The document describes a dissolvable microneedle patch that can deliver cosmetic and pharmaceutical ingredients through the skin in a painless and bloodless manner. It discusses the benefits of microneedle patches for anti-wrinkle and other dermatological uses. Clinical trials showed that an anti-wrinkle microneedle patch significantly improved wrinkles and skin elasticity over an 8 week period without adverse effects.

1. Dissolving Microneedle Patch
Anti-Wrinkle Science

2. Dissolving microneedle
Nobel Smart Patch
► Painless
► Bloodless
► Dose & Time – Easy Controlled System
Dissolution after microneedle penetrates dermis
Dissolving form after penetrating human skin / SEM Image
▪ Next generation transdermal drug delivery system (microneedle TDS system)
+ Microneedle Fabrication + Bio degradable polymers + Drug Delivery System
▪ World's first patented dissolvable cosmetic dermal patch directly delivers
cosmetic components to the epidermis of the skin without causing skin
damage or pain (US Pat #6,945,952 #7,182,747, #7,211,062)
▪ The revolutionary dissolvable micro needle can be used for various
dermatologic purposes in beauty and therapeutic care.

3. Benefits of microneedle
MICRONEEDLE ARRAY
Effortless and painless
Precise control of
penetration depth
Direct and
controlled delivery
Ability to manipulate
The drug formulation;
suspension, powder,..
Patient self-administration
Fast Dissolving

4. A
B
C
D
PharmaceuticalsBeauty Care
Beauty Clinic Immuno-cell therapy
▪ Anti -wrinkle
▪ Whitening & Anti-pigmentation
(dark circles, age spots, freckles)
▪ Anti-hair loss
 Skin trouble
▪ Anti-acne
▪ Alopecia area treatment
▪ Botox patch
▪ Flu vaccine
▪ Arthritis cure
Langerhans cells in dermis
▪ Insulin patch
▪ Growth hormone patch
▪ PTH patch (osteoporosis)
▪ EPO
▪ Fentanyl patch (pain-killer)
Application of microneedle

5. Anti-wrinkle microneedle patch
Backing film
Protect Cover
Microneedle disk (Green part)
Patch structure & Materials
250 μm
▪ Product: KEY-265 De-Aging Patch (Wrinkle Improver)
► Patching duration: Approximately 10~15 minutes (rapid dissolution after skin penetration)
▪ Structure of microneedle
► Length of microneedle(3types) : 250㎛ / 200 ㎛ / 150 ㎛ → Selective penetration of stratum corneum and epidermis
► Microneedle materials
① for mechanical structure and dissolution : Na-CMC, Sucrose, Trehalose, Collagen, etc.
② Wrinkle-improving Ingredients : Adenosine, vitamin C, EGF, biopeptide (CTP, AHP, PPP)
▪ Patch type : Circular type, Eye line type, Square type (Disk weight : 0.04g~0.05g)
Benefits
► The dissolvable microneedle, It’s revolutionary transdermal delivery systems to
replace fearful injection and needles with a patch that can be painlessly and simply
applied by a patient. ( Botox injection ► Botox Patch )
► This world’s first patented microneedle path directly delivers cosmetic ingredients to the
inner skin, which is enhancing the absorption and penetration of active ingredients
dramatically than normal skin care.
( penetration & absorption : KEY265 ► 100% >>> normal skin care ► 0.3%)
► Excellent safety
No adverse skin reaction, No skin irritation, Germ free, Not re-use(safe disposal )
Smart Patch

6. Anti-wrinkle Line
Product Line Sets
Anti-wrinkle patch (15/20pairs/pack) Ample (10ml x 3ea) Serum (40ml) Cream (40ml) Eye cream (15ml)
▪ Anti-wrinkle line (4kinds) : Ample (10ml), Serum (40ml), Cream (40ml), Eye cream (15ml) ► Certified for wrinkle improvement by KFDA
+ Brand : ‘xxxxx’( ref. Ample ► ‘xxxxx Renutrive ample’ )
▪ Key ingredients
① Ample ► freeze drying powder (Growth factor complex) + Solution (Peptide complex + Adenosine + Others)
- Growth factor complex powder : EGF, bFGF, KGF-2, IGF-1, SOD1
② Serum – Eye cream – Cream
- Growth factor complex : EGF-bFGF-KGF-IGF-SOD - Peptide complex : CTP – AHP – PPP – KVARP
▪ Safety : No chemical preservative (paraben), No chemical fragrance, No chemical surfactant ► Dr. Brand concept
▪ Benefits : Certified for Wrinkle Improvement by KFDA , Firming, Cellular repair, More Elasticity, Even skin tone, Moisturizing
Hi-Tech
(DR. & Global brand)
Hi-Touch
Natural+Eco-phil
Transdermal Delivery
System Design & Brand

7. Clinic test for anti-wrinkle improvement
Anti-Wrinkle Improvement
0 Week 4 Week 8 Week
Digital
image
3D
image
Deral
image
0
2
4
6
8
10
12
0 week 4 week 8 week
%
Anti-wrinkle improvement [Ra]
* Improvement = 20.5%
▣ Clinic test on human skin ; Evaluation of skin wrinkle, elasticity and dermal density of KEY265 (dis-solvable microneedle patch)
► Clinic center : Dermapro / Skin Research Center Test Period April 25 ~ July 21 Numbers : 20 women (aver aged 44.7 yrs)
[ Statistical analysis of Ra wrinkle parameter on crow’s foot ]
Fine line wrinkles(Ra) were significantly decreased at 4
and 8weeks compare to before treatment.
* Decrement value represents improvement of skin wrinkle
Parameter Week N Mean(μm) SD SEM Decrement(%)
Ra
0W 20 15.18 2.31 0.52 -
4W 20 13.73 2.12 0.47 9.55 ▼
8W 20 13.09 2.12 0.47 13.77 ▼

8. 8
Human clinic
#06 #08 #09 #10 #12
0W
4W
8W
8.5% 14.6% 21.8% 20.5% 26.9%
Improve
-ment
Clinic test for anti-wrinkle improvement

9. Manufacturing Process
Mixing Dispensing
Cosmetic rawmaterial
Biopolymers
De-air
Aging
Molding Drying Patching Packaging
Inspection of raw materials
Confidential
Silicon
molding
▪ Press molding
Dispenser ▪ Molding (centrifuge)
▪ Drying chamber
▪ Coating
▪ Laminating
▪ Cutting
▪ Assembly
▪ packagingHomogenizer Mixer
+ API
+ Biopolymer
+ Additives

10. Thanks
For question or inquiry of sample and trial order
E-mail: kwon.hb@gmail.com / andy.mylee@gmail.com
Phone: +82-505-288-0011
WhatsApp: +82-10-8557-3292 / +82-10-5474-9905