects.Chronic health ef-
fects (cancer, for instance) studies are expensive
and time-consuming and are therefore available
for only a fraction of the toxic chemicals in use.
For these reasons, our understanding of the
chronic health effects of many chemicals is lim-
ited.Inrecentyears,however,researchhasfocused
more on long-term, chronic effects of chemical
exposures. As a result of this research, scientists
are discovering effects on the developing fetus,ef-
fects on brain and nervous system development,
and disruption of the human hormonal and re-
productive systems. For example, animal studies
have shownthatcertainpesticidescandamagethe
brain,producingasyndromesimilartoParkinson’s
disease. These findings support growing evidence
that pesticide exposure, including in-home expo-
sure, might contribute to the development of
Parkinson’s disease in humans.
Because most people in the U.S. are mostly ex-
posed to low levels of chemicals over long periods
of time, the data in the National Exposure Report
reflect such exposures, rather than acute or high-
levelexposures.Similarly,thesummariespresented
in this report online focus on chronic health ef-
fects and effects of low-level exposure, where we
know or have good reason to suspect them.While
the health effects information presented here is
drawn from the most authoritative sources avail-
able, including Environmental Protection Agency
(EPA) and CDC, new information on chemical
health effects is becoming available almost daily.
Consequently,the profiles maynotincludeallthat
iscurrentlyknownaboutthesechemicalsandmay,
in fact, understate potential health consequences
of long-term exposures.
REGULATORY PROGRAMS FOR
PROTECTION OF PUBLIC HEALTH
FROM CHEMICAL EXPOSURES
The federal government has a variety of regula-
toryprogramsintendedtoreduceexposuretotoxic
substances to workers and the general public. For
some chemicals, there are enforceable maximum
levels of pollutants in air, industrial emissions,
drinking water,food products,and workplace set-
tings. However, as CDC’s National Exposure Re-
port shows, the public is exposed to a variety of
pollutants in spite of these regulations.
Biomonitoringdatafromthisandfutureyearsmay
ultimatelyprovehelpfulinidentifyingcriticalgaps
and shortcomings in the laws and regulations de-
signed to prevent or minimize such exposures.
The chemical profiles at www.envirohealth
action.org/bearingtheburdenidentifyspecificfed-
eral standards, where they exist. It is important to
note that allowable levels of chemicals in the envi-
ronment and the workplace are not comparable
to the levels that CDC has measured in human
bloodandurinesamples.So-called“legally”safelev-
els of human exposure have not been determined
for many chemicals. But for some chemicals, there
may be no safe level of exposure, especially for vul-
nerable people like pregnant women and young
children. The regulations and standards presented
here are listed for the purpose of showing where
efforts to limit human exposures exist.
www.envirohealthaction.org/bearingtheburden 9
Health Implications of Environmental Pollutants in Our Bodies
Drinking Water Standards
The Safe Drinking Water Act (SDWA) authorizes
EPA to establish allowable levels of contaminants
in public drinking water supplies. The National
Primary Drinking Water Standards are intended
to protect consumers from adverse health effects
of contaminants in public water systems.Enforce-
able standards, called Maximum Contaminant
Levels (MCLs), have been established for a num-
berof contaminants,includingmanyof thechemi-
calsaddressedinCDC’sNationalExposureReport.
Public water systems are required to meet these
standards through drinking water treatment or
othertechniques.Inspiteof EPA’sregulations,test-
ing has shown that allowable levels of many con-
taminants are frequently exceeded in some public
drinkingwatersupplies.Furthermore,privatewells
are not tested for contaminants,and EPA does not
regulate the quality of water from such wells.
MCLs,expressedasmilligramsof contaminantper
liter of water, or mg/L, are cited in the chemical
profiles, if applicable.
For more information about EPA drinking water
programs, refer to http://www.epa.gov/safewater/.
A list of current federal drinking water standards
and health advisories is available online at http://
www.epa.gov/ost/drinking/standards/dwstandards.pdf.
Air Quality Standards
The Clean Air Act is the main law for protecting
Americans from air pollutants. Under this law,
EPA requires the reduction of emissions of vari-
ous types of air pollutants. For example, EPA is
required to establish NationalAmbient Air Qual-
ity Standards for six of the most common air
pollutants in the U.S. (so-called “criteria air pol-
lutants”), one of which is lead, a chemical in-
cluded in CDC’s National Exposure Report.1
In
addition, EPA has taken steps to protect the pub-
lic from other air pollutants that are known or
suspected to cause cancer and other serious health
effects, including many of the pollutants ad-
dressed by CDC. Ways these pollutants are re-
duced include controls on industrial sources and
vehicle emissions and reductions of levels in in-
door air. Despite these programs, however, air
pollution continues to pose a serious health threat
in many communities,with pollutants frequently
exceeding the national standards.
More information on criteria air pollutants is avail-
ableathttp://www.epa.gov/air/urbanair/6poll.html.
Additional details on EPA’s air toxics program can
be found in the publication “Taking Toxics Out of
the Air,” which is available online at http://
www.epa.gov/oar/oaqps/takingtoxics/.Alistof EPA-
designated hazardous air pollutants is available
onlineathttp://www.epa.gov/ttn/atw/188polls.html.
