The Advanced Glycolic Acid/Antioxidant Line.

1. VIVITÉ®
The Advanced Glycolic Acid/Antioxidant Line

2. The Role of Physician-Dispensed Topical Aesthetics
 Topical aesthetics can be used to help improve the appearance of
skin’s condition alone or in conjunction with other procedures
 Topical aesthetics can complement and help promote skin
treatments
– eg, moisturizers can be beneficial with treatments that leave the skin dry
 Patients pleased with their results from facial injectables may wish
to complement them through a physician-dispensed skin care
regimen
 Aesthetic improvements may translate into greater interest in more
advanced procedures
– ie, dermal fillers, facial injectables, and/or lasers and peels
Behl P. Professional Skin Care 2006, Vol I: United States. Little Falls, NJ: Kline & Company, Inc.

3. VIVITÉ® Skin Care Products Are Appropriate for
All Patients
 VIVITÉ® is an advanced glycolic and natural antioxidant
system that helps improve the appearance of mild to
moderate photodamaged skin in as few as 3 weeks1,2
– Advanced skin care system designed with GLX Technology™*
– Helps improve the appearance of mild to moderate
photodamaged skin
– For all skin care patients
– For patients who are dissatisfied with their current skin care
system
– Appropriate for all skin types (universal anti-aging system)
*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.
1. Data on file. Allergan, Inc.; 2. Downie JB. Cosmet Dermatol. 2008;21:168-175.

4. VIVITÉ® Line of Skin Care Products
 VIVITÉ® Core System
– VIVITÉ® Exfoliating Facial Cleanser
– VIVITÉ® Daily Antioxidant Facial Serum
– VIVITÉ® Revitalizing Eye Treatment
– VIVITÉ® Night Renewal Facial Cream
 VIVITÉ® Daily Facial Cleanser
 VIVITÉ® Daily Facial Moisturizer SPF 30
 VIVITÉ® Vibrance Therapy
 VIVITÉ® Replenish Hydrating Cleanser
 VIVITÉ® Replenish Hydrating Cream
 VIVITÉ® GLX I Facial Peel Gel
 VIVITÉ® Defining Lip Plumper
 VIVITÉ® Daily Firming Lotion
 VIVITÉ® Back Bar Products
– VIVITÉ® Exfoliating Facial Cleanser
– VIVITÉ® Replenish Hydrating Cream
Data on file. Allergan, Inc.

5. VIVITÉ® Skin Care Products Are Developed With
Proprietary GLX Technology™
 VIVITÉ® Skin Care Products are developed with proprietary
GLX Technology™
– This formula matrix is designed to help act as a vehicle for the deep
penetration of glycolic acid bound to natural antioxidants
– Helps enhance the skin’s natural production of hyaluronic acid and
epidermal growth factor (EGF); stimulates collagen; and protects
epidermal cells
– Helps allow high amounts of glycolic acid to be released over an
extended period for maximum efficacy with minimum irritation
– Helps raise product pH closer to that of normal skin to reduce irritation
– Helps retain a reservoir of alpha hydroxy acid (AHA) for secondary
exfoliation
 Contains botanicals and innovative ingredients: chamomile, aloe,
wild mango butter, green tea, pomegranate, licorice root, caffeine,
olive leaf extract, algae extract peptides, superoxide dismutase,
exfoliating microbeads, and interference pearls
*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.
Data on file. Allergan, Inc.

6. In a 3-Week Clinical Trial, VIVITÉ® Core Systems
Helped Improve Photodamaged Skin
After 3 Weeks’ Use
100
90 N=24
80
70 65
From Baseline (%)
60
Improvement
54
50
40 36
30 22
20
10
0
Fine Lines and Moisture* Smoothness Dryness
Wrinkles
*Mean value of suborbital (38%) and cheek areas (34%).
Downie JB. Cosmet Dermatol. 2008;21:168-175.

7. VIVITÉ® Vibrance Is a Natural Hydroquinone-Free
Agent for Skin Brightening
 A natural hydroquinone-free agent for skin brightening and
even skin tone
– Anti-aging GLX Technology™ (glycolic acid, ammonium glycolate, and
olive leaf extract)
– Skin brightening/antioxidant complex:
 Tyrosinase inhibition – methyl dihydroxybenzoate
 Increase cellular activity – retinol and glycolic
 Oxidative inhibition – soy isoflavones, glycyrrhiza glabra (licorice)
root extract, morus nigra (mulberry) fruit extract, grape (vitis vinifera)
extract, feoniculum vulgare (fennel) seed extract, lycopene, olea
europaea (olive) leaf extract, superoxide dismutase, tocopherol, and
magnesium ascorbyl phosphate
– Skin redness reducing actives: allantoin glycyrrhetinic, acid bisabolol,
and camellia oleifera (Japanese green tea) leaf extract
– Humectants: glycerin and butylene glycol
– Emollients: dimethicone and squalane
*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.
Data on file. Allergan, Inc.

8. VIVITÉ® Vibrance 8-Week Clinical Trial Design
 An 8-week, randomized, double-blind, split-face study of
VIVITÉ® Vibrance used on one side of the face (also
randomized) and a 4% HQ bleaching gel used on the
other side of the face
– Expert grader evaluations were made at baseline and at 4 and
8 weeks
– Twenty-one women aged 20 to 75 years with moderate
pigmentation of the face participated in the trial; 18 (86%)
completed the study
 No patients dropped out of the clinical trial due to
irritation
McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

9. VIVITÉ® Vibrance Helped Improve the Appearance of Fine
Lines/Wrinkles, Skin Roughness, and Hyperpigmentation
After 8 Weeks of Treatment
Expert Evaluator
100
90 N=21
Percent Improvement
80
70%
70 66% 63%
61%
60
50
40
30 27% 27%
20
10
0
Fine Lines/Wrinkles Roughness Hyperpigmentation
Natural-based Bleaching Cream 4% HQ Gel
McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

10. VIVITÉ® Vibrance Helped Improve Hyperpigmentation
After 8 Weeks of Treatment
Processed UV RBX Brown (hyperpigmentation)
Baseline Week 8 Baseline Week 8
Photos are completely untouched. Individual results may vary.
McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

11. Summary
 Topical aesthetics can be used to help improve the appearance of skin’s
condition alone or in conjunction with other procedures
 VIVITÉ® is an advanced glycolic and natural antioxidant system that helps
improve the appearance of mild to moderate photodamaged skin in as few
as 3 weeks1,2
– VIVITÉ® Skin Care Products are developed with proprietary
GLX Technology™* which is designed to help act as a vehicle for
the deep penetration of glycolic acid bound to natural antioxidants
 VIVITÉ® Vibrance is a natural hydroquinone-free agent for
skin brightening and even skin tone
– VIVITÉ® Vibrance helped improve the appearance of fine lines and wrinkles, skin
roughness, and hyperpigmentation after 8 weeks of treatment3
*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.
1. Data on file. Allergan, Inc.; 2. Downie JB. Cosmet Dermatol. 2008;21:168-175; 3. McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

12. Allergan Supports the Pillars of Successful Practice
Patient loyalty and practice growth
Industry- Familiarity,
Patient Practice
leading trust, and
satisfaction building
products confidence
APC72LJ10
©2010 Allergan, Inc. ® and ™ marks owned by Allergan, Inc.