Generating pure water is one of the major concerns in the pharmaceutical industry. For the manufacturing of parenteral products, water for injection has to be used as it is free of pyrogens and other forms of microbial contamination. Reverse osmosis and filtration are widely used as a purified water system for removing pyrogens and producing water for injection. Ultra-filtration is another method used to reduce the toxins in the drugs.

1. Significance of Purified Water System in a Pharma
Industry
TSA Water Systems

2. Generating pure water is one of the major concerns in the pharmaceutical
industry. For the manufacturing of parenteral products, water for injection has to
be used as it is free of pyrogens and other forms of microbial contamination.
Reverse osmosis and filtration are widely used as a purified water system for
removing pyrogens and producing water for injection. Ultra-filtration is another
method used to reduce the toxins in the drugs.
Water is used for multiple purposes in the pharmaceutical industry such as
cleaning purposes, dilution of strong liquids, as a stabilizer and sometimes also
used to transport some drugs and products. Water is also used as a solvent for
processing, as a raw material for the formulation of products and the cleaning of
pharmaceutical devices. The quality of water used depends on the type of
application it is used for. For example, cleaning requires portable water, but for
the formulation of products, water has to comply with strict purity regulations.
There are mainly two types of water that are processed in a purified water
system. One is demineralized water and the other is purified water.

3. Demineralization is the process in which salts and certain minerals are removed
from the feed water. Raw water contains various impurities and salts that may
damage the machinery. This impure water containing minerals is called hard
water. The hard water is very much harmful to the equipment and machinery as it
can corrode the internal parts of the machine and can lead to rusting of the metal
parts. To normalize the hard water, the ion exchange method is generally used. In
ion-exchange anion exchange resin removes the minerals containing positive
charge and cation exchange resin removes the minerals with a negative charge.
On the other hand, purified water is generated from the ultraviolet method,
reverse osmosis and multi-column distillation plant. They aim to reduce the
number of microbes present in the water and also prevent recontamination of the
water from pathogens.
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