Chemical Residues in Food
The EPA,Food and Drug Administration (FDA),
and U.S. Department of Agriculture (USDA)
share responsibility for protecting consumers
from exposure to pesticides and other contami-
nants in the food supply. EPA sets limits on the
amount of pesticides that can be applied to food
crops and the levels of pesticide residues that can
remain on food when it is sold. The Food Qual-
ity Protection Act of 1996 requires the EPA to
review pesticide food residue limits (known as
“tolerances”) and consider combined exposures
1. The six pollutants are ozone, sulphur dioxide, oxides of nitrogen, lead, particulate matter, and carbon monoxide.
10 www.envirohealthaction.org/bearingtheburden
Bearing the Burden
for those pesticides that have a common mecha-
nism of toxicity,a process that has been extremely
slow. EPA is currently reviewing organophos-
phate pesticides, such as those addressed by
CDC’s National Exposure Report.FDA is respon-
sible for enforcing pesticide tolerances on all
foods except meat,poultry,and certain egg prod-
ucts, which are regulated by the USDA. FDA also
sets enforcement guidelines called“action levels”
for pesticides that are no longer allowed (such as
DDT) as well as non-pesticide contaminants (e.g.,
cadmium, lead, mercury, and PCBs) found in
food.FDA conducts annual surveys to determine
residue levels of pesticides,metals,radionuclides,
PCBs, and volatile organic compounds in the
food supply. If it finds a chemical residue higher
than allowed during these surveys, the FDA has
the authority to remove contaminated foods from
the market; however, severe limitations of the
surveys leave most foods in the U.S.untested and
restrict the FDA’s actions.
Overall,despite three federal agencies oversee-
ing food safety, harmful chemical contaminants
in food are not well monitored or regulated. In-
deed, a recent FDA study found residues of 12
persistent organic pollutants (POPs) in the aver-
age American diet. These results highlighted two
regulatory flaws. First, health limits are estab-
lished for a single chemical and not for the total
amount of similar chemicals found in the entire
diet.Second,FDA’s action levels for chemicals are
significantly higher than the health-based levels
regulated by the EPA.
For more information on FDA’s Total Diet Study,
refer to http://www.cfsan.fda.gov/~comm/tds-
toc.html. EPA publications provide more informa-
tion on regulation of pesticides in food: “Pesticides
and Food: How the Government Regulates Pesti-
cides”is available online at www.epa.gov/pesticides/
food/govt.htm, and residue tolerances for specific
foods and pesticides can be found by searching EPA’s
database at http://www.epa.gov/pesticides/food/
viewtols.htm.
Worker Protection Standards
Health-based standards to protect workers from
chemical, physical, and biological agents in the
workplace are developed by the federal Occupa-
tional Health and SafetyAdministration (OSHA).
OSHA has established maximum acceptable lev-
els (called Permissible Exposure Levels, or PELs)
for a large number of airborne chemicals found
in the workplace.The intention of PELs is to show
how much workers can be exposed to a substance
without harmful effects averaged over a normal
8-hour workday or a 40-hour week (called a time-
weighted average, or TWA). However, there is no
consensus among the occupational health com-
munity that PELs protect workers. The OSHA
standards (known as PEL-TWAs) for workplace
exposures are identified in the“Regulations”sec-
tion of each chemical profile.
The National Institute for Occupational Safety
and Health (NIOSH) and the American Confer-
ence of Governmental and Industrial Hygienists
(ACGIH), a non-government organization, have
also recommended exposure limits for many
chemicals to help protect worker health.However,
these limits are not enforceable standards and are
not cited in the chemical profiles.
The full list of OSHA standards is available online
at http://www.osha.gov/SLTC/respiratory_advisor/
advisor_genius_nrdl/z_tables.html (29CFR
1910.1000, Table Z-1 and Z-2). For more informa-
tion, on NIOSH recommendations refer to the
www.envirohealthaction.org/bearingtheburden 11
Health Implications of Environmental Pollutants in Our Bodies
NIOSH Pocket Guide to Chemical Hazards http://
www.cdc.gov/niosh/npg/npg.htmlandACGIH2002
ThresholdLimitValuesforChemicalSubstancesand
PhysicalAgents,BiologicalExposureIndicesathttp:/
/www.acgih.org/home.htm.
THE STOCKHOLM CONVENTION ON
PERSISTENT ORGANIC POLLUTANTS
Many of the chemicals addressed in CDC’s Na-
tional Exposure Report belong to a group of sub-
stancescalledpersistentorganicpollutants,orPOPs.
These chemicals are of particular public health
concern because of their high toxicity, extreme
persistence in the environment, ability to travel
long distances through air and water, and strong
tendency to accumulate in fatty tissues of animals
and humans. They bioconcenrate up the food
chain and can reach very high levels in the body
tissues of fish, predatory birds, and mammals, in-
cludinghumans.Biomonitoringstudieshavecon-
firmed that almost everyone carries traces of these
persistent chemicals in their bodies.
In the U.S., the manufacture and use of some
POPsarealreadyrestrictedorprohibited.However,
thisisnotthecaseinmanyothercountries.Because
POPs can move readily through the environment,
their continued use anywhere becomes a concern
fortheglobalcommunity.TheStockholmConven-
tion is an international treaty targeting the elimi-
nation of these toxic chemicals, beginning with 12
of the worst POPs. These are: nine pesticides (ald-
rin, chlordane, DDT, dieldrin, endrin, heptachlor,
hexachlorobenzene,mirex,andtoxaphene);thein-
dustrial chemicals hexachlorobenzene and PCBs;
andthetoxicchemicalbyproducts,polychlorinated
dioxins and furans.The Convention will also allow
countriestoacttogethertorestrictadditionalPOPs
in the future.
The Stockholm Convention was formally
adopted in May 2001 and has been signed by the
U.S. and more than 150 countries. Governments
mustnowratifytheagreement,andwhen50coun-
tries have done so, the treaty will enter into force.
FormoreinformationabouttheStockholmConven-
tion,refer to the web sites for the International POPs
Elimination Network (IPEN) at http://ipen.ecn.cz/,
the United Nations Environment Programme
(UNEP)POPswebsiteathttp://www.chem.unep.ch/
pops/, and PSR’s EnviroHealthAction web site at
http://www.envirohealthaction.org.
THE PUBLIC HEALTH
IMPLICATIONS OF THE CDC
REPORT: HEALTH TRACKING
The data in CDC’s National Exposure Report
show thatAmericans are exposed to a broad spec-
trum of potentially hazardous chemicals. These
exposures have occurred because of both current
and past contacts with chemical contaminants in
the food we eat, the air we breathe, and the water
we drink. CDC’s exposure data are significant to
our health, since they represent actual pollutants
in human body tissues and fluids. While these
data are a concern, what they mean regarding
human disease is uncertain. We do not have
enough scientific knowledge.
PSR believes the CDC biomonitoring data
present a significant public health opportunity.
Biomonitoring is an important part of under-
standing the connection between specific chemi-
cal exposure and chronic disease. EPA currently
tracks environmental hazards through its Toxic
Release Inventory, which monitors chemical re-
leases to the environment. But no comprehen-
sive system exists to collect chronic disease infor-
12 www.envirohealthaction.org/bearingtheburden
Bearing the Burden
mation. PSR recommends the creation of a na-
tionwide environmental health tracking network
to monitor and analyze data on chronic condi-
tions and their relationship to the external envi-
ronment. An effective tracking network should
include local, state, and federal public health
agencies that work together to follow the inci-
dence and prevalence of certain chronic diseases.
When combined with data from biomonitoring
and hazard tracking, the disease data will give
health practitioners and environmental regula-
tors the ability to identify disease clusters and
make informed decisions when formulating
policy that affects health.
More research is needed to understand the
health effects of the chemicals tested by the CDC.
Enough is known, though, that we should reduce
exposurethroughpollutionpreventionefforts,vig-
orousenforcementof workplaceandenvironmen-
talstandards,andpeople’spersonaleffortstoavoid
contact with hazardous substances. The chemical
information in the online report can be used by
individuals and groups as a resource for pollution
prevention programs and lifestyle choices.
THE FULL REPORT WITH CHEMICAL PROFILES IS AVAILABLE AT:
www.envirohealthaction.org/bearingtheburden.
This is a publication of Physicians for Social Responsibility. For reprint information or for additional copies,
please contact: Physicians for Social Responsibility, 1875 Connecticut Ave., NW, Suite 1012, Washington, DC 20009;
Phone: 202-667-4260; Fax: 202-667-4201; Homepage: http://www.psr.org, www.envirohealthaction.org
PHYSICIANS FOR SOCIAL RESPONSIBILITY
Robert K. Musil, PhD, MPH, Executive Director and CEO
Susan West Marmagas, MPH, Director,
Environmentand Health Program
Karen L. Perry, MPA, Deputy Director,
Environment and Health Program
Michelle Chuk, MPH, Public Health Program Director,
Environment and Health Program
Laura Rasar King, MPH, CHES, Outreach Director,
Environment and Health Program
PRIMARY CONTRIBUTORS
Carolyn Poppell, ScM
Robin Clarke, Intern, Environment and Health Program
MEDICAL AND SCIENTIFIC ADVISORS
(affiliations are listed for identification purposes only and
do not imply organizational endorsement of this publica-
tion or its content)
John M. Balbus, MD, MPH, Staff Physician,
Washington Hospital Center and
Director, Environmental Health Program,
Environmental Defense
Barry L. Johnson, PhD, FCR, U.S. Assistant
Surgeon General (Retired)
Philip J. Landrigan, MD, Chair, Department
of Community and Preventive
Medicine, Mount Sinai School of Medicine
Ted Schettler, MD, MPH, Co-chair, Human
Health and Environment Project,
Greater Boston Physicians for Social Responsibility
PHYSICIANS FOR SOCIAL RESPONSIBILITY
1875 Connecticut Avenue, NW, Suite 1012
Washington, DC 20009
US Affiliate of International Physicians
for the Prevention of Nuclear War
Copyright 2003 by Physicians for Social Responsibility. All rights
reserved. No part of this publication may be reproduced without
permission of Physicians for Social Responsibility, the U.S. Affiliate
of International Physicians for the Prevention of Nuclear War.

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Bearing the Burden - Health Implications of Environmental Pollutants in Our Bodies

  • 2.
  • 3. Health Implications of Environmental Pollutants in Our Bodies January 2003 Physicians for Social Responsibility BearingtheBurden
  • 4.
  • 5. www.envirohealthaction.org/bearingtheburden 3 EXECUTIVESUMMARY P hysicians for Social Responsibility (PSR) has a longstanding commitment to informing the publicaboutenvironmentalhazardstohuman health. Primary hazards of concern are chemicals that contaminate the food we eat, air we breathe, and water we drink. When new scientific data emerge about toxic substances in the environment, PSRiscommittedtohelpinterpretthefindingsand make them available to the public. This summary document includes back- ground information to assist the American pub- lic in understanding the results of the 2003 Na- tional Report on Human Exposure to Environ- mental Chemicals (referred to here as the Na- tional Exposure Report) developed by the Cen- ters for Disease Control and Prevention (CDC). PSR’s full report also includes information about the chemical types in the 2003 National Expo- sure Report and, for many chemicals, detailed profiles describing potential sources of exposure, health effects, methods for detecting exposure, and federal regulations for protecting human health. The full report is available at www.enviro healthaction.org/bearingtheburden. This report does not include chemical-specific biomonitoring data from the National Exposure Report. To obtain a copy of CDC’s report, visit CDC’s web site at http://www.cdc.gov/exposure report or call CDC’s National Center for Envi- ronmental Health at 1-866-670-6052. WHAT IS THE CDC NATIONAL EXPOSURE REPORT? In 2001, CDC presented the groundbreaking re- sults of a new study describing the exposure of theAmerican public to environmental pollutants. This CDC study was the first in a series of annual reports that is the most comprehensive assess- ment of its kind. It tries to identify exposures to specific toxic chemicals in the U.S. population. It estimates the degree of exposure by measuring amounts of those pollutants in the body. These data are gathered through biological monitoring, or biomonitoring, in which samples of urine or blood are collected from members of the popu- lation and analyzed for specific chemicals. (Refer to the following section for more information about biomonitoring.) The National Exposure Report presents bio- monitoring data for a representative cross-section of the American population, made up of several thousand people from across the country. These data are part of a larger study called the National The full report with chemical profiles is available at www.envirohealthaction.org/bearingtheburden.
  • 6. 4 www.envirohealthaction.org/bearingtheburden Bearing the Burden Health and Nutrition Examination Survey, or NHANES, in which volunteers are examined for a broad range of health measures. Among other tests, NHANES participants provide blood and urine that are tested for specific environmental chemicals. Study participants are selected from 15 different geographic regions of the U.S. and represent different segments of the population, including African Americans, Mexican Ameri- cans,adolescents,pregnant women,children,and the elderly. The first National Exposure Report included biomonitoring data for 27 different environmen- tal chemicals,including heavy metals,certain pes- ticides, and phthalates (chemicals used to make plastics, cosmetics, and other products). In 2001, CDC committed to adding new chemicals in sub- sequent reports. In the 2003 National Exposure Report, CDC presents findings for more than 100 different environmental chemicals. This latest re- port includes many new chemicals and chemical types not addressed in the first report, including persistent organochlorine pesticides, herbicides, fungicides, pest repellents, carbamate pesticides, polychlorinated biphenyls (PCBs), dioxins, and a class of chemicals called polycyclic aromatic hy- drocarbons(PAHs).Thesechemicalsaredescribed in more detail in the full online report. Improve- ments in measuring chemicals should allow more to be monitored in coming years. Inthe2003report,CDChascombinedthedata from the 1999 NHANES (presented in the 2001 National Exposure Report) with data from the current survey to develop a baseline of environ- mental chemical exposures. This baseline will be compared with results of future analyses and will beusefulinidentifyinggeneraltrendsinexposures acrossthepopulationandwithinsubgroupsof the population.Thesebaselinedatawillalsohelpphy- sicians interpret the results of biological sampling on patients and will help health scientists priori- tize needs for research on exposure and health ef- fects of chemicals of concern. WHAT DOES THE NATIONAL EXPOSURE REPORT TELL US? The overall purpose of the National Exposure Re- port is to provide a “snapshot” of the types and amounts of environmental chemical exposures in theU.S.population.Physicians,scientists,andpub- lic health officials can use the information to pre- ventdiseasesthatmightbecausedbyenvironmen- tal contaminants. While the study tries to repre- sent a large part of the U.S. population, a particu- lar person’s exposure to environmental chemicals may be very different from the sample in the re- port.Individualexposuresmaybehigherorlower, dependingonfactorssuchasdiet,age,occupation, chemical use, and many other variables. In general,the amount of a chemical measured in blood or urine reflects the amount of a person’s exposure to that chemical.However,some chemi- cals are rapidly broken down by the body and can be eliminated within hours or days following ex- posure. This makes them more difficult to detect throughrandomtesting.Ontheotherhand,more persistent chemicals (e.g., certain pesticides, di- oxins, and PCBs) are not readily broken down and can be stored in fatty tissues and organs for many years.In such cases,levels in blood or urine may reflect only a fraction of the total amount of stored chemical in the body (called body burden). It is therefore important that the chemical levels presented in the National Exposure Report be interpreted with care and that they be used as broad indicators of exposure rather than exact measurements.
  • 7. www.envirohealthaction.org/bearingtheburden 5 Health Implications of Environmental Pollutants in Our Bodies The National Exposure Report does not mea- suretheriskof diseasefromenvironmentalchemi- cal exposures, nor does it relate chemical levels in the body to disease. Information on body burden of pollutants provided by CDC’s biomonitoring study is only one piece of the puzzle. There are more than 70,000 industrial chemicals registered for use in the U.S today. For the vast majority of these chemicals, scientists know little or nothing about releases to the environment, levels of hu- man exposure,or long-term effects on health.For manyenvironmentalpollutants,scientistsareonly beginning to understand how levels of pollutants in the body relate to health effects and disease.We have an incomplete picture of the various chemi- cal contaminants in our food, water, and air. We need to learn much more about how people are exposed and how chemicals are broken down or stored by the human body.These are critical miss- ing links in our understanding, and they are the focusof intensivestudybyhealthresearchers.This information is important for all Americans, but particularly for those individuals who may be es- pecially vulnerable to the effects of certain chemi- cals. These include infants, young children, and pregnant women. WHAT IS BIOMONITORING? Biological monitoring, or biomonitoring, is de- fined as the measurement of toxic substances in the body.Scientists can analyze samples of urine, serum, saliva, blood, breast milk, and other tis- sues (such as body fat and teeth) to measure the levels of various chemicals in the body. Biomonitoring can show whether and how much an individual or population has been exposed to a chemical.When combined with efforts to track disease patterns, this information can be helpful in determining whether chemical exposures are causing illness and may aid in deciding what type of medical treatment is needed. Biomonitoring is also a valuable tool in disease prevention. Early detection of chemical exposure, followed by prompt and appropriate intervention to limit or stop the exposure, can help prevent illness from occurring. While biomonitoring is not a new concept,the CDC’s effort is the most intensive and compre- hensive so far, aimed at measuring the types and amounts of environmental pollutants and other toxic chemicals Americans have in their bodies. Together with other environmental databases (re- porting, for example, chemical releases to air or water), this effort is an important step in under- standing our exposure to toxic chemicals in the environment and finding ways to reduce and ul- timately eliminate our exposure to environmen- tal pollutants. WHAT CHEMICALS DID CDC MEASURE THIS YEAR? In its 2001 report,CDC presented biomonitoring data that demonstrated exposure to 27 environ- mental chemicals—heavy metals, breakdown products (metabolites) of organophosphate pes- ticides, phthalates (chemicals used to make plas- tics, cosmetics, and other products), and one in- door air pollutant (cotinine, which represents exposure to tobacco smoke). The2003NationalExposureReportincludesthe samechemicalsreportedbyCDCin2001andmany new ones. The following table summarizes the en- vironmental chemicals addressed in the current Report and the most common ways humans are exposed.An asterisk (*) indicates that the chemical class was also included in the first Report.
  • 8. 6 www.envirohealthaction.org/bearingtheburden Bearing the Burden Chemical class Examples Primary Exposure Routes HEAVY METALS * Chromium, lead, Foods with pesticide or fertilizer residue; mercury contaminated air/water/soil, especially in vicinity of hazardous waste or other industrial sites PHTHALATES * DEHP, DEP, DBP Cosmetics; contaminated food; some PVC plastic products; contaminated air/water/soil, especially in vicinity of hazardous waste or other industrial sites PESTICIDES Non-persistent Pesticides • Organophosphate Diazinon, malathion Foods (especially fruits and vegetables) pesticides * contaminated with pesticide residues; lawns and gardens; contaminated indoor dust • Carbamate pesticides Aldicarb (Temik), Residues on crop foods; lawns and gardens; carbaryl (Sevin), flea/tick repellents propoxur (Baygon) Persistent Pesticides • Organochlorine DDT, aldrin, dieldrin, Fatty foods (primarily fish, meat, dairy, eggs) pesticides chlordane PEST REPELLENTS DEET Repellent products applied directly to skin FUNGICIDES Ortho-phenylphenol Residential insecticides and disinfectants HERBICIDES 2,4-D, alachlor, Foods; contaminated water; residential plant atrazine growth regulators DIOXINS 2,3,7,8-TCDD, many Fatty foods (primarily fish, meat, dairy, eggs); other forms contaminated soil/sediment, especially in vicinity of incinerators, hazardous waste, or other industrial sites POLYCHLORINATED Many different forms Fatty foods (primarily fish, meat, eggs, dairy, BIPHENYLS (PCBs) processed food); contaminated soil/sediment, especially in vicinity of hazardous waste or other industrial sites POLYCYCLIC AROMATIC Benzo[a]pyrene, Tobacco or wood smoke; fossil fuel HYDROCARBONS (PAHs) 1-benzo[a]anthracene combustion products; grilled foods; contaminated ambient air; dairy foods COTININE * — Tobacco products or second-hand tobacco smoke
  • 9. www.envirohealthaction.org/bearingtheburden 7 Health Implications of Environmental Pollutants in Our Bodies WHAT HAPPENS TO POLLUTANTS IN THE BODY? The effect of chemicals on the body depends on a number of different factors. Chemical-specific properties, the amount, duration, and timing of exposure, the route of exposure (e.g., eating/ drinking, breathing, skin contact), and an individual’s genetic makeup affect how a chemi- cal behaves in the body and its toxic effects. A discussion of these complex factors and their in- teractions is beyond the scope of this document. Rather,this section focuses on some key concepts to help understand biomonitoring data. Biomonitoring studies are designed to recog- nize the unique behavior of each chemical in the body.This knowledge is used to determine which body tissues and fluids should be sampled and which specific chemical markers should be mea- sured. Some chemicals, such as heavy metals and certain pesticides, are toxic without breaking down in the body and are excreted practically unchanged. These chemicals can be measured directly in the blood or urine. Other chemicals, such as organophosphate and carbamate pesti- cides, are partially or totally broken down in the body, forming new chemicals called metabolites. These metabolites can then be measured in blood or urine. Some metabolites are unique, in that they are formed from one specific parent com- pound. Measurements of such metabolites are highly useful in confirming exposure to specific chemical pollutants.Other metabolites,however, can have multiple sources and are less specific indicators of exposure. For example, dimethyl- phosphate is a metabolite of more than a dozen different organophosphate pesticides. Without more specific chemical markers, biomonitoring studies can only broadly show possible exposure to a chemical or class of chemicals. Finally, certain chemicals or metabolites may be stored in various tissues of the body, such as fat,organs,blood,hair,bones,orteeth.Theamount of stored chemical in the body is referred to as the bodyburden.Itisimportanttoknowwhichchemi- calsarestoredinthebodybecausetheyareasource for continued exposure with potentially serious healthconsequences.Somechemicals,whenstored in the body for prolonged periods, can increase the potential for disease to occur. For more information, refer to the National Insti- tutes of Health, National Library of Medicine (NLM) web site on Toxicology and Environmental Health, found at http://sis.nlm.nih.gov/Tox/ ToxMain.html. WHAT IS THE DIFFERENCE BETWEEN “ACUTE” AND “CHRONIC” EXPOSURES AND EFFECTS? The terms acute and chronic are often used to de- scribe types of chemical exposure or the health effects resulting from such exposure. These are termsthatyouwillseeusedfrequentlyintheonline chemicalsummaries.Theyapplytothetimingand not the severity of the exposure.An acute exposure refers to an exposure that occurs over a short pe- riod or in a single dose. An acute effect is one that occurs within a short time (often hours or days) following a brief exposure. Acute exposures (and effects) are more typical in the workplace or from accidental poisonings. The term chronic exposure refers to a chemical exposure that occurs repeat- edly over a long period (months or years) and of- ten at low concentrations. Chronic, low-level ex- posures are much more common in everyday life than acute, high-level exposures. Most people en- counter low levels of many different chemicals
  • 10. 8 www.envirohealthaction.org/bearingtheburden Bearing the Burden throughtheireverydayactivities.Thisexposurecan continue undetected for days, months, or years. Exposures to pollutants are most often chronic exposures with long-term health effects.A chronic effect is one that shows up a long time after expo- sure or that results from a long-term exposure. It is important to recognize that acute exposures can have both acute and chronic health effects. When a chemical is first studied,research tends to focus on acute health effects.Chronic health ef- fects (cancer, for instance) studies are expensive and time-consuming and are therefore available for only a fraction of the toxic chemicals in use. For these reasons, our understanding of the chronic health effects of many chemicals is lim- ited.Inrecentyears,however,researchhasfocused more on long-term, chronic effects of chemical exposures. As a result of this research, scientists are discovering effects on the developing fetus,ef- fects on brain and nervous system development, and disruption of the human hormonal and re- productive systems. For example, animal studies have shownthatcertainpesticidescandamagethe brain,producingasyndromesimilartoParkinson’s disease. These findings support growing evidence that pesticide exposure, including in-home expo- sure, might contribute to the development of Parkinson’s disease in humans. Because most people in the U.S. are mostly ex- posed to low levels of chemicals over long periods of time, the data in the National Exposure Report reflect such exposures, rather than acute or high- levelexposures.Similarly,thesummariespresented in this report online focus on chronic health ef- fects and effects of low-level exposure, where we know or have good reason to suspect them.While the health effects information presented here is drawn from the most authoritative sources avail- able, including Environmental Protection Agency (EPA) and CDC, new information on chemical health effects is becoming available almost daily. Consequently,the profiles maynotincludeallthat iscurrentlyknownaboutthesechemicalsandmay, in fact, understate potential health consequences of long-term exposures. REGULATORY PROGRAMS FOR PROTECTION OF PUBLIC HEALTH FROM CHEMICAL EXPOSURES The federal government has a variety of regula- toryprogramsintendedtoreduceexposuretotoxic substances to workers and the general public. For some chemicals, there are enforceable maximum levels of pollutants in air, industrial emissions, drinking water,food products,and workplace set- tings. However, as CDC’s National Exposure Re- port shows, the public is exposed to a variety of pollutants in spite of these regulations. Biomonitoringdatafromthisandfutureyearsmay ultimatelyprovehelpfulinidentifyingcriticalgaps and shortcomings in the laws and regulations de- signed to prevent or minimize such exposures. The chemical profiles at www.envirohealth action.org/bearingtheburdenidentifyspecificfed- eral standards, where they exist. It is important to note that allowable levels of chemicals in the envi- ronment and the workplace are not comparable to the levels that CDC has measured in human bloodandurinesamples.So-called“legally”safelev- els of human exposure have not been determined for many chemicals. But for some chemicals, there may be no safe level of exposure, especially for vul- nerable people like pregnant women and young children. The regulations and standards presented here are listed for the purpose of showing where efforts to limit human exposures exist.
  • 11. www.envirohealthaction.org/bearingtheburden 9 Health Implications of Environmental Pollutants in Our Bodies Drinking Water Standards The Safe Drinking Water Act (SDWA) authorizes EPA to establish allowable levels of contaminants in public drinking water supplies. The National Primary Drinking Water Standards are intended to protect consumers from adverse health effects of contaminants in public water systems.Enforce- able standards, called Maximum Contaminant Levels (MCLs), have been established for a num- berof contaminants,includingmanyof thechemi- calsaddressedinCDC’sNationalExposureReport. Public water systems are required to meet these standards through drinking water treatment or othertechniques.Inspiteof EPA’sregulations,test- ing has shown that allowable levels of many con- taminants are frequently exceeded in some public drinkingwatersupplies.Furthermore,privatewells are not tested for contaminants,and EPA does not regulate the quality of water from such wells. MCLs,expressedasmilligramsof contaminantper liter of water, or mg/L, are cited in the chemical profiles, if applicable. For more information about EPA drinking water programs, refer to http://www.epa.gov/safewater/. A list of current federal drinking water standards and health advisories is available online at http:// www.epa.gov/ost/drinking/standards/dwstandards.pdf. Air Quality Standards The Clean Air Act is the main law for protecting Americans from air pollutants. Under this law, EPA requires the reduction of emissions of vari- ous types of air pollutants. For example, EPA is required to establish NationalAmbient Air Qual- ity Standards for six of the most common air pollutants in the U.S. (so-called “criteria air pol- lutants”), one of which is lead, a chemical in- cluded in CDC’s National Exposure Report.1 In addition, EPA has taken steps to protect the pub- lic from other air pollutants that are known or suspected to cause cancer and other serious health effects, including many of the pollutants ad- dressed by CDC. Ways these pollutants are re- duced include controls on industrial sources and vehicle emissions and reductions of levels in in- door air. Despite these programs, however, air pollution continues to pose a serious health threat in many communities,with pollutants frequently exceeding the national standards. More information on criteria air pollutants is avail- ableathttp://www.epa.gov/air/urbanair/6poll.html. Additional details on EPA’s air toxics program can be found in the publication “Taking Toxics Out of the Air,” which is available online at http:// www.epa.gov/oar/oaqps/takingtoxics/.Alistof EPA- designated hazardous air pollutants is available onlineathttp://www.epa.gov/ttn/atw/188polls.html. Chemical Residues in Food The EPA,Food and Drug Administration (FDA), and U.S. Department of Agriculture (USDA) share responsibility for protecting consumers from exposure to pesticides and other contami- nants in the food supply. EPA sets limits on the amount of pesticides that can be applied to food crops and the levels of pesticide residues that can remain on food when it is sold. The Food Qual- ity Protection Act of 1996 requires the EPA to review pesticide food residue limits (known as “tolerances”) and consider combined exposures 1. The six pollutants are ozone, sulphur dioxide, oxides of nitrogen, lead, particulate matter, and carbon monoxide.
  • 12. 10 www.envirohealthaction.org/bearingtheburden Bearing the Burden for those pesticides that have a common mecha- nism of toxicity,a process that has been extremely slow. EPA is currently reviewing organophos- phate pesticides, such as those addressed by CDC’s National Exposure Report.FDA is respon- sible for enforcing pesticide tolerances on all foods except meat,poultry,and certain egg prod- ucts, which are regulated by the USDA. FDA also sets enforcement guidelines called“action levels” for pesticides that are no longer allowed (such as DDT) as well as non-pesticide contaminants (e.g., cadmium, lead, mercury, and PCBs) found in food.FDA conducts annual surveys to determine residue levels of pesticides,metals,radionuclides, PCBs, and volatile organic compounds in the food supply. If it finds a chemical residue higher than allowed during these surveys, the FDA has the authority to remove contaminated foods from the market; however, severe limitations of the surveys leave most foods in the U.S.untested and restrict the FDA’s actions. Overall,despite three federal agencies oversee- ing food safety, harmful chemical contaminants in food are not well monitored or regulated. In- deed, a recent FDA study found residues of 12 persistent organic pollutants (POPs) in the aver- age American diet. These results highlighted two regulatory flaws. First, health limits are estab- lished for a single chemical and not for the total amount of similar chemicals found in the entire diet.Second,FDA’s action levels for chemicals are significantly higher than the health-based levels regulated by the EPA. For more information on FDA’s Total Diet Study, refer to http://www.cfsan.fda.gov/~comm/tds- toc.html. EPA publications provide more informa- tion on regulation of pesticides in food: “Pesticides and Food: How the Government Regulates Pesti- cides”is available online at www.epa.gov/pesticides/ food/govt.htm, and residue tolerances for specific foods and pesticides can be found by searching EPA’s database at http://www.epa.gov/pesticides/food/ viewtols.htm. Worker Protection Standards Health-based standards to protect workers from chemical, physical, and biological agents in the workplace are developed by the federal Occupa- tional Health and SafetyAdministration (OSHA). OSHA has established maximum acceptable lev- els (called Permissible Exposure Levels, or PELs) for a large number of airborne chemicals found in the workplace.The intention of PELs is to show how much workers can be exposed to a substance without harmful effects averaged over a normal 8-hour workday or a 40-hour week (called a time- weighted average, or TWA). However, there is no consensus among the occupational health com- munity that PELs protect workers. The OSHA standards (known as PEL-TWAs) for workplace exposures are identified in the“Regulations”sec- tion of each chemical profile. The National Institute for Occupational Safety and Health (NIOSH) and the American Confer- ence of Governmental and Industrial Hygienists (ACGIH), a non-government organization, have also recommended exposure limits for many chemicals to help protect worker health.However, these limits are not enforceable standards and are not cited in the chemical profiles. The full list of OSHA standards is available online at http://www.osha.gov/SLTC/respiratory_advisor/ advisor_genius_nrdl/z_tables.html (29CFR 1910.1000, Table Z-1 and Z-2). For more informa- tion, on NIOSH recommendations refer to the
  • 13. www.envirohealthaction.org/bearingtheburden 11 Health Implications of Environmental Pollutants in Our Bodies NIOSH Pocket Guide to Chemical Hazards http:// www.cdc.gov/niosh/npg/npg.htmlandACGIH2002 ThresholdLimitValuesforChemicalSubstancesand PhysicalAgents,BiologicalExposureIndicesathttp:/ /www.acgih.org/home.htm. THE STOCKHOLM CONVENTION ON PERSISTENT ORGANIC POLLUTANTS Many of the chemicals addressed in CDC’s Na- tional Exposure Report belong to a group of sub- stancescalledpersistentorganicpollutants,orPOPs. These chemicals are of particular public health concern because of their high toxicity, extreme persistence in the environment, ability to travel long distances through air and water, and strong tendency to accumulate in fatty tissues of animals and humans. They bioconcenrate up the food chain and can reach very high levels in the body tissues of fish, predatory birds, and mammals, in- cludinghumans.Biomonitoringstudieshavecon- firmed that almost everyone carries traces of these persistent chemicals in their bodies. In the U.S., the manufacture and use of some POPsarealreadyrestrictedorprohibited.However, thisisnotthecaseinmanyothercountries.Because POPs can move readily through the environment, their continued use anywhere becomes a concern fortheglobalcommunity.TheStockholmConven- tion is an international treaty targeting the elimi- nation of these toxic chemicals, beginning with 12 of the worst POPs. These are: nine pesticides (ald- rin, chlordane, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene,mirex,andtoxaphene);thein- dustrial chemicals hexachlorobenzene and PCBs; andthetoxicchemicalbyproducts,polychlorinated dioxins and furans.The Convention will also allow countriestoacttogethertorestrictadditionalPOPs in the future. The Stockholm Convention was formally adopted in May 2001 and has been signed by the U.S. and more than 150 countries. Governments mustnowratifytheagreement,andwhen50coun- tries have done so, the treaty will enter into force. FormoreinformationabouttheStockholmConven- tion,refer to the web sites for the International POPs Elimination Network (IPEN) at http://ipen.ecn.cz/, the United Nations Environment Programme (UNEP)POPswebsiteathttp://www.chem.unep.ch/ pops/, and PSR’s EnviroHealthAction web site at http://www.envirohealthaction.org. THE PUBLIC HEALTH IMPLICATIONS OF THE CDC REPORT: HEALTH TRACKING The data in CDC’s National Exposure Report show thatAmericans are exposed to a broad spec- trum of potentially hazardous chemicals. These exposures have occurred because of both current and past contacts with chemical contaminants in the food we eat, the air we breathe, and the water we drink. CDC’s exposure data are significant to our health, since they represent actual pollutants in human body tissues and fluids. While these data are a concern, what they mean regarding human disease is uncertain. We do not have enough scientific knowledge. PSR believes the CDC biomonitoring data present a significant public health opportunity. Biomonitoring is an important part of under- standing the connection between specific chemi- cal exposure and chronic disease. EPA currently tracks environmental hazards through its Toxic Release Inventory, which monitors chemical re- leases to the environment. But no comprehen- sive system exists to collect chronic disease infor-
  • 14. 12 www.envirohealthaction.org/bearingtheburden Bearing the Burden mation. PSR recommends the creation of a na- tionwide environmental health tracking network to monitor and analyze data on chronic condi- tions and their relationship to the external envi- ronment. An effective tracking network should include local, state, and federal public health agencies that work together to follow the inci- dence and prevalence of certain chronic diseases. When combined with data from biomonitoring and hazard tracking, the disease data will give health practitioners and environmental regula- tors the ability to identify disease clusters and make informed decisions when formulating policy that affects health. More research is needed to understand the health effects of the chemicals tested by the CDC. Enough is known, though, that we should reduce exposurethroughpollutionpreventionefforts,vig- orousenforcementof workplaceandenvironmen- talstandards,andpeople’spersonaleffortstoavoid contact with hazardous substances. The chemical information in the online report can be used by individuals and groups as a resource for pollution prevention programs and lifestyle choices. THE FULL REPORT WITH CHEMICAL PROFILES IS AVAILABLE AT: www.envirohealthaction.org/bearingtheburden.
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  • 16. This is a publication of Physicians for Social Responsibility. For reprint information or for additional copies, please contact: Physicians for Social Responsibility, 1875 Connecticut Ave., NW, Suite 1012, Washington, DC 20009; Phone: 202-667-4260; Fax: 202-667-4201; Homepage: http://www.psr.org, www.envirohealthaction.org PHYSICIANS FOR SOCIAL RESPONSIBILITY Robert K. Musil, PhD, MPH, Executive Director and CEO Susan West Marmagas, MPH, Director, Environmentand Health Program Karen L. Perry, MPA, Deputy Director, Environment and Health Program Michelle Chuk, MPH, Public Health Program Director, Environment and Health Program Laura Rasar King, MPH, CHES, Outreach Director, Environment and Health Program PRIMARY CONTRIBUTORS Carolyn Poppell, ScM Robin Clarke, Intern, Environment and Health Program MEDICAL AND SCIENTIFIC ADVISORS (affiliations are listed for identification purposes only and do not imply organizational endorsement of this publica- tion or its content) John M. Balbus, MD, MPH, Staff Physician, Washington Hospital Center and Director, Environmental Health Program, Environmental Defense Barry L. Johnson, PhD, FCR, U.S. Assistant Surgeon General (Retired) Philip J. Landrigan, MD, Chair, Department of Community and Preventive Medicine, Mount Sinai School of Medicine Ted Schettler, MD, MPH, Co-chair, Human Health and Environment Project, Greater Boston Physicians for Social Responsibility PHYSICIANS FOR SOCIAL RESPONSIBILITY 1875 Connecticut Avenue, NW, Suite 1012 Washington, DC 20009 US Affiliate of International Physicians for the Prevention of Nuclear War Copyright 2003 by Physicians for Social Responsibility. All rights reserved. No part of this publication may be reproduced without permission of Physicians for Social Responsibility, the U.S. Affiliate of International Physicians for the Prevention of Nuclear War.